TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 FINAL #1 RATS Facility: Battelle Northwest Chemical CAS #: 1321-74-0 Lock Date: 04/16/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 10 16 14 26 Natural Death 7 3 3 2 Accidently Killed 1 Survivors Terminal Sacrifice 33 30 33 22 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Liver (50) (50) (50) (50) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 2 (4%) Hepatocellular Adenoma, Multiple 2 (4%) Histiocytic Sarcoma, Metastatic, Spleen 1 (2%) Mesentery (15) (20) (17) (6) Carcinoma, Metastatic, Liver 1 (6%) Pancreas (50) (49) (50) (50) Tongue (1) (1) (3) (3) Squamous Cell Papilloma 1 (100%) 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Carcinoma 1 (2%) Carcinoma, Metastatic, Mammary Gland 1 (2%) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) 1 (2%) Pheochromocytoma Benign 2 (4%) 2 (4%) 3 (6%) 1 (2%) Page 2 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Bilateral, Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (50) (50) (50) (50) Adenoma 1 (2%) 1 (2%) 1 (2%) Carcinoma 1 (2%) Pituitary Gland (50) (50) (50) (50) Pars Distalis, Adenoma 37 (74%) 34 (68%) 39 (78%) 28 (56%) Thyroid Gland (50) (50) (50) (50) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) C-Cell, Adenoma 5 (10%) 1 (2%) 4 (8%) C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (50) (50) (50) Carcinoma 1 (2%) Ovary (50) (50) (50) (50) Granulosa Cell Tumor Benign 1 (2%) Uterus (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma 1 (2%) Polyp Stromal 9 (18%) 6 (12%) 8 (16%) 6 (12%) Sarcoma Stromal 1 (2%) Schwannoma Malignant 1 (2%) Bilateral, Polyp Stromal 1 (2%) Cervix, Sarcoma Stromal 1 (2%) Vagina (2) (3) Sarcoma 1 (50%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (6) (10) (9) (8) Deep Cervical, Carcinoma, Metastatic, Zymbal's Gland 1 (17%) Pancreatic, Carcinoma, Metastatic, Mammary Gland 1 (10%) Pancreatic, Histiocytic Sarcoma, Metastatic, Page 3 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Spleen 1 (17%) Lymph Node, Bronchial (8) (9) (5) (14) Lymph Node, Mandibular (3) (1) (5) (3) Lymph Node, Mesenteric (50) (50) (50) (50) Lymph Node, Mediastinal (32) (37) (44) (34) Carcinoma, Metastatic, Mammary Gland 1 (3%) Carcinoma, Metastatic, Zymbal's Gland 1 (3%) Spleen (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Thymus (45) (41) (46) (39) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma 3 (6%) 4 (8%) 3 (6%) Carcinoma, Multiple 1 (2%) 1 (2%) Fibroadenoma 14 (28%) 14 (28%) 13 (26%) 9 (18%) Fibroadenoma, Multiple 6 (12%) 8 (16%) 6 (12%) 5 (10%) Skin (50) (50) (50) (50) Basal Cell Carcinoma 1 (2%) Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Femur, Osteosarcoma 1 (2%) Vertebra, Osteosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Astrocytoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (49) (50) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) Carcinoma, Metastatic, Liver 1 (2%) Carcinoma, Metastatic, Mammary Gland 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%) Nose (50) (50) (49) (49) Respiratory Epithelium, Adenoma 1 (2%) Pleura (50) (50) (50) (49) Osteosarcoma, Metastatic, Bone 1 (2%) Trachea (50) (50) (50) (50) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (48) (49) (49) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Harderian Gland (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma, Metastatic, Zymbal's Gland 1 (2%) Zymbal's Gland (1) (2) Carcinoma 1 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Osteosarcoma, Metastatic, Bone 1 (2%) Urinary Bladder (50) (50) (49) (49) Transitional Epithelium, Carcinoma 1 (2%) Page 5 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 2 (4%) Leukemia Mononuclear 10 (20%) 18 (36%) 22 (44%) 22 (44%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 46 46 49 47 Total Primary Neoplasms 87 104 107 90 Total Animals with Benign Neoplasms 43 42 45 36 Total Benign Neoplasms 70 74 74 61 Total Animals with Malignant Neoplasms 17 27 28 27 Total Malignant Neoplasms 17 30 33 29 Total Animals with Metastatic Neoplasms 3 2 2 1 Total Metastatic Neoplasm 13 5 3 3 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 15 9 12 13 Natural Death 4 6 6 5 Survivors Terminal Sacrifice 31 35 31 32 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (48) (48) (48) (49) Adenoma 1 (2%) Polyp Adenomatous 1 (2%) Intestine Large, Cecum (47) (48) (46) (49) Polyp Adenomatous 1 (2%) Intestine Small, Jejunum (46) (47) (47) (46) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Intestine Small, Ileum (46) (47) (45) (46) Fibrosarcoma 1 (2%) Liver (50) (49) (50) (50) Carcinoma, Metastatic, Islets, Pancreatic 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (2%) Mesentery (12) (13) (18) (11) Carcinoma, Metastatic, Kidney 1 (9%) Histiocytic Sarcoma 1 (8%) Leiomyosarcoma, Metastatic, Stomach, Glandular 1 (8%) Oral Mucosa (1) (1) (4) Pharyngeal, Squamous Cell Papilloma 1 (25%) Pancreas (50) (49) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Page 8 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Leiomyosarcoma, Metastatic, Stomach, Glandular 1 (2%) Acinus, Adenoma 1 (2%) Stomach, Forestomach (50) (48) (50) (50) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Stomach, Glandular (50) (48) (50) (49) Leiomyosarcoma 1 (2%) Tongue (1) (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Adrenal Medulla (50) (50) (50) (50) Osteosarcoma, Metastatic, Bone 1 (2%) Pheochromocytoma Malignant 1 (2%) 2 (4%) 2 (4%) 1 (2%) Pheochromocytoma Benign 12 (24%) 3 (6%) 8 (16%) 7 (14%) Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) Islets, Pancreatic (50) (48) (50) (50) Adenoma 5 (10%) 8 (17%) 2 (4%) 9 (18%) Carcinoma 1 (2%) 1 (2%) 1 (2%) Pituitary Gland (50) (50) (50) (49) Pars Distalis, Adenoma 36 (72%) 30 (60%) 31 (62%) 29 (59%) Pars Distalis, Ganglioneuroma 1 (2%) Pars Intermedia, Adenoma 2 (4%) Thyroid Gland (50) (50) (50) (49) C-Cell, Adenoma 2 (4%) 5 (10%) 2 (4%) 2 (4%) C-Cell, Carcinoma 1 (2%) 1 (2%) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 9 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (40) (49) (50) (49) Carcinoma, Metastatic, Kidney 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (3%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Preputial Gland (48) (50) (50) (49) Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) 1 (2%) Prostate (50) (50) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Seminal Vesicle (50) (49) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Testes (50) (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 20 (40%) 32 (64%) 27 (54%) 32 (64%) Interstitial Cell, Adenoma 18 (36%) 13 (26%) 16 (32%) 10 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) Lymph Node (11) (5) (11) (6) Lymph Node, Bronchial (7) (6) (12) (5) Lymph Node, Mesenteric (49) (49) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Sarcoma 1 (2%) Lymph Node, Mediastinal (19) (23) (25) (38) Carcinoma, Metastatic, Kidney 1 (3%) Spleen (50) (49) (50) (50) Carcinoma, Metastatic, Kidney 1 (2%) Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Thymus (48) (44) (46) (42) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (35) (43) (47) (48) Adenoma, Multiple 1 (2%) Carcinoma 1 (3%) 1 (2%) Fibroadenoma 1 (3%) 5 (11%) 1 (2%) Fibroadenoma, Multiple 1 (2%) Skin (50) (50) (50) (50) Basal Cell Adenoma 1 (2%) 3 (6%) Squamous Cell Papilloma 1 (2%) Trichoepithelioma 1 (2%) Subcutaneous Tissue, Fibroma 5 (10%) 7 (14%) 4 (8%) 3 (6%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibrous Histiocytoma, Multiple 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) 1 (2%) Subcutaneous Tissue, Myxoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Femur, Osteosarcoma 1 (2%) Pelvis, Femur, Osteosarcoma 1 (2%) Skeletal Muscle (2) (6) (1) (4) Carcinoma, Metastatic, Kidney 1 (25%) Fibrous Histiocytoma, Metastatic, Skin 1 (17%) Osteosarcoma 1 (17%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (50) (50) (50) Astrocytoma Malignant 2 (4%) Oligodendroglioma Malignant 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) Carcinoma, Metastatic, Kidney 1 (2%) Page 11 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Fibrous Histiocytoma, Metastatic, Skin 1 (2%) 1 (2%) 1 (2%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Squamous Cell Carcinoma 1 (2%) Nose (50) (48) (50) (49) Pleura (50) (50) (50) (50) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Leiomyosarcoma, Metastatic, Stomach, Glandular 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) (3) Carcinoma 2 (67%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (49) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Liposarcoma 1 (2%) Pelvis, Transitional Epithelium, Carcinoma 1 (2%) 1 (2%) Renal Tubule, Carcinoma 2 (4%) Urinary Bladder (50) (49) (50) (49) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 22 (44%) 13 (26%) 14 (28%) 10 (20%) Mesothelioma Malignant 2 (4%) 2 (4%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 12 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:42:59 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 49 49 49 Total Primary Neoplasms 140 130 125 123 Total Animals with Benign Neoplasms 49 49 48 48 Total Benign Neoplasms 104 107 99 103 Total Animals with Malignant Neoplasms 29 20 24 18 Total Malignant Neoplasms 36 23 26 20 Total Animals with Metastatic Neoplasms 5 3 1 3 Total Metastatic Neoplasm 19 10 1 15 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 13 ------------------------------------------------------------ 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