https://ntp.niehs.nih.gov/go/11681

TDMS Study 97013-96 Pathology Tables

NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03
Route: DOSED WATER                                                                                                Time: 15:28:19
                                                           FINAL/MICE
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  75-27-4
       Lock Date:  07/19/01
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1                         1                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            8                                     
  Animals Examined Microscopically                    10           10           10           10                                     
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 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Polyp Stromal                                    2 (20%)                                                                      
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                                                             Page   2                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node                                         (1)          (2)                                                              
      Carcinoma, Metastatic, Skin                      1 (100%)                                                                     
      Mediastinal, Osteosarcoma, Metastatic, Bone                   1 (50%)                                                         
      Renal, Carcinoma, Metastatic, Skin               1 (100%)                                                                     
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 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                                                             (1)                                    
      Carcinoma                                                                               1 (100%)                              
   Skin                                               (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                                            (2)                                                              
      Vertebra, Osteosarcoma                                        2 (100%)                                                        
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)                                   
      Carcinoma, Metastatic, Skin                      1 (10%)                                                                      
      Osteosarcoma, Metastatic, Bone                                1 (10%)                                                         
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (10%)                                                                      
   Pleura                                                          (1)                                                              
      Osteosarcoma, Metastatic, Bone                                1 (100%)                                                        
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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                                                             Page   3                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   4                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)             3           2                       1                                       
     Total Primary Neoplasms                            3           2                       1                                       
   Total Animals with Benign Neoplasms                  2                                                                           
     Total Benign Neoplasms                             2                                                                           
   Total Animals with Malignant Neoplasms               1           2                       1                                       
     Total Malignant Neoplasms                          1           2                       1                                       
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          4           3                                                               
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                                      3                                     
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9            7                                     
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Small, Duodenum                          (10)         (10)         (10)         (10)                                   
   Intestine Small, Jejunum                           (10)         (10)         (9)          (10)                                   
   Intestine Small, Ileum                             (10)         (10)         (10)         (10)                                   
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatocellular Adenoma                                        1 (10%)      1 (10%)                                            
   Mesentery                                                                    (1)                                                 
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (10)         (10)         (10)         (10)                                   
   Prostate                                                                                  (1)                                    
      Sarcoma                                                                                 1 (100%)                              
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                                                             Page   6                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
   Spleen                                             (10)         (10)         (10)         (10)                                   
   Thymus                                             (10)         (10)         (10)         (10)                                   
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                                              (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar/Bronchiolar Carcinoma                                                          1 (10%)                               
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)                                   
                                                             Page   7                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Lymphoma Malignant                               1 (10%)                   2 (20%)                                            
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)             1           1           4           2                                       
     Total Primary Neoplasms                            1           1           4           2                                       
   Total Animals with Benign Neoplasms                              1           1                                                   
     Total Benign Neoplasms                                         1           1                                                   
   Total Animals with Malignant Neoplasms               1                       3           2                                       
     Total Malignant Neoplasms                          1                       3           2                                       
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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