TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 FINAL #1 RATS Facility: Battelle Northwest Chemical CAS #: 1321-74-0 Lock Date: 04/16/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7| DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3| | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + A + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Spleen | X | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Mesentery | + + + + + + +| |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7| DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3| | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7| DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3| | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Adenoma | | Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Carcinoma, Metastatic,| | Zymbal's Gland | X | Deep Cervical, Leukemia Mononuclear | | Pancreatic, Histiocytic Sarcoma, | | Metastatic, Spleen | X | Pancreatic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M + M M M + M M M M M M M + M M + M M M M M +| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M + + M M + + M + + M M M M + + + M + + + M + M| Carcinoma, Metastatic, Zymbal's Gland| X | Leukemia Mononuclear | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + M + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7| DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3| | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | Leukemia Mononuclear | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7| DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3| | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Spleen | | 1 | Leukemia Mononuclear | X X X X X X | 10 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 15 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X X | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X | 37 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Polyp Stromal | X X X X X| 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + | 6 | Deep Cervical, Carcinoma, Metastatic,| | | Zymbal's Gland | | 1 | Deep Cervical, Leukemia Mononuclear | X | 1 | Pancreatic, Histiocytic Sarcoma, | | | Metastatic, Spleen | | 1 | Pancreatic, Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M M M M M + M M M + M M M M M M + M M M M| 8 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M + M M M M M M + M M M M M M M M M M M| 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + + + + + + + + M M + M + + M + + M M| 32 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | Leukemia Mononuclear | X X X X X | 6 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + + + M + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X X | 3 | Fibroadenoma | X X X X X X X| 14 | Fibroadenoma, Multiple | X X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| | | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 2 | Leukemia Mononuclear | X X X X X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3| | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X | Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + +| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3| | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Sarcoma Stromal | | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3| | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Schwannoma Malignant | | Cervix, Sarcoma Stromal | | |__________________________________________________________________________| Vagina | + | Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + | Deep Cervical, Leukemia Mononuclear | | Pancreatic, Carcinoma, Metastatic, | | Mammary Gland | | Pancreatic, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M M M + M M M M M M M M M M M + + M M M + M| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M + M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M + + M + M M + + + + M + + + + + + + + + + M M| Carcinoma, Metastatic, Mammary Gland | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + M + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3| | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Adenoma | | Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + I | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Leukemia Mononuclear | X X X X X X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3| | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + I + + + + + + A + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | | 2 | Leukemia Mononuclear | X X X X X X X X X | 17 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + +| 20 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 34 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X| 5 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X X X | 6 | Sarcoma Stromal | X | 1 | Schwannoma Malignant | X | 1 | Cervix, Sarcoma Stromal | X | 1 | |__________________________________________________________________________|____________| Vagina | + | 2 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 10 | Deep Cervical, Leukemia Mononuclear | X | 1 | Pancreatic, Carcinoma, Metastatic, | | | Mammary Gland | X | 1 | Pancreatic, Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M M M + M M M + M M M M + M + M M M M + M| 9 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + M + + + + M + + M + + + + + + + + + + + +| 37 | Carcinoma, Metastatic, Mammary Gland | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 18 | |__________________________________________________________________________|____________| Thymus | + M M M + + M + + M + + M + + + + + + + + + + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | X X | 4 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X X X | 14 | Fibroadenoma, Multiple | X X | 8 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | X | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vertebra, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Leukemia Mononuclear | X X X | 9 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| | | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3| | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + | Carcinoma, Metastatic, Liver | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3| | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3| | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + | Deep Cervical, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M M M M M M + M M M M M + M M M M M + M + M| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M + M M M M M M M M M M M M M M M| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + M + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3| | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | |__________________________________________________________________________| Peripheral Nerve | + + + | |__________________________________________________________________________| Spinal Cord | + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Liver | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3| | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Ear | + + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Transitional Epithelium, Carcinoma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| | | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma, Multiple | X | 2 | Leukemia Mononuclear | X X X X X X X X X X X | 22 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 17 | Carcinoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tongue | + + | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| | | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | 39 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| | | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 9 | Deep Cervical, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X X X X | 6 | Renal, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M M M M M M M M M M M M M M M M + M M M M| 5 | Leukemia Mononuclear | | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M + M M + M M M M M M M M M M M + M M +| 5 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + M + + + + + + + + + + + + + + + M +| 44 | Leukemia Mononuclear | X X X X X | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 22 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| | | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Thymus | + M + M + + M + + + + + + + + + + + + + + + + M +| 46 | Thymoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X | 3 | Carcinoma, Multiple | X | 1 | Fibroadenoma | X X X X X X X X | 13 | Fibroadenoma, Multiple | X X X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + | 7 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + | 6 | |__________________________________________________________________________|____________| Spinal Cord | + + + | 6 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| | | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Liver | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X X | 11 | |__________________________________________________________________________|____________| Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 2 | |__________________________________________________________________________|____________| Eye | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Transitional Epithelium, Carcinoma | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0| | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0| | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | Bilateral, Pheochromocytoma Benign | X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Polyp Stromal | X X X | Bilateral, Polyp Stromal | X | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0| | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Vagina | + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + +| Deep Cervical, Leukemia Mononuclear | X X X| Pancreatic, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Bronchial | M + M M M M M + + + M + M M M M + M + M M M M M M| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M + M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | M M M M + + + + + M + + + + M + M + + M + + + M +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | M + M + + + + + + + + + + + M + + + M + + M + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0| | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Osteosarcoma | | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Respiratory Epithelium, Adenoma | | |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0| | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Lacrimal Gland | + | |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +| 48 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 22 | |__________________________________________________________________________|____________| Mesentery | + + + + | 6 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | |__________________________________________________________________________|____________| Tongue | + | 3 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 1 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 28 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | Polyp Stromal | X X X | 6 | Bilateral, Polyp Stromal | | 1 | |__________________________________________________________________________|____________| Vagina | | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Deep Cervical, Leukemia Mononuclear | X | 4 | Pancreatic, Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M + + M M + + M M + M M M M M M M M + M M + M| 14 | Leukemia Mononuclear | X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M M M M + M| 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 6 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + M + + M + + + + + + M + + + + M + + + + M| 34 | Leukemia Mononuclear | X X X X X X | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 22 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + M + + M M + + + + + + + M + + + + + + + + + M| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X| 9 | Fibroadenoma, Multiple | X X X | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femur, Osteosarcoma | X | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + | 5 | |__________________________________________________________________________|____________| Spinal Cord | + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Alveolar/Bronchiolar Adenoma | X | 2 | Leukemia Mononuclear | X X X X X | 15 | Osteosarcoma, Metastatic, Bone | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | Respiratory Epithelium, Adenoma | X | 1 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Osteosarcoma, Metastatic, Bone | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X| 1 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + + | 2 | Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma, Metastatic, Bone | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| | DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| | | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X | 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + A + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Mesentery | + + + + + + | Histiocytic Sarcoma | | Leiomyosarcoma, Metastatic, Stomach, | | Glandular | | Mesothelioma Malignant | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | Leiomyosarcoma, Metastatic, Stomach, | | Glandular | | Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Leukemia Mononuclear | X | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant, Metastatic, | | Peritoneum | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Osteosarcoma, Metastatic, Bone | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma, Metastatic, | | Mesentery | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node | + + + + + | Deep Cervical, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M M M M M M M M M M M M + M + + M M + M M M| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M + M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mediastinal | M + M M + + M M M M + + + M M + M M + M + M M M M| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | Leukemia Mononuclear | X X X X X X X X X X | |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + M M M + M M + M + + + + + + + +| Carcinoma | | Fibroadenoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Trichoepithelioma | X | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Fibroma | X X X X | Subcutaneous Tissue, Fibrous | | Histiocytoma, Multiple | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Pelvis, Femur, Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Fibrous Histiocytoma, Metastatic, | | Skin | X | Histiocytic Sarcoma, Metastatic, | | Mesentery | | Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant, Metastatic, | | Peritoneum | | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Osteosarcoma, Metastatic, Bone | X | Mediastinum, Leukemia Mononuclear | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | Leiomyosarcoma, Metastatic, Stomach, | | Glandular | | Mesothelioma Malignant | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Mesentery | | Leukemia Mononuclear | X X | Liposarcoma | X | Pelvis, Transitional Epithelium, | | Carcinoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________|__________________________________________________________________________ | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2| | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + + + + + + + +| 46 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 22 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + | 12 | Histiocytic Sarcoma | X | 1 | Leiomyosarcoma, Metastatic, Stomach, | | | Glandular | X | 1 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Leiomyosarcoma, Metastatic, Stomach, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Glandular | X | 1 | Leukemia Mononuclear | X | 7 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | |__________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant, Metastatic, | | | Peritoneum | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | Pheochromocytoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Benign | X X X X X X X X | 12 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X | 5 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 36 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X | 2 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + +| 40 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + M + M + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X | 20 | Interstitial Cell, Adenoma | X X X X X X | 18 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + | 11 | Deep Cervical, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | X X X | 6 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M + M M M M M M M M M M M + M + M M M M M M M M M| 7 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 12 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M M + + M + M + M + M M + M M + M + + M + M| 19 | Leukemia Mononuclear | X X X X | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 22 | |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + + + M M + M M + M + + + M + M + + + + + + + M| 35 | Carcinoma | X | 1 | Fibroadenoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | Trichoepithelioma | | 1 | Subcutaneous Tissue, Fibroma | X | 5 | Subcutaneous Tissue, Fibrous | | | Histiocytoma, Multiple | | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pelvis, Femur, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 17 | Mesothelioma Malignant, Metastatic, | | | Peritoneum | X | 1 | Osteosarcoma, Metastatic, Bone | | 1 | Mediastinum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Leiomyosarcoma, Metastatic, Stomach, | | | Glandular | X | 1 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| | | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | X | 1 | Leukemia Mononuclear | X X | 4 | Liposarcoma | | 1 | Pelvis, Transitional Epithelium, | | | Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 22 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3| | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X X X X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Mesentery | + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3| | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3| | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Mesothelioma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | |__________________________________________________________________________| Lymph Node | + + + + | Pancreatic, Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M M M M M M M M M M M M + M M M M M + M M M| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M + M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M + M + M + M M + M M + M + + M M M M + + M + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3| | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + M + + M + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + M M + + + + + + M + + + + + + + M + + +| Adenoma, Multiple | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | Fibrous Histiocytoma, Metastatic, | | Skin | | Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Oligodendroglioma Malignant | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3| | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X | Osteosarcoma, Metastatic, Bone | X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pelvis, Transitional Epithelium, | | Carcinoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Adenoma | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Polyp Adenomatous | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X | 12 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 13 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Benign | X X | 3 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + M + + + + + + A + + + + + +| 48 | Adenoma | X X X X | 8 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 30 | Pars Intermedia, Adenoma | X X | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | 32 | Interstitial Cell, Adenoma | X X X X X X X X X | 13 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node | + | 5 | Pancreatic, Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M + M M M M M + M M M M M M M + M M + M M| 6 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M M M M M M M M| 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + M + + + M M M M M M M + + + A + M M + + M| 23 | Leukemia Mononuclear | X | 4 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X | 11 | |__________________________________________________________________________|____________| Thymus | M + + + + + M + M + + + + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + M + + + + + + + M M + + + + +| 43 | Adenoma, Multiple | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibroma | X X X X X X | 7 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femur, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + | 6 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Oligodendroglioma Malignant | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X | 6 | Osteosarcoma, Metastatic, Bone | | 1 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| | | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | Pelvis, Transitional Epithelium, | | | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 13 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2| | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + A + + + + + + + + + + A A + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + A + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | |__________________________________________________________________________| Mesentery | + + + + + + | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2| | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X| Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Penis | + +| __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2| | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Bronchial | M + M M M M M M + M M M M M M M M M M M + M M M +| Leukemia Mononuclear | X X| |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + + M M M + + M + + + + M + + M M + M M| Leukemia Mononuclear | X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2| | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M + + + + M + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X X | Oligodendroglioma Malignant | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X| Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2| | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Urethra | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 14 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 18 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X X | 2 | Pheochromocytoma Benign | X X X| 8 | Bilateral, Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| 31 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Penis | | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| 27 | Interstitial Cell, Adenoma | X X X X X X X | 16 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 11 | Deep Cervical, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X X X | 5 | Renal, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + M + M M M M M M M M M M M M M + + M M| 12 | Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M + + + M M| 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M + M M M M + M M M M M + M M M M + + + + + + + M| 25 | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 14 | |__________________________________________________________________________|____________| Thymus | M M + + + + + + + + + + + + + + + + + + M M + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | X| 1 | Fibroadenoma | X X X X| 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | X | 4 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 2 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Leukemia Mononuclear | X X X X | 7 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Zymbal's Gland | + + | 3 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| | | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Urethra | + | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 14 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + A + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + A + + + + A + + + + + + + + + + +| Fibrosarcoma | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Mesentery | + + + | Carcinoma, Metastatic, Kidney | | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X | Pars Distalis, Ganglioneuroma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 82 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Leukemia Mononuclear | X X | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M M M M M + M M M M M M M M M M M M M + M M| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mediastinal | M + + M + + + + + + + + + + + + + + M + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + M M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibroadenoma | X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Myxoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Carcinoma, Metastatic, Kidney | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma, | | Multiple | | Carcinoma, Metastatic, Kidney | | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Renal Tubule, Carcinoma | X | __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2| | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | Fibrosarcoma | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X X X X| 10 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 11 | Carcinoma, Metastatic, Kidney | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 4 | Pharyngeal, Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Acinus, Adenoma | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X | 7 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X | 9 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + M + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| 29 | Pars Distalis, Ganglioneuroma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 88 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | | 2 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Kidney | X | 1 | Mesothelioma Malignant | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| 32 | Interstitial Cell, Adenoma | X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + | 6 | Deep Cervical, Leukemia Mononuclear | X | 3 | Iliac, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M + M + M M M + M M M M M M M M M M M M M| 5 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M M M M| 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + M M + M M M + + + M + M M +| 38 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X X X X| 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + M M M + + + M + M + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | | 1 | Fibroadenoma, Multiple | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 3 | Subcutaneous Tissue, Fibroma | X X | 3 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Myxoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + | 4 | Carcinoma, Metastatic, Kidney | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 91 NTP Experiment-Test: 88004-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:37:11 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| | | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Multiple | X | 1 | Carcinoma, Metastatic, Kidney | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X X | 6 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | Renal Tubule, Carcinoma | X | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 10 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------