TDMS Study 97013-05 Pathology Tables
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/L
Include 004 175 MG/L
Include 006 350 MG/L
Include 008 700 MG/L
Include 001 0 MG/L
Include 003 175 MG/L
Include 005 350 MG/L
Include 007 700 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 4 2 1 1
Moribund Sacrifice 1 3 1
Survivors
Terminal Sacrifice 10 13 11 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 [2.0]
Liver (15) (15) (15) (15)
Basophilic Focus 1
Hematopoietic Cell Proliferation 1 [1.0] 1 [2.0] 3 [1.0] 1 [1.0]
Inflammation 11 [1.1] 11 [1.0] 13 [1.3] 14 [1.5]
Mitotic Alteration 1 [2.0]
Necrosis 2 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 4 [1.0] 8 [1.1] 10 [1.5]
Hepatocyte, Hypertrophy 1 [2.0] 2 [2.5] 8 [2.4] 12 [2.8]
Hepatocyte, Vacuolization Cytoplasmic 2 [1.5] 5 [1.2] 4 [1.5] 8 [1.6]
Salivary Glands (1) (1)
Inflammation 1 [4.0]
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0]
Hypertrophy 1 [1.0]
Subcapsular, Hyperplasia 8 [1.0] 8 [1.0] 7 [1.0] 10 [1.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 1 [1.0] 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 1 [1.0]
Thyroid Gland (15) (14) (15) (15)
Cyst 1 [1.0] 1 [1.0] 2 [1.5] 1 [2.0]
Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 [1.0] 1 [1.0]
Oviduct (1)
Inflammation, Suppurative 1 [2.0]
Uterus (15) (15) (15) (15)
Hydrometra 1 [1.0]
Inflammation, Suppurative 1 [2.0]
Endometrium, Hyperplasia, Cystic 9 [1.3] 8 [1.0] 9 [1.2] 8 [1.1]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia 1 [1.0] 1 [3.0]
Infiltration Cellular, Plasma Cell 1 [1.0] 1 [1.0]
Infiltration Cellular, Polymorphonuclear 1 [1.0] 1 [2.0]
Spleen (15) (15) (15) (15)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 2 [1.5] 3 [1.7] 3 [1.3] 1 [2.0]
Lymphoid Follicle, Atrophy 1 [3.0] 1 [4.0]
Red Pulp, Atrophy 1 [1.0]
Thymus (14) (15) (15) (14)
Atrophy 2 [3.0] 1 [3.0] 1 [3.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (6) (3)
Epidermis, Hyperplasia, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Infiltration Cellular, Histiocyte 1 [1.0]
Inflammation 1 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 [1.0] 3 [1.0] 2 [1.0]
Cyst 2 [1.5] 3 [1.0] 1 [1.0] 2 [1.5]
Inflammation 1 [3.0]
Nephropathy 1 [1.0] 1 [1.0] 4 [1.0]
Renal Tubule, Hypertrophy 1 [1.0] 2 [1.0] 5 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 3 3 1
Survivors
Terminal Sacrifice 13 12 12 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 [2.0]
Intestine Small, Duodenum (15) (15) (15) (15)
Erosion 1 [2.0]
Liver (15) (15) (15) (15)
Cyst 1 [1.0]
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0]
Inflammation 7 [1.0] 6 [1.0] 7 [1.1] 5 [1.0]
Necrosis 3 [1.0] 1 [1.0] 3 [1.0] 3 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.0] 4 [1.0] 3 [1.0] 3 [1.0]
Salivary Glands (1) (2) (1)
Inflammation 1 [1.0]
Inflammation, Chronic Active 1 [4.0]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 1 [1.0]
Hypertrophy 6 [1.0] 7 [1.1] 7 [1.1] 9 [1.0]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 1 [1.0]
Inflammation, Suppurative 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 [2.0]
Thyroid Gland (15) (15) (15) (15)
Cyst 2 [1.5] 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Inflammation 1 [1.0]
Preputial Gland (3) (1)
Inflammation 2 [1.5] 1 [1.0]
Duct, Ectasia 3 [2.0] 1 [1.0]
Testes (15) (15) (15) (15)
Hypoplasia 1 [4.0]
Germinal Epithelium, Degeneration 3 [2.0] 2 [2.0] 3 [2.0] 3 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (14) (13)
Hyperplasia 1 [3.0]
Infiltration Cellular, Plasma Cell 1 [1.0] 1 [2.0]
Inflammation 1 [2.0]
Necrosis 1 [1.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 4 [1.0] 2 [1.5]
Lymphoid Follicle, Atrophy 1 [1.0] 1 [2.0]
Thymus (15) (14) (15) (15)
Atrophy 1 [2.0] 1 [2.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (2) (2) (1)
Epidermis, Hyperplasia, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 1 [1.0] 1 [1.0] 1 [2.0]
Thrombosis 1 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [1.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Retina, Degeneration 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 1 [1.0] 2 [1.0] 1 [1.0] 1 [1.0]
Cyst 2 [1.0] 3 [1.3]
Mineralization 2 [1.5]
Nephropathy 4 [1.0] 3 [1.3] 4 [1.3] 11 [1.3]
Renal Tubule, Degeneration 4 [1.0] 4 [1.0] 9 [1.3]
Renal Tubule, Dilatation 4 [1.0] 11 [1.2] 14 [1.6] 15 [1.7]
Renal Tubule, Hypertrophy 1 [1.0] 3 [1.0] 6 [1.2] 11 [1.0]
Renal Tubule, Necrosis 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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