TDMS Study 97013-04 Pathology Tables
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/L
Include 004 175 MG/L
Include 006 350 MG/L
Include 008 700 MG/L
Include 001 0 MG/L
Include 003 175 MG/L
Include 005 350 MG/L
Include 007 700 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 15 15 14 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 1 [1.0] 4 [1.0] 4 [1.3] 1 [2.0]
Inflammation 13 [1.0] 13 [1.0] 12 [1.0] 12 [1.0]
Necrosis 2 [1.0] 2 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 1 [1.0] 1 [1.0] 10 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 11 [1.0] 10 [1.0] 7 [1.0] 11 [1.2]
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 13 [1.0] 12 [1.0] 14 [1.0] 14 [1.0]
Parathyroid Gland (1)
Cyst 1 [2.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 1 [1.0] 2 [1.0]
Thyroid Gland (15) (15) (15) (14)
Cyst 1 [1.0]
C-Cell, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Angiectasis 1 [2.0]
Cyst 2 [1.0] 1 [1.0] 2 [1.0] 5 [1.0]
Uterus (15) (15) (15) (15)
Inflammation 1 [1.0] 1 [1.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 8 [1.4] 7 [1.3] 9 [1.2] 8 [1.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
Lymphoid Follicle, Atrophy 1 [2.0]
Lymphoid Follicle, Hyperplasia 1 [2.0]
Thymus (15) (15) (15) (15)
Atrophy 1 [2.0]
Cyst 6 [1.0] 11 [1.0] 9 [1.1] 11 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Congestion 1 [2.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [1.0] 1 [1.0]
Inflammation 1 [1.0]
Thrombosis 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 [1.0] 10 [1.0] 7 [1.0] 6 [1.0]
Nephropathy 2 [1.0] 2 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation 12 [1.0] 14 [1.0] 13 [1.0] 13 [1.0]
Hepatocyte, Fatty Change 4 [1.0] 5 [1.2] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 15 [3.1] 15 [2.7] 13 [1.9] 11 [1.2]
Mesentery (1)
Fat, Necrosis 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 2 [1.5]
Hypertrophy 2 [1.0] 2 [1.0]
Subcapsular, Hyperplasia 2 [1.0] 3 [1.0] 1 [1.0] 3 [1.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 3 [1.0] 1 [1.0] 1 [1.0] 4 [1.0]
Thyroid Gland (15) (14) (15) (15)
Cyst 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (15) (15) (15) (15)
Granuloma Sperm 1 [2.0] 1 [2.0]
Inflammation 1 [2.0]
Testes (15) (15) (15) (15)
Mineralization 1 [1.0] 1 [1.0] 2 [1.0]
Germinal Epithelium, Degeneration 2 [1.5] 1 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (15) (15) (15) (15)
Cyst 9 [1.0] 12 [1.2] 6 [1.0] 9 [1.1]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Fibrosis 1 [1.0]
Infiltration Cellular, Histiocyte 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:34:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 [1.0] 5 [1.0] 4 [1.0] 7 [1.3]
Cyst 1 [2.0]
Mineralization 1 [1.0]
Nephropathy 7 [1.0] 3 [1.0] 11 [1.5] 13 [2.1]
Cortex, Crystals 1 [1.0]
Renal Tubule, Degeneration 9 [1.0] 12 [1.0]
Renal Tubule, Dilatation 5 [1.0] 4 [1.0] 6 [1.2]
Renal Tubule, Vacuolization Cytoplasmic 14 [1.4] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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