TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
FINAL #1 RATS
Facility: Battelle Northwest
Chemical CAS #: 1321-74-0
Lock Date: 04/16/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 16 14 26
Natural Death 7 3 3 2
Accidently Killed 1
Survivors
Terminal Sacrifice 33 30 33 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%)
Hepatocellular Adenoma, Multiple 2 (4%)
Histiocytic Sarcoma, Metastatic, Spleen 1 (2%)
Mesentery (15) (20) (17) (6)
Carcinoma, Metastatic, Liver 1 (6%)
Pancreas (50) (49) (50) (50)
Tongue (1) (1) (3) (3)
Squamous Cell Papilloma 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Page 2
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 37 (74%) 34 (68%) 39 (78%) 28 (56%)
Thyroid Gland (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
C-Cell, Adenoma 5 (10%) 1 (2%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Carcinoma 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Polyp Stromal 9 (18%) 6 (12%) 8 (16%) 6 (12%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%)
Bilateral, Polyp Stromal 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Vagina (2) (3)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (6) (10) (9) (8)
Deep Cervical, Carcinoma, Metastatic,
Zymbal's Gland 1 (17%)
Pancreatic, Carcinoma, Metastatic, Mammary
Gland 1 (10%)
Pancreatic, Histiocytic Sarcoma, Metastatic,
Page 3
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen 1 (17%)
Lymph Node, Bronchial (8) (9) (5) (14)
Lymph Node, Mandibular (3) (1) (5) (3)
Lymph Node, Mesenteric (50) (50) (50) (50)
Lymph Node, Mediastinal (32) (37) (44) (34)
Carcinoma, Metastatic, Mammary Gland 1 (3%)
Carcinoma, Metastatic, Zymbal's Gland 1 (3%)
Spleen (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Thymus (45) (41) (46) (39)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 3 (6%) 4 (8%) 3 (6%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 14 (28%) 14 (28%) 13 (26%) 9 (18%)
Fibroadenoma, Multiple 6 (12%) 8 (16%) 6 (12%) 5 (10%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Femur, Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Carcinoma, Metastatic, Liver 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Nose (50) (50) (49) (49)
Respiratory Epithelium, Adenoma 1 (2%)
Pleura (50) (50) (50) (49)
Osteosarcoma, Metastatic, Bone 1 (2%)
Trachea (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (49) (49)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Harderian Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (50) (50) (49) (49)
Transitional Epithelium, Carcinoma 1 (2%)
Page 5
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Leukemia Mononuclear 10 (20%) 18 (36%) 22 (44%) 22 (44%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 46 49 47
Total Primary Neoplasms 87 104 107 90
Total Animals with Benign Neoplasms 43 42 45 36
Total Benign Neoplasms 70 74 74 61
Total Animals with Malignant Neoplasms 17 27 28 27
Total Malignant Neoplasms 17 30 33 29
Total Animals with Metastatic Neoplasms 3 2 2 1
Total Metastatic Neoplasm 13 5 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 9 12 13
Natural Death 4 6 6 5
Survivors
Terminal Sacrifice 31 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (48) (48) (48) (49)
Adenoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (47) (48) (46) (49)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (46) (47) (47) (46)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Intestine Small, Ileum (46) (47) (45) (46)
Fibrosarcoma 1 (2%)
Liver (50) (49) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Mesentery (12) (13) (18) (11)
Carcinoma, Metastatic, Kidney 1 (9%)
Histiocytic Sarcoma 1 (8%)
Leiomyosarcoma, Metastatic, Stomach,
Glandular 1 (8%)
Oral Mucosa (1) (1) (4)
Pharyngeal, Squamous Cell Papilloma 1 (25%)
Pancreas (50) (49) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Page 8
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Leiomyosarcoma, Metastatic, Stomach,
Glandular 1 (2%)
Acinus, Adenoma 1 (2%)
Stomach, Forestomach (50) (48) (50) (50)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Stomach, Glandular (50) (48) (50) (49)
Leiomyosarcoma 1 (2%)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Pheochromocytoma Benign 12 (24%) 3 (6%) 8 (16%) 7 (14%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (48) (50) (50)
Adenoma 5 (10%) 8 (17%) 2 (4%) 9 (18%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Adenoma 36 (72%) 30 (60%) 31 (62%) 29 (59%)
Pars Distalis, Ganglioneuroma 1 (2%)
Pars Intermedia, Adenoma 2 (4%)
Thyroid Gland (50) (50) (50) (49)
C-Cell, Adenoma 2 (4%) 5 (10%) 2 (4%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (40) (49) (50) (49)
Carcinoma, Metastatic, Kidney 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (3%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (48) (50) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Seminal Vesicle (50) (49) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 20 (40%) 32 (64%) 27 (54%) 32 (64%)
Interstitial Cell, Adenoma 18 (36%) 13 (26%) 16 (32%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lymph Node (11) (5) (11) (6)
Lymph Node, Bronchial (7) (6) (12) (5)
Lymph Node, Mesenteric (49) (49) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Sarcoma 1 (2%)
Lymph Node, Mediastinal (19) (23) (25) (38)
Carcinoma, Metastatic, Kidney 1 (3%)
Spleen (50) (49) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Thymus (48) (44) (46) (42)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (43) (47) (48)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (3%) 1 (2%)
Fibroadenoma 1 (3%) 5 (11%) 1 (2%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 3 (6%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 7 (14%) 4 (8%) 3 (6%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma,
Multiple 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Myxoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Femur, Osteosarcoma 1 (2%)
Pelvis, Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (2) (6) (1) (4)
Carcinoma, Metastatic, Kidney 1 (25%)
Fibrous Histiocytoma, Metastatic, Skin 1 (17%)
Osteosarcoma 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Astrocytoma Malignant 2 (4%)
Oligodendroglioma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Page 11
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (50) (48) (50) (49)
Pleura (50) (50) (50) (50)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Leiomyosarcoma, Metastatic, Stomach,
Glandular 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (3)
Carcinoma 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (49)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Liposarcoma 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (50) (49) (50) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 22 (44%) 13 (26%) 14 (28%) 10 (20%)
Mesothelioma Malignant 2 (4%) 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 49 49
Total Primary Neoplasms 140 130 125 123
Total Animals with Benign Neoplasms 49 49 48 48
Total Benign Neoplasms 104 107 99 103
Total Animals with Malignant Neoplasms 29 20 24 18
Total Malignant Neoplasms 36 23 26 20
Total Animals with Metastatic Neoplasms 5 3 1 3
Total Metastatic Neoplasm 19 10 1 15
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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