TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
FINAL #1 RATS
Facility: Battelle Northwest
Chemical CAS #: 1321-74-0
Lock Date: 04/16/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 1 2 3 |
Hepatodiaphragmatic Nodule | 4 4 |
Vacuolization Cytoplasmic | 2 3 2 |
Periportal, Inflammation, Chronic | 2 |
Portal, Bile Stasis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Necrosis | 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Ulcer | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 1 4 2 4 1 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 4 |
Hyperplasia | 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Bilateral, Cyst | 3|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M M M + M M M M M M M + M M + M M M M M +|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M + + M + + M M M M + + + M + + + M + M|
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Fibrosis | 3 3 3 |
Hemorrhage | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 2 4 |
Hemorrhage | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 4 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolar Epithelium, Hypertrophy | 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Mediastinum, Necrosis, Fatty | 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | 3 2 1 |
Ulcer | |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 1 2 1 1 2 1 |
Olfactory Epithelium, Regeneration, | |
Focal | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 3 1 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Cornea, Inflammation | 2 |
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 1 2 1 2 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|
DAY ON TEST | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|
| 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cortex, Renal Tubule, Hyperplasia | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Pelvis, Transitional Epithelium, | |
Mineralization | 2 |
Renal Tubule, Dilatation | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | 2 | 5 2.0|
Hepatodiaphragmatic Nodule | 4 4 4 | 5 4.0|
Vacuolization Cytoplasmic | 1| 4 2.0|
Periportal, Inflammation, Chronic | 2 3 | 3 2.3|
Portal, Bile Stasis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 15 |
Necrosis | 3 3 3 3 3 3 3 | 14 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Pharyngeal, Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 | 3 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 1 2 1 4 1 1| 14 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 4 3 | 6 3.5|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | 3 3| 4 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia | 3 3 2 4 | 5 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 | 3 3.7|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 4| 5 3.6|
Bilateral, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M M + M M M + M M M M M M + M M M M| 8 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M + M M M M M M + M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + M M + M + + M + + M M| 32 |
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Histiocyte | 3 | 2 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 2 |
Fibrosis | | 3 3.0|
Hemorrhage | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + M + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 4 2 3 | 9 3.1|
Hemorrhage | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Metaplasia, Squamous | 2| 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 2 2 1 2 1 1 2 1 1 1 2 2 1 2 | 27 1.3|
Alveolar Epithelium, Hyperplasia | 4 2 | 4 2.3|
Alveolar Epithelium, Hypertrophy | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 2 1 1 1 | 8 1.1|
Mediastinum, Necrosis, Fatty | | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 3.0|
Inflammation, Suppurative | 4 2 | 5 2.4|
Ulcer | 4 | 1 4.0|
Goblet Cell, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 3 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 | 10 1.5|
Olfactory Epithelium, Regeneration, | | |
Focal | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 2 | 5 1.8|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Cornea, Inflammation | | 1 2.0|
Lens, Cataract | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 1 1 1 3 1 2 1| 19 1.4|
Cortex, Renal Tubule, Hyperplasia | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Mineralization | | 1 2.0|
Renal Tubule, Dilatation | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Epithelium, Metaplasia, Focal, | |
Squamous | 3 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X 3 X 3 |
Hepatodiaphragmatic Nodule | 4 4 4 4 4|
Vacuolization Cytoplasmic | |
Hepatocyte, Regeneration | 4 |
Periportal, Inflammation, Chronic | 2 |
Portal, Bile Stasis | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Necrosis | 3 3 3 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Acinus, Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Ulcer | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 1 |
Pars Distalis, Hyperplasia | 3 2 4 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 4 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Endometrium, Hyperplasia | 2 |
|__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Infiltration Cellular,| |
Histiocyte | 3 3 |
Pancreatic, Pigmentation | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + M M M M M M M M M M M + + M M M + M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M + M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M + M M + + + + M + + + + + + + + + + M M|
Infiltration Cellular, Histiocyte | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 4 |
Hyperplasia, Focal, Lymphoid | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Fracture | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 2 3 |
Congestion | |
Hemorrhage | 4 4 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + I |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Chronic, Focal | 1 2 1 2 2 2 1 1 2 3 2 1|
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolar Epithelium, Hypertrophy | 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 3 2|
Inflammation, Suppurative | 1 2 2 2 2 3 2 1 |
Glands, Dilatation | 2 1 2 1 1 2 2 1 1|
Goblet Cell, Hyperplasia | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 2 1 1 2 2 1 2 1 2 1 1 2 2 1 1 2 2 2 2 1 2 2 2 2 2|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2|
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + I + + + + + + A + + + + + + +|
Ciliary Body, Inflammation | |
Lens, Cataract | 3 4 1|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|
| 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 2 1 1 1 1 |
Cortex, Renal Tubule, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 19
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Metaplasia, Focal, | | |
Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | 2 2 2 | 7 2.4|
Hepatodiaphragmatic Nodule | 4 4 | 7 4.0|
Vacuolization Cytoplasmic | 3 2 4 | 3 3.0|
Hepatocyte, Regeneration | | 1 4.0|
Periportal, Inflammation, Chronic | 4 | 2 3.0|
Portal, Bile Stasis | 4 3 4 | 3 3.7|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + +| 20 |
Necrosis | 3 3 3 3 3 3 3 3 3 3| 20 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 1 1 2 | 5 1.2|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Squamous | 4 | 1 4.0|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 1 3 | 5 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 4 | 6 2.8|
Pars Distalis, Hyperplasia | 3 3 3 2| 8 2.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | 2 4 1 2 | 8 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4| 3 4.0|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 | 6 2.7|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
Endometrium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Vagina | + | 2 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Deep Cervical, Infiltration Cellular,| | |
Histiocyte | 4 | 3 3.3|
Pancreatic, Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M + M M M + M M M M + M + M M M M + M| 9 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M + + + + M + + M + + + + + + + + + + + +| 37 |
Infiltration Cellular, Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Focal, Lymphoid | 4 | 2 3.5|
|__________________________________________________________________________|____________|
Thymus | + M M M + + M + + M + + M + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 2 4.0|
Hyperkeratosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Fracture | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Inflammation, Chronic | 4 | 1 4.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 3 3 3 4 4 | 10 3.1|
Congestion | 1 | 1 1.0|
Hemorrhage | | 2 4.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 | 22 1.4|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolar Epithelium, Hypertrophy | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 3 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 5 2.0|
Inflammation, Suppurative | 1 1 2 1 | 12 1.7|
Glands, Dilatation | 1 1 1 2 1 1 1 1| 17 1.3|
Goblet Cell, Hyperplasia | 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 1 1 1 1 | 14 1.1|
Olfactory Epithelium, Degeneration | 1 1 1 2 2 1 1 2 1 2 2 1 2 2 1 2 1 1 2 1 1 1 2 1 2| 50 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3| |
| 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ciliary Body, Inflammation | 2 | 1 2.0|
Lens, Cataract | | 3 2.7|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 1 1 2 1 1 1 1 1 2 2 1 2 | 21 1.3|
Cortex, Renal Tubule, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 4 2 4 |
Hepatodiaphragmatic Nodule | 4 4 |
Necrosis | 3 |
Bile Duct, Hyperplasia | 4 |
Hepatocyte, Regeneration | |
Periportal, Inflammation, Chronic | 2 |
Portal, Bile Stasis | 4 |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Necrosis | 4 3 3 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Erosion | 2 |
Ulcer | 4 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 4 |
Pulp, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 4 |
Vacuolization Cytoplasmic | 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 4 4 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Endometrium, Hyperplasia | |
Myometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Pigmentation | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M + M M M M M + M M M M M + M + M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M + M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + M + + + + M + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Accessory Spleen | |
Fibrosis | 3 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tibia, Fracture | |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 4 3 3 |
Hemorrhage | 4 3 4 1 |
Infarct | |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 4 4 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Foreign Body | 2 |
Hemorrhage | |
Inflammation, Chronic, Focal | 2 1 1 2 1 2 4 1 1 1 1 1 1 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 1 2 2 1 |
Glands, Dilatation | 2 1 1 2 1 1 1 2 2 1 1 1 2 1 1 1 1 1|
Goblet Cell, Hyperplasia | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 3|
Nasopharyngeal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 |
Olfactory Epithelium, Degeneration | 2 1 2 2 2 2 1 2 1 1 2 1 2 2 2 2 2 2 1 2 2 1 2 2 2|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 2 1 1 1 1 1 1 1 1 2 2 2 2 1 1 1 2 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 |
Respiratory Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|
| 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Anterior Chamber, Hemorrhage | |
Lens, Cataract | 4 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 3 1 1 1 3 2 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 31
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X 1 | 6 2.8|
Hepatodiaphragmatic Nodule | 4 4 1 4 | 6 3.5|
Necrosis | | 1 3.0|
Bile Duct, Hyperplasia | | 1 4.0|
Hepatocyte, Regeneration | 4 | 1 4.0|
Periportal, Inflammation, Chronic | | 1 2.0|
Portal, Bile Stasis | 3 | 2 3.5|
Serosa, Fibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Necrosis | 3 3 3 3 4 3 3 3 3 | 16 3.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia, Focal, Squamous | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Tongue | + + | 3 |
Epithelium, Hyperplasia | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 4.0|
Pulp, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 4.0|
Vacuolization Cytoplasmic | 2 2 3 1 | 7 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 5 2.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 3 2 4| 4 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 1 2 2 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Hyperplasia | 3 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 4 4 3 4| 11 3.2|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia | 3 | 1 3.0|
Myometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
Pancreatic, Pigmentation | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M M M M M M M M M M M M M + M M M M| 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M + M M + M M M M M M M M M M M + M M +| 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + M + + + + + + + + + + + + + + + M +| 44 |
Fibrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 4 | 3 3.3|
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + M + M + + M + + + + + + + + + + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tibia, Fracture | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Skeletal Muscle | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 2 4 3 2 3 | 11 2.9|
Hemorrhage | 4 1 | 6 2.8|
Infarct | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 6 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 3 4.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Foreign Body | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 2 1 1 1 2 1 1 | 26 1.3|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 2 1 | 6 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 | 1 3.0|
Inflammation, Suppurative | 1 1 1 1 | 8 1.3|
Glands, Dilatation | 1 2 2 1 2 1 1 1 1 1 1 1 1 1 2 2 2 2 2 1| 38 1.3|
Goblet Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 3 2.3|
Nasopharyngeal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 1 1 1 1 1 1 1 1| 15 1.1|
Olfactory Epithelium, Degeneration | 2 2 3 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 2| 49 1.8|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1 2 1 1 1 1 2| 42 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 | 4 1.3|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Degeneration, Cystic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
|__________________________________________________________________________|____________|
Eye | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
Anterior Chamber, Hemorrhage | 4 | 1 4.0|
Lens, Cataract | 4 4| 4 3.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Nephropathy, Chronic | 1 2 2 4 3 1 2 1 1 1 | 19 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1| |
| 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatodiaphragmatic Nodule | 4 4 4 4 4 4 4|
Vacuolization Cytoplasmic | 2 3 1 |
Periportal, Inflammation, Chronic | |
Portal, Bile Stasis | |
|__________________________________________________________________________|
Mesentery | + + |
Necrosis | 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | 4 |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Pericardium, Infiltration Cellular, | |
Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 2 2 2 2 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 |
Pars Distalis, Hematocyst | |
Pars Distalis, Hyperplasia | 3 3 1 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | 1 |
|__________________________________________________________________________|
Vagina | + + + |
Muscularis, Hypertrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + +|
Deep Cervical, Infiltration Cellular,| |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M M M + + + M + M M M M + M + M M M M M M|
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + + + + + M + + + + M + M + + M + + + M +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Hemorrhage | |
Necrosis | |
|__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + M + + + M + + M + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 3|
Hemorrhage | 4 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 1 1 2 1 1 2 1 1 1 2 2 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Hypertrophy | 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 1|
Interstitium, Fibrosis | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Glands, Dilatation | 2 1 2 1 2 1 1 2 1 2 2 2 2 2 2 2 1 1 2 1 2 2 2 2|
Goblet Cell, Hyperplasia | 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Olfactory Epithelium, Degeneration | 2 2 1 2 2 1 3 2 2 1 2 2 2 2 2 2 2 3 3 1 3 2 3 3|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 4 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4|
Bilateral, Cortex, Renal Tubule, | |
Degeneration | |
Cortex, Infarct | |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|
| 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Medulla, Renal Tubule, Degeneration | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 44
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + A +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatodiaphragmatic Nodule | 4 4 | 9 4.0|
Vacuolization Cytoplasmic | | 3 2.0|
Periportal, Inflammation, Chronic | 2 1 | 2 1.5|
Portal, Bile Stasis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Necrosis | 3 3 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 4 2.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Erosion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tongue | + | 3 |
Epithelium, Hyperplasia | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 | 3 1.7|
Pericardium, Infiltration Cellular, | | |
Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 2 1 2 | 12 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 2 | 5 2.8|
Pars Distalis, Hematocyst | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 2 | 7 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2| 4 2.8|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Vagina | | 3 |
Muscularis, Hypertrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Deep Cervical, Infiltration Cellular,| | |
Histiocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M + + M M + M M M M M M M M + M M + M| 14 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M M M M + M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + M + + M + + + + + + M + + + + M + + + + M| 34 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hemorrhage | 4 4 | 2 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + M + + M M + + + + + + + M + + + + + + + + + M| 39 |
Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 1 4.0|
Inflammation, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 | 7 3.1|
Hemorrhage | 3 4 | 3 3.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1| 33 1.2|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Alveolar Epithelium, Hypertrophy | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 1 1 | 5 1.2|
Interstitium, Fibrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Inflammation, Suppurative | 2 2 1 2 | 7 1.6|
Glands, Dilatation | 2 1 2 1 1 2 1 2 1 3 2 2 1 2 2 1 1 2 2 2| 44 1.7|
Goblet Cell, Hyperplasia | 2 | 4 1.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1| 4 1.0|
Olfactory Epithelium, Degeneration | 2 2 3 2 1 2 1 1 2 3 2 2 2 2 2 2 2 3 2 2 1 2 2 3| 48 2.0|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 1 2 2 1 1 2 1 2 1 2 1 2 1 2 2 2 2 1 2 2 2| 45 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Degeneration, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| |
DAY ON TEST | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| |
| 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Lens, Cataract | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 3 1 1 2 4 1| 10 2.2|
Bilateral, Cortex, Renal Tubule, | | |
Degeneration | 4 | 1 4.0|
Cortex, Infarct | 1 3 | 2 2.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 4 | 1 4.0|
Medulla, Renal Tubule, Degeneration | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X 1 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 4 |
Necrosis | 4 |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 4 1 3 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Hyperplasia, Squamous | 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 3 2 1 1 |
Duct, Cyst | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Vacuolization Cytoplasmic | 2 2 2 2 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 4 4 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 4 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 4 4 4 4 3 4 |
Interstitial Cell, Hyperplasia | 2 2 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Angiectasis | |
Deep Cervical, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M M M + M + + M M + M M M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M + M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M + + M M M M + + + M M + M M + M + M M M M|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Necrosis | |
Lymphocyte, Hyperplasia, Diffuse | 2 |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M M M + M M + M + + + + + + + +|
Galactocele | 4 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cartilage, Femur, Hyperplasia | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + +|
Compression | 2 4 3 2 3 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 1 1 |
Inflammation, Suppurative | |
Necrosis | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 2 2 2 |
Interstitium, Fibrosis | 2 |
Mediastinum, Abscess | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Inflammation, Suppurative | 3 2 1 |
Glands, Dilatation | |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 3 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|
| 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 1 1 1 1 1 2 2 1 1 1 4 2 1 1 2 2|
Cortex, Infarct | |
Cortex, Renal Tubule, Hyperplasia | 2 |
Cortex, Renal Tubule, Hypertrophy | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 |
Hemorrhage | 4 |
__________________________________________|__________________________________________________________________________
Page 56
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 2 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | 4 | 2 4.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Necrosis | 3 3 | 7 2.9|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Gingival, Hyperplasia, Squamous | | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 3 1 4 1 2 2 1 1 | 15 1.8|
Duct, Cyst | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 1 2.0|
Ulcer | 3 4 1 | 4 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 7 1.6|
Atrium, Thrombosis | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Vacuolization Cytoplasmic | 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 3 4 3 | 12 3.2|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + + + + + +| 46 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cyst | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 3 1 | 5 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + M + M + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 3 | 1 3.0|
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 3 | 5 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 4 4 4| 16 3.9|
Interstitial Cell, Hyperplasia | 4 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Deep Cervical, Angiectasis | 4 | 1 4.0|
Deep Cervical, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M M M M M M M M M + M + M M M M M M M M M| 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M + + M + M + M + M M + M M + M + + M + M| 19 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 3 | 2 3.5|
Necrosis | 4 4 4 | 3 4.0|
Lymphocyte, Hyperplasia, Diffuse | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + M M + M M + M + + + M + M + + + + + + + M| 35 |
Galactocele | 4 | 3 3.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 4 4 | 4 4.0|
Hyperkeratosis | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cartilage, Femur, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 4 3 2 3 3| 10 2.9|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Foreign Body | | 1 4.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 3.0|
Inflammation, Chronic, Focal | 1 1 | 4 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 2 | 1 2.0|
Thrombosis | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 1 4 | 4 2.5|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 1 2 1 1 | 9 1.6|
Interstitium, Fibrosis | | 1 2.0|
Mediastinum, Abscess | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 2 2 | 5 2.0|
Inflammation, Suppurative | 3 3 | 5 2.4|
Glands, Dilatation | 1 2 2 | 3 1.7|
Goblet Cell, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0| |
| 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Suppurative | 1 1 | 2 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1| 4 1.3|
Respiratory Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Degeneration, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | | 2 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 4 2 2 1 3 4 3 1 1 2 1 2 4 1 1 1 1| 37 1.8|
Cortex, Infarct | 4 | 1 4.0|
Cortex, Renal Tubule, Hyperplasia | | 1 2.0|
Cortex, Renal Tubule, Hypertrophy | | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | 2 2 2 | 4 2.0|
Hemorrhage | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + + +|
Necrosis | |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + + +|
Dilatation | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 2 3 |
Hepatodiaphragmatic Nodule | 4 |
Inflammation, Granulomatous | 3 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Necrosis | 3 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 2 1 2 1 4 1 2 |
Acinus, Inflammation | 2 |
Duct, Cyst | 3 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Suppurative | 1 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | 4 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 |
Atrium, Thrombosis | 4 |
Pericardium, Epicardium, | |
Infiltration Cellular, Histiocyte| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Vacuolization Cytoplasmic | 1 2 1 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 2 2 2 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Pars Distalis, Hematocyst | 4 |
Pars Distalis, Hyperplasia | 2 3 3 2 1 1 3 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 2 3 3 |
Interstitial Cell, Hyperplasia | 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Cyst | 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M M M M M M M + M M M M M + M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | M M M M + M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + M + M M + M M + M + + M M M M + + M + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 4 3 3 |
Hemorrhage | 4 4 |
Hyperplasia, Focal, Lymphoid | 3 |
Necrosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + M + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M M + + + + + + M + + + + + + + M + + +|
Galactocele | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture | 4 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 2 2 |
Alveolar Epithelium, Hyperplasia | 1 1 3 2 1 2 |
Alveolar Epithelium, Hypertrophy | 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 3 1 1 |
Interstitium, Fibrosis | 1 |
|__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | 3 1 1 1 1 2 |
Glands, Dilatation | 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 2 2 2|
Goblet Cell, Hyperplasia | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 2 |
Olfactory Epithelium, Degeneration | 2 1 1 1 1 1 1 2 1 2 2 2 1 2 2 2 2 1 2 2 2 1 2 2|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Turbinate, Cyst | 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|
| 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 1 1 1 1 2 2 1 1 2 2 2 1 1 1 2 1 1 1 1 1|
Cortex, Infarct | 2 |
Cortex, Renal Tubule, Hyperplasia | |
Medulla, Infarct | |
Medulla, Infiltration Cellular, | |
Lipocyte | 3|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | 4 |
__________________________________________|__________________________________________________________________________
Page 68
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Dilatation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Clear Cell Focus | 3 X | 5 2.5|
Hepatodiaphragmatic Nodule | 4 | 2 4.0|
Inflammation, Granulomatous | | 1 3.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 | 2 2.0|
Serosa, Fibrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 13 |
Necrosis | 3 3 3 3 3 3 2 3 | 13 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Acinus, Atrophy | 1 2 1 3 1 4 | 18 1.8|
Acinus, Inflammation | | 1 2.0|
Duct, Cyst | | 2 2.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Diverticulum | 3 | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Erosion | 3 | 2 2.5|
Ulcer | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 5 2.2|
Atrium, Thrombosis | | 1 4.0|
Pericardium, Epicardium, | | |
Infiltration Cellular, Histiocyte| 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 2 | 2 2.5|
Vacuolization Cytoplasmic | 1 2 2 | 8 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 3 3 2 3 | 13 2.7|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + A + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Pars Distalis, Hematocyst | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 8 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 2 2 | 4 3.0|
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Hyperplasia | 4 4 4 3 | 4 3.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Germinal Epithelium, Atrophy | 3 3 3 4 3 3 3 3 | 12 3.1|
Interstitial Cell, Hyperplasia | 3 3 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Deep Cervical, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M + M M M M M + M M M M M M M + M M + M M| 6 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M + M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Ectasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + M + + + M M M M M M M + + + A + M M + + M| 23 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Accessory Spleen | X X | 3 |
Fibrosis | 3 3 | 6 3.2|
Hemorrhage | | 2 4.0|
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + M + M + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + M M + + + + +| 43 |
Galactocele | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Cyst Epithelial Inclusion | | 1 4.0|
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fracture | | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 2 3 2| 5 2.4|
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Foreign Body | 4 | 2 4.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic, Focal | 1 1 | 4 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 | 8 1.8|
Alveolar Epithelium, Hypertrophy | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 1 2 1 3 2 1 1| 12 1.6|
Interstitium, Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Foreign Body | | 1 3.0|
Inflammation, Suppurative | 1 2 1 | 9 1.4|
Glands, Dilatation | 1 1 1 1 1 1 1 1 2 1 1 | 30 1.2|
Goblet Cell, Hyperplasia | 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 | 6 1.7|
Olfactory Epithelium, Degeneration | 1 2 2 2 1 1 2 1 1 2 2 1 2 1 2 2 2 1 1 2 2 1 1| 47 1.6|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 1 1 1 1 1 1 1 | 21 1.0|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Turbinate, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Nephropathy, Chronic | 4 1 1 3 3 1 1 1 2 1 1 2 2 2 1 3 3 2 1 1| 41 1.5|
Cortex, Infarct | | 1 2.0|
Cortex, Renal Tubule, Hyperplasia | 1 1 | 2 1.0|
Medulla, Infarct | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5| |
| 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Medulla, Infiltration Cellular, | | |
Lipocyte | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Calculus Micro Observation Only | 3 2 | 2 2.5|
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + A + + + + + + + + + + A A + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 4 |
Hepatodiaphragmatic Nodule | 4 4 |
Necrosis | 4 2|
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | |
Hepatocyte, Regeneration | 4|
Periportal, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 3 3 3 2 2 3 |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4|
Acinus, Atrophy | 1 1 1 2 2 4 1 3 1 1 1 2 1 3 2 1|
Acinus, Hyperplasia | 3 |
Duct, Cyst | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 4 |
Pericardium, Inflammation | 3 |
Pericardium, Pigmentation | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Pars Distalis, Hyperplasia | 2 3 2 1 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 4 1 3 3 4 2|
Follicular Cell, Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + +|
Inflammation | 4|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 4|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
Germinal Epithelium, Atrophy | 3 4 2 3 4 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Hemorrhage | 3 |
Pancreatic, Ectasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M M M M + M M M M M M M M M M M + M M M +|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + M M M + + M + + + + M + + M M + M M|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 |
Hemorrhage | 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M + + + + M + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | |
Inflammation, Acute | 4 4 |
Ulcer | 4 3 |
Subcutaneous Tissue, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 4 |
Inflammation, Suppurative | 4 |
Epiglottis, Metaplasia, Squamous | 3 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 1 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 3|
Necrosis | |
Alveolar Epithelium, Hyperplasia | 2 1 3 1 2 |
Alveolar Epithelium, Hypertrophy | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 2 2 1 1 2 1 1 |
Interstitium, Fibrosis | 1 |
Mediastinum, Inflammation, Chronic | 2 |
Mediastinum, Pigmentation | 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 |
Inflammation, Suppurative | 1 1 1 2 1 3 1 2 2 2 2 2 2|
Glands, Dilatation | 1 1 1 1 2 2 2 1 2 1 2 2 1 1 2 1 2 2 1 1 2 2 2|
Goblet Cell, Hyperplasia | 1 2 3 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Nasopharyngeal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Degeneration | 2 2 1 2 2 2 2 1 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|
| 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 2 2 2 1 2 2 2 2 2 1 2 1 1 2 1 2 1 1 2 2 2 1|
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + A + A + + + + + + + + + + + + + + + +|
Anterior Chamber, Hemorrhage | |
Lens, Cataract | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Zymbal's Gland | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 4 1 3 2 2 1 1 2 1 1 1 3 3 2 2 2|
|__________________________________________________________________________|
Urethra | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 4|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 81
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Clear Cell Focus | | 1 4.0|
Hepatodiaphragmatic Nodule | 4 4 | 4 4.0|
Necrosis | 1 | 3 2.3|
Vacuolization Cytoplasmic | 3 2 | 3 2.7|
Bile Duct, Hyperplasia | 2 2 2 | 3 2.0|
Hepatocyte, Regeneration | | 1 4.0|
Periportal, Inflammation, Chronic | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + +| 18 |
Necrosis | 3 3 3 3 3 3 3 3 3 3 3 3| 18 2.9|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 4.0|
Acinus, Atrophy | 1 1 2 3 1 3 1 3 2 1 1 | 27 1.7|
Acinus, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Duct, Cyst | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 2 2.5|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Atrium, Thrombosis | 4 | 2 4.0|
Pericardium, Inflammation | | 1 3.0|
Pericardium, Pigmentation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 1 1 | 7 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 2 1 3| 8 2.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Pars Distalis, Hyperplasia | 4 3 1 4 | 9 2.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 | 9 2.6|
Follicular Cell, Hyperplasia | 1 4 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 4.0|
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 4 4 | 4 3.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | 3 3 | 2 3.0|
Germinal Epithelium, Atrophy | 2 4 3 4 4 | 11 3.3|
Interstitial Cell, Hyperplasia | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 11 |
Deep Cervical, Hemorrhage | | 1 3.0|
Pancreatic, Ectasia | 3 | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + M + M M M M M M M M M M M M M + + M M| 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M + + + M M| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M + M M M M M + M M M M + + + + + + + M| 25 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 2 | 4 3.3|
Hemorrhage | | 1 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + + + + + + + + + + M M + + +| 46 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Galactocele | 4 4 4 | 6 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperkeratosis | 4 3 | 2 3.5|
Inflammation, Acute | | 2 4.0|
Ulcer | | 2 3.5|
Subcutaneous Tissue, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 3 3 3 | 8 2.9|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 3 4.0|
Inflammation, Suppurative | | 1 4.0|
Epiglottis, Metaplasia, Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 4 1.8|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Focal | 1 1 1 4 | 5 1.6|
Inflammation, Chronic | | 1 3.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia | 1 | 6 1.7|
Alveolar Epithelium, Hypertrophy | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 2 1 | 11 1.5|
Interstitium, Fibrosis | | 1 1.0|
Mediastinum, Inflammation, Chronic | | 1 2.0|
Mediastinum, Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 3 1.7|
Inflammation, Suppurative | 2 2 1 2 | 17 1.7|
Glands, Dilatation | 1 1 2 2 1 1 2 1 1 2 2 2 1 2 1 1 1 1 2 1 2 2 2 1 1| 48 1.5|
Goblet Cell, Hyperplasia | 1 2 | 7 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 1 1.0|
Nasopharyngeal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 2 1.0|
Olfactory Epithelium, Degeneration | 1 2 2 2 1 1 2 1 1 1 1 2 1 1 1 2 1 2 2 1 2 2 1 1 2| 49 1.7|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1 1| 44 1.4|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Anterior Chamber, Hemorrhage | 4 | 1 4.0|
Lens, Cataract | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3| |
| 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 4 2 2 1 2 2 4 1 1 2 1 1 2 3 3 2 4 2 2 3 3| 41 2.1|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | 4 X | 4 3.3|
Hemorrhage | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + A + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 4 |
Hepatodiaphragmatic Nodule | 4 4 4 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 |
Serosa, Fibrosis | |
Serosa, Hemorrhage | |
|__________________________________________________________________________|
Mesentery | + + + |
Necrosis | 3 3 3 |
Fat, Hemorrhage | |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Cyst | 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 3 2 1 1 3 2 2 2 4 2 3 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 2 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 1 3 2 2 3 |
Bilateral, Hyperplasia | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 3 2 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 3 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 3 4 3 |
Interstitial Cell, Hyperplasia | 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Angiectasis | |
Pancreatic, Hemorrhage | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M + M M M M M M M M M M M M M + M M|
Hemorrhage | 3 |
Infiltration Cellular | 3 |
Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 4 3 3 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 4 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Galactocele | 4 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
Gliosis | |
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Inflammation, Suppurative | |
Epiglottis, Metaplasia, Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 |
Inflammation, Chronic, Focal | 1 1 1 1 2 1 1 |
Alveolar Epithelium, Hyperplasia | 4 2 3 |
Alveolar Epithelium, Hypertrophy | 1 |
Alveolus, Hypertrophy | 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 2 1 |
Interstitium, Fibrosis | 1 |
Perivascular, Edema | 1 |
Perivascular, Infiltration Cellular, | |
Eosinophil | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 1 1 |
Glands, Dilatation | 1 1 2 1 1 2 1 1 2 1 1 1 1 2 2 1 2 2 1 1 2 2 2 1|
Goblet Cell, Hyperplasia | 1 1 3 1 1 3 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Nasopharyngeal Duct, Cyst | 4 |
Nasopharyngeal Duct, Foreign Body | 1 |
Nasopharyngeal Duct, Respiratory | |
Epithelium, Hyperplasia | 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | |
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|
| 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Olfactory Epithelium, Degeneration | 2 2 3 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Olfactory Epithelium, Hyperplasia, | |
Basal Cell | 2 2 3 1 2 2 1 1 2 2 2 1 2 2 2 2 1 2 2 2 2 1 2 2|
Olfactory Epithelium, Metaplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Mineralization | 1 |
Lens, Cataract | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 1 2 2 1 2 2 1 1 2 1 1 2 1 2 2 2 3 1 4 2 4 1 1|
Cortex, Renal Tubule, Degeneration | 2 |
Cortex, Renal Tubule, Hyperplasia | 4 |
Papilla, Renal Tubule, Dilatation | |
Pelvis, Transitional Epithelium, | |
Mineralization | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 3 2 1 |
__________________________________________|__________________________________________________________________________
Page 94
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Clear Cell Focus | | 1 4.0|
Hepatodiaphragmatic Nodule | 4 4 4 4 4 | 8 4.0|
Necrosis | 4 | 2 3.5|
Vacuolization Cytoplasmic | 3 2 | 3 2.3|
Serosa, Fibrosis | 4 | 1 4.0|
Serosa, Hemorrhage | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 11 |
Necrosis | 3 4 3 2 3 3 | 9 3.0|
Fat, Hemorrhage | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 4 |
Gingival, Cyst | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 2 1 1 2 2| 21 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Erosion | | 2 2.5|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 3 | 14 2.3|
Bilateral, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + M + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 3 | 8 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 2 2 | 7 2.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2| 2 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 3 4 3 3 | 9 3.4|
Interstitial Cell, Hyperplasia | | 3 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Deep Cervical, Angiectasis | 2 | 1 2.0|
Pancreatic, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M + M + M M M + M M M M M M M M M M M M M| 5 |
Hemorrhage | | 1 3.0|
Infiltration Cellular | | 1 3.0|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | | 3 3.3|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + M M + M M M + + + M + M M +| 38 |
Angiectasis | | 1 4.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + M M M + + + M + M + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Galactocele | 4 | 3 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X 4 | 2 4.0|
Inflammation, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 4 4| 6 3.5|
Gliosis | 3 | 1 3.0|
Hemorrhage | 3| 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Foreign Body | 2 | 2 2.5|
Inflammation, Suppurative | 1 | 1 1.0|
Epiglottis, Metaplasia, Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage | 3 1 | 4 1.5|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 2 | 14 1.1|
Alveolar Epithelium, Hyperplasia | 3 4 3 | 6 3.2|
Alveolar Epithelium, Hypertrophy | 1 | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolus, Hypertrophy | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 | 4 1.5|
Interstitium, Fibrosis | | 1 1.0|
Perivascular, Edema | | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Eosinophil | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 1 2 2 1 | 10 1.6|
Glands, Dilatation | 1 2 2 2 1 1 1 1 2 2 2 2 2 1 2 2 1 2 1 1 2 2| 46 1.5|
Goblet Cell, Hyperplasia | 1 1 1 2 2 1 | 16 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 3| 4 2.3|
Nasopharyngeal Duct, Cyst | | 1 4.0|
Nasopharyngeal Duct, Foreign Body | | 1 1.0|
Nasopharyngeal Duct, Respiratory | | |
Epithelium, Hyperplasia | | 1 4.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 | 1 2.0|
Olfactory Epithelium, Degeneration | 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 49 2.0|
Olfactory Epithelium, Hyperplasia, | | |
Basal Cell | 2 2 2 1 1 2 1 1 2 2 2 2 2 2 2 2 1 2 1 1 1 2 2 2| 48 1.7|
Olfactory Epithelium, Metaplasia | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Glands, Degeneration, Cystic | 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Cornea, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 88004-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:44:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1| |
| 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
400 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Lens, Cataract | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Cyst | 4 | 1 4.0|
Nephropathy, Chronic | 2 1 4 3 4 1 1 1 1 1 2 2 2 1 2 1 2 3 1 3 3| 45 1.8|
Cortex, Renal Tubule, Degeneration | | 1 2.0|
Cortex, Renal Tubule, Hyperplasia | 4 | 2 4.0|
Papilla, Renal Tubule, Dilatation | 4 | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Mineralization | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Calculus Micro Observation Only | 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------