TDMS Study 97013-04 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 05/18/05
EXPERIMENT: 97013 TEST: 04 TIME: 09:03:49
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: DOSED WATER NTP: C97013E
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 05/18/05
EXPERIMENT: 97013 TEST: 04 TIME: 9:09:52
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DOSED WATER NTP: 97013E
CONT: NO1-ES-65406 CAS: 75-27-4
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
==================================================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 3.7 22.8 2.2 23.0 0.59 17 1.4 22.9 0.38 21 1.2 22.5 0.32 37
2 3.7 24.2 2.9 23.7 0.78 21 2.5 21.8 0.68 41 2.2 20.1 0.59 76
3 3.6 25.6 3.1 25.0 0.86 22 2.5 24.2 0.69 36 2.5 22.0 0.69 81
4 3.4 26.7 2.9 26.2 0.85 20 2.5 25.2 0.74 35 2.3 24.1 0.68 68
5 3.6 27.9 3.0 26.9 0.83 20 2.7 26.4 0.75 36 2.4 24.8 0.67 69
6 3.3 28.3 2.9 28.1 0.88 18 2.7 26.9 0.82 35 2.4 24.8 0.73 69
7 3.7 30.2 3.1 28.5 0.84 19 2.8 27.4 0.76 35 2.7 25.2 0.73 74
8 4.0 31.1 3.3 30.3 0.83 19 2.9 28.3 0.73 36 2.6 26.0 0.65 71
9 3.7 33.0 3.1 32.1 0.84 17 2.8 29.7 0.76 33 2.6 27.2 0.70 67
10 4.0 34.7 3.2 33.5 0.80 17 3.0 30.7 0.75 34 2.8 27.9 0.70 70
11 3.7 36.1 3.2 35.2 0.86 16 2.9 32.1 0.78 32 3.1 27.9 0.84 77
12 3.7 37.0 3.1 36.3 0.84 15 2.7 33.1 0.73 28 2.9 29.0 0.78 70
13 3.9 38.4 3.2 37.3 0.82 15 2.9 33.3 0.74 30 2.9 29.6 0.74 68
14 4.0 38.9 3.2 38.3 0.80 15 2.9 34.2 0.73 30 2.8 30.1 0.70 65
15 4.0 39.8 3.2 38.9 0.80 14 2.9 35.2 0.73 29 2.8 30.8 0.70 64
16 3.8 40.8 3.2 39.2 0.84 14 2.7 36.1 0.71 27 2.8 31.2 0.74 62
17 4.1 42.0 3.3 40.6 0.80 14 3.0 37.1 0.73 28 2.8 32.1 0.68 62
18 4.0 42.9 3.4 40.8 0.85 15 3.1 37.5 0.78 29 2.9 33.0 0.73 62
19 3.9 43.4 3.1 42.0 0.79 13 3.0 37.6 0.77 28 2.9 33.3 0.74 61
20 3.9 43.8 3.2 43.0 0.82 13 3.1 38.8 0.79 28 2.8 33.9 0.72 58
21 4.1 45.1 3.2 43.7 0.78 13 3.1 39.4 0.76 28 3.0 34.7 0.73 61
22 4.0 45.9 3.4 44.2 0.85 13 3.6 39.6 0.90 31 3.0 34.8 0.75 61
23 4.0 46.4 3.2 45.0 0.80 12 3.0 41.0 0.75 26 3.0 35.1 0.75 61
24 4.0 47.1 2.9 45.6 0.73 11 2.9 41.1 0.73 25 2.8 36.9 0.70 53
25 3.9 47.4 3.3 45.2 0.85 13 3.0 41.5 0.77 26 3.1 36.0 0.79 61
26 4.1 47.8 3.3 46.3 0.80 12 3.1 42.7 0.76 26 3.1 36.5 0.76 59
1 TO 13 WEEKS
----------------
MEAN 3.7 30.5 3.0 29.7 0.82 18 2.6 27.9 0.72 33 2.5 25.5 0.68 69
SD(D) 0.2 0.3 0.07 2 0.4 0.11 5 0.5 0.12 11
CV(E) 5.1 8.7 8.8 12.5 15.7 15.0 14.5 18.7 18.1 15.3
14 TO 52 WEEKS
----------------
MEAN 4.0 43.9 3.2 42.5 0.81 13 3.0 38.6 0.76 28 2.9 33.7 0.73 61
SD(D) 0.1 0.1 0.03 1 0.2 0.05 2 0.1 0.03 3
CV(E) 2.3 4.1 4.3 7.8 6.3 6.4 6.8 4.6 4.1 4.9
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
==================================================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 4.1 18.9 2.3 18.9 0.56 22 1.6 18.8 0.39 30 1.4 18.6 0.34 54
2 4.1 19.6 2.9 19.6 0.71 26 2.8 19.3 0.68 51 2.7 19.1 0.66 98
3 4.3 20.8 3.6 20.2 0.84 31 3.2 20.0 0.74 56 3.1 20.0 0.72 107
4 3.8 21.8 3.5 21.4 0.92 28 3.6 21.4 0.95 59 3.3 21.1 0.87 110
5 4.1 22.1 3.5 21.9 0.85 28 3.7 21.9 0.90 59 3.8 22.0 0.93 120
6 4.1 22.0 3.6 21.9 0.88 29 3.7 22.4 0.90 58 3.7 22.3 0.90 117
7 4.2 22.3 4.0 22.1 0.95 31 4.0 21.8 0.95 65 3.9 21.9 0.93 126
8 4.1 23.3 3.8 22.5 0.93 29 3.9 23.2 0.95 59 3.6 22.7 0.88 112
9 4.2 23.6 3.7 23.0 0.88 28 3.7 23.5 0.88 55 3.9 22.4 0.93 121
10 4.1 24.6 3.8 23.7 0.93 28 3.8 24.3 0.93 55 3.8 24.1 0.93 112
11 4.1 24.7 3.8 24.4 0.93 27 3.8 24.6 0.93 54 3.6 24.1 0.88 105
12 4.2 25.3 3.8 24.5 0.90 27 3.9 25.2 0.93 54 3.7 24.6 0.88 104
13 3.9 26.5 3.7 25.2 0.95 26 3.7 25.8 0.95 50 3.6 24.9 0.92 101
14 4.1 27.1 3.8 26.0 0.93 25 3.8 27.0 0.93 50 3.5 25.9 0.85 96
15 4.1 27.9 3.8 26.4 0.93 25 3.8 27.3 0.93 48 3.7 26.3 0.90 98
16 4.2 29.0 4.0 26.4 0.95 27 3.9 27.8 0.93 50 3.7 26.9 0.88 97
17 4.3 28.7 4.0 26.8 0.93 26 4.1 28.3 0.95 51 3.9 28.4 0.91 96
18 4.4 29.1 4.2 27.6 0.95 27 4.1 28.7 0.93 50 4.0 27.6 0.91 100
19 4.3 29.8 4.0 28.1 0.93 25 4.0 29.2 0.93 48 3.9 27.5 0.91 99
20 4.3 30.6 4.1 29.1 0.95 25 3.9 29.4 0.91 46 4.0 28.3 0.93 98
21 4.3 31.5 3.9 29.7 0.91 23 4.0 30.4 0.93 46 3.9 29.2 0.91 95
22 4.4 32.7 4.2 30.8 0.95 24 4.3 30.9 0.98 49 4.0 30.0 0.91 92
23 4.3 34.0 3.9 32.2 0.91 21 3.8 32.9 0.88 41 4.0 30.4 0.93 92
24 4.1 35.3 3.5 32.1 0.85 19 3.4 33.2 0.83 36 3.7 30.8 0.90 83
25 4.3 35.6 4.3 32.1 1.00 23 4.1 32.6 0.95 44 3.9 31.3 0.91 88
26 4.3 36.4 4.1 33.2 0.95 21 3.9 34.0 0.91 40 3.9 31.7 0.91 85
1 TO 13 WEEKS
----------------
MEAN 4.1 22.7 3.5 22.2 0.86 28 3.5 22.5 0.85 54 3.4 22.1 0.83 107
SD(D) 0.1 0.4 0.11 3 0.7 0.16 8 0.7 0.17 18
CV(E) 3.1 12.4 12.9 9.1 18.6 19.0 15.1 20.1 20.4 16.6
14 TO 52 WEEKS
----------------
MEAN 4.3 31.4 4.0 29.3 0.93 24 3.9 30.1 0.92 46 3.8 28.8 0.90 94
SD(D) 0.1 0.2 0.03 2 0.2 0.04 5 0.1 0.02 5
CV(E) 2.2 5.2 3.7 9.5 5.5 3.9 10.1 3.8 2.2 5.7
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
=========================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 22.8 15 23.0 15 22.9 15 22.5 15
1 3.7 1035 22.8 15 2.2 951 23.0 15 1.4 963 22.9 15 1.2 942 22.5 15
2 3.7 2426 24.2 15 2.9 2324 23.7 15 2.5 2288 21.8 15 2.2 2500 20.1 15
3 3.6 2329 25.6 15 3.1 2509 25.0 15 2.5 2379 24.2 15 2.5 2428 22.0 15
4 3.4 2371 26.7 15 2.9 2467 26.2 15 2.5 2495 25.2 15 2.3 2175 24.1 15
5 3.6 2359 27.9 15 3.0 2324 26.9 15 2.7 2418 26.4 15 2.4 1950 24.8 15
6 3.3 2395 28.3 15 2.9 2118 28.1 15 2.7 2257 26.9 15 2.4 2421 24.8 15
7 3.7 2389 30.2 15 3.1 2360 28.5 15 2.8 2222 27.4 15 2.7 2320 25.2 15
8 4.0 2379 31.1 15 3.3 2393 30.3 15 2.9 2371 28.3 15 2.6 2475 26.0 15
9 3.7 2523 33.0 15 3.1 2550 32.1 15 2.8 2277 29.7 15 2.6 2454 27.2 15
10 4.0 2342 34.7 15 3.2 2393 33.5 15 3.0 2058 30.7 15 2.8 2267 27.9 15
11 3.7 2331 36.1 15 3.2 2434 35.2 15 2.9 2277 32.1 15 3.1 2061 27.9 15
12 3.7 2448 37.0 15 3.1 2439 36.3 15 2.7 2303 33.1 15 2.9 2375 29.0 15
13 3.9 2516 38.4 15 3.2 2493 37.3 15 2.9 2227 33.3 15 2.9 2295 29.6 15
14 4.0 2421 38.9 15 3.2 2447 38.3 15 2.9 2419 34.2 15 2.8 2185 30.1 15
15 4.0 2530 39.8 15 3.2 2294 38.9 15 2.9 2430 35.2 15 2.8 2465 30.8 15
16 3.8 2555 40.8 15 3.2 2380 39.2 15 2.7 2374 36.1 15 2.8 2442 31.2 15
17 4.1 2550 42.0 15 3.3 2362 40.6 15 3.0 2324 37.1 15 2.8 2565 32.1 15
18 4.0 2377 42.9 15 3.4 2158 40.8 15 3.1 2119 37.5 15 2.9 2357 33.0 15
19 3.9 2530 43.4 15 3.1 2580 42.0 15 3.0 2210 37.6 15 2.9 2402 33.3 15
20 3.9 2424 43.8 15 3.2 2530 43.0 15 3.1 2488 38.8 15 2.8 2530 33.9 15
21 4.1 2442 45.1 15 3.2 2444 43.7 15 3.1 2184 39.4 15 3.0 2346 34.7 15
22 4.0 2490 45.9 15 3.4 2324 44.2 15 3.6 1984 39.6 15 3.0 2320 34.8 15
23 4.0 2510 46.4 15 3.2 2520 45.0 15 3.0 2523 41.0 15 3.0 2326 35.1 15
24 4.0 2290 47.1 15 2.9 2418 45.6 15 2.9 2112 41.1 15 2.8 2094 36.9 15
25 3.9 2511 47.4 15 3.3 2333 45.2 15 3.0 2366 41.5 15 3.1 2341 36.0 15
26 4.1 2385 47.8 15 3.3 2418 46.3 15 3.1 2485 42.7 15 3.1 2396 36.5 15
27 3.9 1447 3.1 1470 2.8 1372 3.1 1372
MEAN BODY WGT FOR WEEKS
1 TO 13 30.5 29.7 27.9 25.5
14 TO 52 43.9 42.5 38.6 33.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
=========================================================================================================
0 MG/L 175 MG/L 350 MG/L 700 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 18.9 15 18.9 15 18.8 15 18.6 15
1 4.1 925 18.9 15 2.3 867 18.9 15 1.6 1011 18.8 15 1.4 822 18.6 15
2 4.1 2354 19.6 15 2.9 2309 19.6 15 2.8 2135 19.3 15 2.7 2306 19.1 15
3 4.3 2426 20.8 15 3.6 2336 20.2 15 3.2 2436 20.0 15 3.1 2423 20.0 15
4 3.8 2565 21.8 15 3.5 2565 21.4 15 3.6 2387 21.4 15 3.3 2440 21.1 15
5 4.1 2350 22.1 15 3.5 2443 21.9 15 3.7 2309 21.9 15 3.8 2442 22.0 15
6 4.1 2440 22.0 15 3.6 2425 21.9 15 3.7 2066 22.4 14 3.7 2371 22.3 15
7 4.2 2355 22.3 15 4.0 2044 22.1 15 4.0 2014 21.8 14 3.9 1713 21.9 15
8 4.1 2386 23.3 15 3.8 2302 22.5 15 3.9 2212 23.2 14 3.6 2398 22.7 15
9 4.2 2515 23.6 15 3.7 2396 23.0 15 3.7 2272 23.5 14 3.9 2349 22.4 15
10 4.1 2375 24.6 15 3.8 2145 23.7 15 3.8 1933 24.3 14 3.8 2182 24.1 15
11 4.1 2217 24.7 15 3.8 2331 24.4 15 3.8 2069 24.6 14 3.6 1960 24.1 15
12 4.2 2452 25.3 15 3.8 2255 24.5 15 3.9 2183 25.2 14 3.7 2348 24.6 15
13 3.9 2297 26.5 15 3.7 2520 25.2 15 3.7 2255 25.8 14 3.6 2421 24.9 15
14 4.1 2520 27.1 15 3.8 2417 26.0 15 3.8 2352 27.0 14 3.5 2447 25.9 15
15 4.1 2357 27.9 15 3.8 2421 26.4 15 3.8 2288 27.3 14 3.7 2427 26.3 15
16 4.2 2366 29.0 15 4.0 2285 26.4 15 3.9 2288 27.8 14 3.7 2302 26.9 15
17 4.3 2350 28.7 15 4.0 2403 26.8 15 4.1 2287 28.3 14 3.9 2523 28.4 15
18 4.4 2351 29.1 15 4.2 2303 27.6 15 4.1 2117 28.7 14 4.0 2260 27.6 15
19 4.3 2580 29.8 15 4.0 2480 28.1 15 4.0 2008 29.2 14 3.9 2408 27.5 15
20 4.3 2452 30.6 15 4.1 2362 29.1 15 3.9 2174 29.4 14 4.0 2320 28.3 15
21 4.3 2368 31.5 15 3.9 2311 29.7 15 4.0 2330 30.4 14 3.9 2356 29.2 15
22 4.4 2470 32.7 15 4.2 2150 30.8 15 4.3 2127 30.9 14 4.0 2126 30.0 15
23 4.3 2520 34.0 15 3.9 2328 32.2 15 3.8 2110 32.9 14 4.0 2527 30.4 15
24 4.1 2330 35.3 15 3.5 2166 32.1 15 3.4 1716 33.2 14 3.7 2301 30.8 15
25 4.3 2201 35.6 15 4.3 2334 32.1 15 4.1 2095 32.6 14 3.9 2435 31.3 15
26 4.3 2423 36.4 15 4.1 2182 33.2 15 3.9 2254 34.0 14 3.9 2373 31.7 15
27 4.0 1470 3.7 1325 3.6 1349 3.8 1470
MEAN BODY WGT FOR WEEKS
1 TO 13 22.7 22.2 22.5 22.1
14 TO 52 31.4 29.3 30.1 28.8
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.