TDMS Study 97013-96 Pathology Tables
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 1
Natural Death 1
Survivors
Terminal Sacrifice 9 9 10 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 1 (10%) 1 (10%)
Infiltration Cellular 1 (10%)
Infiltration Cellular, Lymphocyte 2 (20%) 4 (40%) 4 (40%) 2 (20%)
Inflammation 8 (80%) 7 (70%) 8 (80%) 7 (70%)
Necrosis 3 (30%) 2 (20%) 1 (10%) 1 (10%)
Hepatocyte, Fatty Change 2 (20%) 2 (20%) 3 (30%) 6 (60%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 9 (90%) 10 (100%) 8 (80%)
Serosa, Inflammation 1 (10%)
Mesentery (1) (1)
Inflammation 1 (100%)
Fat, Necrosis 1 (100%)
Salivary Glands (1)
Atrophy 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%) 2 (20%)
Inflammation 1 (10%)
Epithelium, Hyperplasia 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Subcapsular, Hyperplasia 9 (90%) 10 (100%) 10 (100%) 8 (80%)
Pituitary Gland (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 (10%)
Hyperplasia 1 (10%)
Pars Intermedia, Hyperplasia 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (9) (10) (10)
Angiectasis 1 (11%)
Atrophy 1 (10%)
Cyst 3 (30%) 2 (22%) 1 (10%) 2 (20%)
Uterus (10) (10) (10) (10)
Inflammation 2 (20%) 1 (10%) 2 (20%) 1 (10%)
Endometrium, Hyperplasia, Cystic 8 (80%) 8 (80%) 8 (80%) 6 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (50%)
Lymph Node, Mandibular (10) (10) (10) (9)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%)
Hyperplasia, Atypical 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 2 (20%) 1 (10%) 2 (20%)
Thymus (10) (9) (10) (10)
Atrophy 2 (20%) 1 (11%) 2 (20%)
Cyst 7 (70%) 6 (67%) 8 (80%) 8 (80%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1)
Ulcer 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Accumulation, Hyaline Droplet 1 (10%)
Casts Protein 8 (80%) 1 (10%) 5 (50%) 3 (30%)
Infiltration Cellular, Lymphocyte 1 (10%) 4 (40%) 1 (10%)
Mineralization 1 (10%)
Nephropathy 3 (30%) 1 (10%) 8 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 3
Natural Death 1
Survivors
Terminal Sacrifice 9 10 9 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Muscularis, Degeneration 1 (100%)
Liver (10) (10) (10) (10)
Atypia Cellular 1 (10%)
Clear Cell Focus 1 (10%)
Hematopoietic Cell Proliferation 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%) 2 (20%)
Inflammation 9 (90%) 5 (50%) 7 (70%) 6 (60%)
Necrosis 2 (20%)
Hepatocyte, Fatty Change 8 (80%) 4 (40%) 3 (30%) 4 (40%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 10 (100%) 9 (90%)
Salivary Glands (2)
Inflammation 2 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Inflammation 1 (10%)
Epithelium, Hyperplasia 1 (10%) 1 (10%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hyperplasia 1 (10%)
Hypertrophy 2 (20%) 4 (40%) 2 (20%)
Subcapsular, Hyperplasia 2 (20%) 2 (20%) 3 (30%) 2 (20%)
Islets, Pancreatic (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (100%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (10) (9) (10) (10)
Cyst 4 (40%) 3 (33%) 3 (30%) 3 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (10) (10) (10)
Mineralization 1 (10%)
Germinal Epithelium, Degeneration 2 (20%) 2 (20%) 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Atrophy 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 (10%) 2 (20%)
Spleen (10) (10) (10) (10)
Atrophy 3 (30%)
Hematopoietic Cell Proliferation 1 (10%)
Thymus (10) (10) (10) (10)
Atrophy 1 (10%) 3 (30%)
Cyst 8 (80%) 7 (70%) 3 (30%) 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 15:25:34
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Inflammation 1 (100%)
Lacrimal Gland (1) (1)
Inflammation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 (10%)
Hydronephrosis 1 (10%) 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%)
Mineralization 1 (10%) 1 (10%)
Nephropathy 5 (50%) 4 (40%) 9 (90%) 8 (80%)
Renal Tubule, Degeneration 6 (60%) 10 (100%)
Renal Tubule, Dilatation 1 (10%) 3 (30%) 2 (20%)
Renal Tubule, Necrosis 1 (10%)
Renal Tubule, Vacuolization Cytoplasmic 10 (100%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
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