TDMS Study 97013-05 Pathology Tables
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/L
Include 004 175 MG/L
Include 006 350 MG/L
Include 008 700 MG/L
Include 001 0 MG/L
Include 003 175 MG/L
Include 005 350 MG/L
Include 007 700 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Natural Death 4 2 1 1
Moribund Sacrifice 1 3 1
Survivors
Terminal Sacrifice 10 13 11 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Salivary Glands (1) (1)
Duct, Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 2 (13%) 2 (13%) 4 (27%)
Squamous Cell Papilloma, Multiple 1 (7%) 2 (13%) 2 (13%) 2 (13%)
Tooth (3) (2) (4) (2)
Odontogenic Tumor 3 (100%) 2 (100%) 3 (75%) 2 (100%)
Odontogenic Tumor, Multiple 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Vagina (2) (2) (1)
Squamous Cell Papilloma 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (6) (3)
Squamous Cell Papilloma 1 (100%) 4 (67%) 1 (33%)
Squamous Cell Papilloma, Multiple 1 (17%) 2 (67%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 2 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 9 10 9
Total Primary Neoplasms 11 9 13 12
Total Animals with Benign Neoplasms 6 7 7 8
Total Benign Neoplasms 6 7 9 9
Total Animals with Malignant Neoplasms 2 1
Total Malignant Neoplasms 2 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 3 2 4 2
Total Uncertain Neoplasms 3 2 4 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 3 3 1
Survivors
Terminal Sacrifice 13 12 12 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Salivary Glands (1) (2) (1)
Duct, Carcinoma 2 (100%) 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 3 (20%) 5 (33%) 3 (20%)
Squamous Cell Papilloma, Multiple 2 (13%) 2 (13%) 1 (7%) 1 (7%)
Tooth (4) (4) (3) (2)
Odontogenic Tumor 4 (100%) 4 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
Pituitary Gland (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Testes (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Lymph Node, Mandibular (15) (15) (14) (13)
Lymph Node, Mesenteric (15) (15) (15) (15)
Spleen (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (2) (2) (1)
Squamous Cell Papilloma 2 (33%) 2 (100%) 1 (50%)
Squamous Cell Papilloma, Multiple 4 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Carcinoma, Metastatic, Salivary Glands 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: DOSED WATER Time: 08:35:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 11 9 7
Total Primary Neoplasms 15 14 10 8
Total Animals with Benign Neoplasms 9 6 7 5
Total Benign Neoplasms 11 7 7 5
Total Animals with Malignant Neoplasms 3 1
Total Malignant Neoplasms 3 1
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 4 3 2
Total Uncertain Neoplasms 4 4 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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