TDMS Study 97013-05 Pathology Tables
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/L
Include 004 175 MG/L
Include 006 350 MG/L
Include 008 700 MG/L
Include 001 0 MG/L
Include 003 175 MG/L
Include 005 350 MG/L
Include 007 700 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 4 2 1 1
Moribund Sacrifice 1 3 1
Survivors
Terminal Sacrifice 10 13 11 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 (100%)
Liver (15) (15) (15) (15)
Basophilic Focus 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 3 (20%) 1 (7%)
Inflammation 11 (73%) 11 (73%) 13 (87%) 14 (93%)
Mitotic Alteration 1 (7%)
Necrosis 2 (13%) 1 (7%)
Hepatocyte, Fatty Change 4 (27%) 8 (53%) 10 (67%)
Hepatocyte, Hypertrophy 1 (7%) 2 (13%) 8 (53%) 12 (80%)
Hepatocyte, Vacuolization Cytoplasmic 2 (13%) 5 (33%) 4 (27%) 8 (53%)
Salivary Glands (1) (1)
Inflammation 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Hypertrophy 1 (7%)
Subcapsular, Hyperplasia 8 (53%) 8 (53%) 7 (47%) 10 (67%)
Pituitary Gland (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 1 (7%)
Thyroid Gland (15) (14) (15) (15)
Cyst 1 (7%) 1 (7%) 2 (13%) 1 (7%)
Inflammation 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%)
Oviduct (1)
Inflammation, Suppurative 1 (100%)
Uterus (15) (15) (15) (15)
Hydrometra 1 (7%)
Inflammation, Suppurative 1 (7%)
Endometrium, Hyperplasia, Cystic 9 (60%) 8 (53%) 9 (60%) 8 (53%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia 1 (7%) 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%) 1 (7%)
Infiltration Cellular, Polymorphonuclear 1 (7%) 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%)
Hematopoietic Cell Proliferation 2 (13%) 3 (20%) 3 (20%) 1 (7%)
Lymphoid Follicle, Atrophy 1 (7%) 1 (7%)
Red Pulp, Atrophy 1 (7%)
Thymus (14) (15) (15) (14)
Atrophy 2 (14%) 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (6) (3)
Epidermis, Hyperplasia, Focal 1 (17%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Infiltration Cellular, Histiocyte 1 (7%)
Inflammation 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 (7%) 3 (20%) 2 (13%)
Cyst 2 (13%) 3 (20%) 1 (7%) 2 (13%)
Inflammation 1 (7%)
Nephropathy 1 (7%) 1 (7%) 4 (27%)
Renal Tubule, Hypertrophy 1 (7%) 2 (13%) 5 (33%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 3 3 1
Survivors
Terminal Sacrifice 13 12 12 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 (100%)
Intestine Small, Duodenum (15) (15) (15) (15)
Erosion 1 (7%)
Liver (15) (15) (15) (15)
Cyst 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Inflammation 7 (47%) 6 (40%) 7 (47%) 5 (33%)
Necrosis 3 (20%) 1 (7%) 3 (20%) 3 (20%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 3 (20%) 3 (20%)
Salivary Glands (1) (2) (1)
Inflammation 1 (100%)
Inflammation, Chronic Active 1 (50%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 1 (7%)
Hypertrophy 6 (40%) 7 (47%) 7 (47%) 9 (60%)
Subcapsular, Hyperplasia 1 (7%) 1 (7%) 1 (7%)
Pituitary Gland (15) (15) (15) (15)
Cyst 1 (7%)
Inflammation, Suppurative 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Inflammation 1 (7%)
Preputial Gland (3) (1)
Inflammation 2 (67%) 1 (100%)
Duct, Ectasia 3 (100%) 1 (100%)
Testes (15) (15) (15) (15)
Hypoplasia 1 (7%)
Germinal Epithelium, Degeneration 3 (20%) 2 (13%) 3 (20%) 3 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (14) (13)
Hyperplasia 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%) 1 (7%)
Inflammation 1 (7%)
Necrosis 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 4 (27%) 2 (13%)
Lymphoid Follicle, Atrophy 1 (7%) 1 (7%)
Thymus (15) (14) (15) (15)
Atrophy 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (2) (2) (1)
Epidermis, Hyperplasia, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:34:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 1 (7%) 1 (7%) 1 (7%)
Thrombosis 1 (7%) 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Retina, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 (7%) 2 (13%) 1 (7%) 1 (7%)
Cyst 2 (13%) 3 (20%)
Mineralization 2 (13%)
Nephropathy 4 (27%) 3 (20%) 4 (27%) 11 (73%)
Renal Tubule, Degeneration 4 (27%) 4 (27%) 9 (60%)
Renal Tubule, Dilatation 4 (27%) 11 (73%) 14 (93%) 15 (100%)
Renal Tubule, Hypertrophy 1 (7%) 3 (20%) 6 (40%) 11 (73%)
Renal Tubule, Necrosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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