TDMS Study 97013-04 Pathology Tables
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/L
Include 004 175 MG/L
Include 006 350 MG/L
Include 008 700 MG/L
Include 001 0 MG/L
Include 003 175 MG/L
Include 005 350 MG/L
Include 007 700 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 15 15 14 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 1 (7%) 4 (27%) 4 (27%) 1 (7%)
Inflammation 13 (87%) 13 (87%) 12 (80%) 12 (80%)
Necrosis 2 (13%) 2 (13%) 1 (7%)
Hepatocyte, Fatty Change 1 (7%) 1 (7%) 10 (67%)
Hepatocyte, Vacuolization Cytoplasmic 11 (73%) 10 (67%) 7 (47%) 11 (73%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 13 (87%) 12 (80%) 14 (93%) 14 (93%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (15) (15) (15) (15)
Cyst 1 (7%) 2 (13%)
Thyroid Gland (15) (15) (15) (14)
Cyst 1 (7%)
C-Cell, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Angiectasis 1 (7%)
Cyst 2 (13%) 1 (7%) 2 (13%) 5 (33%)
Uterus (15) (15) (15) (15)
Inflammation 1 (7%) 1 (7%) 1 (7%)
Endometrium, Hyperplasia, Cystic 8 (53%) 7 (47%) 9 (60%) 8 (53%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
Lymphoid Follicle, Atrophy 1 (7%)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%)
Cyst 6 (40%) 11 (73%) 9 (60%) 11 (73%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Congestion 1 (7%)
Infiltration Cellular, Lymphocyte 1 (7%) 1 (7%) 1 (7%)
Inflammation 1 (7%)
Thrombosis 1 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 (20%) 10 (67%) 7 (47%) 6 (40%)
Nephropathy 2 (13%) 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation 12 (80%) 14 (93%) 13 (87%) 13 (87%)
Hepatocyte, Fatty Change 4 (27%) 5 (33%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 15 (100%) 15 (100%) 13 (87%) 11 (73%)
Mesentery (1)
Fat, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 2 (13%)
Hypertrophy 2 (13%) 2 (13%)
Subcapsular, Hyperplasia 2 (13%) 3 (20%) 1 (7%) 3 (20%)
Pituitary Gland (15) (15) (15) (15)
Cyst 3 (20%) 1 (7%) 1 (7%) 4 (27%)
Thyroid Gland (15) (14) (15) (15)
Cyst 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (15) (15) (15) (15)
Granuloma Sperm 1 (7%) 1 (7%)
Inflammation 1 (7%)
Testes (15) (15) (15) (15)
Mineralization 1 (7%) 1 (7%) 2 (13%)
Germinal Epithelium, Degeneration 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (15) (15) (15) (15)
Cyst 9 (60%) 12 (80%) 6 (40%) 9 (60%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Fibrosis 1 (7%)
Infiltration Cellular, Histiocyte 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:29:19
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 (7%) 5 (33%) 4 (27%) 7 (47%)
Cyst 1 (7%)
Mineralization 1 (7%)
Nephropathy 7 (47%) 3 (20%) 11 (73%) 13 (87%)
Cortex, Crystals 1 (7%)
Renal Tubule, Degeneration 9 (60%) 12 (80%)
Renal Tubule, Dilatation 5 (33%) 4 (27%) 6 (40%)
Renal Tubule, Vacuolization Cytoplasmic 14 (93%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
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