TDMS Study 96017-06 Pathology Tables
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 FINAL#1 MICE Facility: Southern Research Institute Chemical CAS #: 631-64-1 Lock Date: 11/15/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 10 13 13 11 Moribund Sacrifice 2 2 5 7 Survivors Terminal Sacrifice 38 35 31 32 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (49) (49) (48) (49) Ulcer 1 [4.0] Intestine Large, Cecum (47) (46) (49) (46) Edema 2 [2.0] 1 [2.0] 3 [2.0] Inflammation, Chronic 1 [3.0] 1 [2.0] Epithelium, Hyperplasia 1 [3.0] Intestine Small, Duodenum (46) (48) (48) (45) Epithelium, Hyperplasia 1 [3.0] Intestine Small, Jejunum (46) (47) (49) (43) Hyperplasia, Lymphoid 2 [3.0] 2 [3.5] Intestine Small, Ileum (45) (47) (47) (46) Inflammation, Chronic 1 [3.0] Liver (49) (50) (50) (49) Angiectasis 1 [4.0] 2 [3.0] Basophilic Focus 1 3 3 Clear Cell Focus 3 1 8 5 Eosinophilic Focus 7 6 10 9 Hematopoietic Cell Proliferation 2 [2.5] 4 [2.5] 2 [3.0] 2 [2.5] Hepatodiaphragmatic Nodule 2 Hyperplasia, Lymphoid 2 [3.5] 1 [2.0] Infarct 1 [3.0] Infiltration Cellular, Mixed Cell 7 [2.1] 7 [2.6] 4 [2.3] 9 [2.4] Inflammation, Chronic Active 1 [1.0] Mixed Cell Focus 2 6 3 1 Necrosis, Focal 3 [1.7] 2 [3.0] 3 [2.3] 2 [3.5] Tension Lipidosis 1 3 Centrilobular, Necrosis 1 [3.0] 4 [2.8] 4 [2.3] Hepatocyte, Vacuolization Cytoplasmic 2 [3.5] 7 [3.1] 4 [3.3] 2 [3.5] Kupffer Cell, Pigmentation 3 [2.3] 3 [2.3] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Mesentery (28) (20) (16) (19) Fat, Necrosis 22 [3.3] 18 [3.4] 11 [3.5] 13 [2.8] Pancreas (49) (49) (49) (47) Atrophy 1 [3.0] 1 [3.0] 3 [2.7] Cyst 1 [3.0] 3 [3.0] Inflammation, Chronic 1 [3.0] Acinus, Cytoplasmic Alteration 1 [3.0] Salivary Glands (50) (49) (50) (50) Hyperplasia, Lymphoid 15 [2.7] 13 [2.2] 16 [2.2] 10 [2.5] Stomach, Forestomach (49) (50) (50) (49) Erosion 1 [2.0] Inflammation, Chronic 1 [3.0] 2 [2.0] 2 [1.5] 1 [2.0] Ulcer 1 [2.0] 1 [2.0] 1 [2.0] 3 [2.3] Epithelium, Hyperplasia 4 [1.5] 5 [2.6] 4 [2.0] Stomach, Glandular (49) (50) (50) (49) Erosion 1 [3.0] 1 [3.0] Pylorus, Epithelium, Hyperplasia, Atypical 1 [4.0] Tooth (1) Malformation 1 ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (1) (1) Hypertrophy 1 [4.0] Inflammation, Chronic Active 1 [4.0] Heart (50) (49) (50) (50) Cardiomyopathy 1 [1.0] 1 [2.0] Inflammation, Chronic 1 [3.0] 1 [3.0] Inflammation, Chronic Active 1 [3.0] Mineralization 1 [3.0] 1 [3.0] 2 [2.5] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (49) Accessory Adrenal Cortical Nodule 9 [3.0] 11 [3.0] 6 [3.0] 9 [3.0] Hyperplasia, Focal 2 [2.5] 1 [3.0] Hypertrophy, Focal 1 [2.0] Capsule, Hyperplasia 1 [3.0] 1 [2.0] Adrenal Medulla (50) (50) (50) (49) Hyperplasia 2 [1.0] 1 [2.0] 1 [1.0] Islets, Pancreatic (49) (49) (49) (46) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hyperplasia 2 [2.0] 5 [2.0] 3 [1.7] 3 [2.0] Parathyroid Gland (45) (49) (47) (49) Cyst 2 [3.0] 1 [3.0] 1 [3.0] 3 [3.0] Pituitary Gland (47) (49) (49) (49) Pars Distalis, Angiectasis 2 [2.5] 3 [2.0] 1 [2.0] 1 [2.0] Pars Distalis, Cyst 2 [3.0] 2 [3.0] 1 [3.0] 1 [3.0] Pars Distalis, Hyperplasia, Focal 4 [2.5] 9 [2.2] 4 [1.8] 7 [1.9] Pars Intermedia, Hyperplasia, Focal 1 [3.0] Thyroid Gland (50) (50) (50) (50) Degeneration, Cystic 10 [1.7] 26 [1.9] 16 [1.8] 14 [1.9] Follicular Cell, Hyperplasia 8 [1.1] 1 [1.0] 1 [2.0] 2 [1.5] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (48) (48) (49) Cyst 1 [3.0] Ovary (49) (47) (47) (49) Angiectasis 5 [2.8] 3 [2.7] 9 [2.4] 7 [2.6] Cyst 14 [3.1] 12 [2.8] 14 [3.0] 22 [3.0] Corpus Luteum, Hyperplasia 1 [3.0] 1 [3.0] Granulosa Cell, Hyperplasia 1 [2.0] Interstitial Cell, Hyperplasia 1 [3.0] Uterus (50) (50) (50) (50) Angiectasis 4 [3.0] 1 [2.0] 2 [2.0] Hyperplasia, Cystic 44 [3.3] 42 [3.4] 44 [3.0] 39 [3.0] Inflammation, Chronic 1 [2.0] 1 [2.0] 1 [3.0] Metaplasia, Squamous 1 [3.0] 1 [3.0] 1 [3.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hyperplasia 20 [2.9] 26 [2.9] 24 [2.9] 20 [3.0] Infiltration Cellular, Mast Cell 1 [3.0] Lymph Node (12) (13) (11) (8) Hyperplasia, Lymphoid 1 [2.0] Bronchial, Hemorrhage 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Bronchial, Hyperplasia, Lymphoid 1 [2.0] Deep Cervical, Hemorrhage 1 [4.0] Iliac, Hematopoietic Cell Proliferation 1 [3.0] Iliac, Hemorrhage 1 [3.0] 1 [4.0] Iliac, Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] 1 [3.0] 2 [2.0] Iliac, Pigmentation 1 [3.0] Inguinal, Hematopoietic Cell Proliferation 1 [3.0] Inguinal, Hyperplasia, Lymphoid 2 [2.5] Mediastinal, Hemorrhage 1 [2.0] Mediastinal, Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] 1 [2.0] 1 [3.0] Mediastinal, Pigmentation 1 [2.0] Pancreatic, Hyperplasia, Lymphoid 1 [2.0] Renal, Hyperplasia, Lymphoid 1 [2.0] 1 [3.0] 1 [2.0] Lymph Node, Mandibular (48) (49) (47) (50) Atrophy 1 [2.0] 1 [3.0] 1 [3.0] Hematopoietic Cell Proliferation 1 [1.0] 1 [2.0] 2 [2.5] Hemorrhage 2 [1.5] 2 [2.0] 1 [2.0] Hyperplasia, Lymphoid 13 [2.3] 6 [2.3] 8 [2.8] 9 [2.8] Pigmentation 18 [2.2] 25 [2.2] 17 [2.1] 23 [2.3] Lymph Node, Mesenteric (49) (49) (48) (45) Angiectasis 1 [2.0] Atrophy 2 [2.5] 1 [3.0] Ectasia 1 [4.0] Hematopoietic Cell Proliferation 2 [1.5] 2 [2.0] 1 [2.0] Hemorrhage 1 [4.0] 1 [3.0] 1 [1.0] 5 [2.4] Hyperplasia, Lymphoid 8 [2.3] 9 [2.4] 7 [2.4] 5 [2.2] Pigmentation 1 [3.0] 1 [3.0] Spleen (50) (50) (50) (48) Hematopoietic Cell Proliferation 34 [2.2] 42 [2.5] 35 [2.5] 34 [2.5] Necrosis 1 [4.0] Pigmentation 5 [2.8] 5 [3.0] 1 [3.0] 2 [3.0] Lymphoid Follicle, Atrophy 1 [2.0] 2 [3.0] 2 [2.5] Lymphoid Follicle, Hyperplasia 8 [2.5] 11 [2.8] 14 [2.5] 12 [2.5] Thymus (44) (47) (47) (48) Atrophy 8 [3.0] 9 [3.0] 11 [2.8] 13 [2.8] Hemorrhage 1 [3.0] Hyperplasia, Lymphoid 3 [2.7] 3 [2.0] 2 [3.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Hyperplasia 5 [1.8] 6 [2.0] 2 [2.5] 5 [2.2] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Skin (50) (50) (50) (50) Edema 1 [2.0] 1 [4.0] 1 [3.0] Erosion 1 [3.0] Ulcer 2 [2.0] 1 [4.0] 1 [1.0] 1 [4.0] Epidermis, Hyperplasia 2 [3.5] 1 [3.0] 2 [1.5] 1 [4.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Myelofibrosis 1 [2.0] 2 [2.5] 1 [2.0] 2 [2.5] Skeletal Muscle (3) (4) (2) (5) Inflammation, Chronic Active 1 [3.0] ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (50) (50) Compression 1 [3.0] 1 [3.0] 1 [2.0] Hemorrhage 2 [2.5] Necrosis 1 [2.0] 1 [2.0] Peripheral Nerve (1) (1) (1) Atrophy 1 [3.0] Spinal Cord (1) (1) (1) Necrosis 1 [3.0] ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Congestion 2 [3.0] Hemorrhage 2 [2.5] 2 [2.0] 3 [2.0] Hyperplasia, Lymphoid 5 [2.0] 5 [2.2] 1 [2.0] 3 [2.3] Infiltration Cellular, Histiocyte 1 [3.0] 2 [2.0] 2 [3.5] 4 [1.8] Alveolar Epithelium, Hyperplasia 3 [1.7] 3 [2.0] 4 [2.0] Perivascular, Inflammation, Chronic Active 1 [3.0] Nose (50) (50) (50) (50) Inflammation, Chronic 1 [2.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Atrophy 1 [4.0] Cataract 2 [1.5] 2 [1.5] Inflammation, Chronic 2 [1.5] 2 [2.5] 3 [2.3] 3 [1.3] Cornea, Hyperplasia 1 [2.0] 4 [2.3] Cornea, Mineralization 1 [2.0] Harderian Gland (49) (50) (50) (50) Hyperplasia, Focal 2 [3.0] 4 [2.8] 4 [2.0] 2 [2.0] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (49) Cyst 1 [3.0] 1 [3.0] Hydronephrosis 1 [3.0] 1 [2.0] Hyperplasia, Lymphoid 7 [2.3] 2 [2.5] 5 [2.2] 8 [2.4] Infarct 3 [1.7] 8 [1.8] 6 [1.8] 8 [2.5] Nephropathy 14 [1.6] 8 [1.4] 15 [1.7] 12 [1.2] Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0] 1 [3.0] 2 [3.0] 2 [3.0] Renal Tubule, Dilatation 2 [2.5] 1 [2.0] 1 [2.0] Renal Tubule, Necrosis 1 [1.0] 1 [2.0] Renal Tubule, Pigmentation 1 [4.0] 3 [2.3] 1 [3.0] Urinary Bladder (50) (49) (50) (49) Edema 2 [3.0] Hyperplasia, Lymphoid 3 [3.0] 5 [2.2] 3 [2.0] 2 [2.5] Transitional Epithelium, Hyperplasia 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 4 6 3 6 Natural Death 14 6 13 13 Survivors Terminal Sacrifice 31 38 34 31 Other 1 Animals Examined Microscopically 49 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (43) (49) (48) (46) Edema 2 [2.0] 2 [2.5] 3 [2.0] 1 [2.0] Hyperplasia, Lymphoid 1 [3.0] Intestine Small, Duodenum (42) (50) (46) (48) Hyperplasia, Lymphoid 1 [2.0] Intestine Small, Jejunum (44) (49) (46) (45) Hyperplasia, Lymphoid 2 [2.0] 2 [3.0] Liver (49) (50) (50) (50) Angiectasis 1 [3.0] Basophilic Focus 2 1 2 Clear Cell Focus 10 13 23 13 Congestion 1 [3.0] Cyst 1 [3.0] 1 [3.0] Eosinophilic Focus 15 10 15 17 Hematopoietic Cell Proliferation 1 [2.0] Hemorrhage 1 [3.0] Hepatodiaphragmatic Nodule 1 Infarct 1 [4.0] 1 [4.0] Infiltration Cellular, Mixed Cell 2 [2.5] 4 [2.5] 2 [2.5] 2 [2.0] Mixed Cell Focus 3 7 8 4 Necrosis, Focal 8 [2.9] 7 [2.7] 3 [2.0] 5 [2.6] Tension Lipidosis 1 1 2 Bile Duct, Cyst 1 [1.0] Bile Duct, Cyst Multilocular 1 Centrilobular, Necrosis 4 [3.0] 4 [2.3] 5 [2.8] Hepatocyte, Vacuolization Cytoplasmic 8 [2.8] 9 [3.1] 4 [3.3] 10 [3.0] Kupffer Cell, Pigmentation 1 [3.0] 1 [2.0] 1 [3.0] 1 [2.0] Mesentery (7) (7) (10) (7) Inflammation, Chronic 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 8 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Fat, Necrosis 5 [3.4] 6 [2.8] 7 [3.1] 4 [2.8] Pancreas (46) (50) (50) (49) Necrosis 1 [4.0] Acinus, Cytoplasmic Alteration 2 [3.0] 2 [3.0] 2 [3.0] Salivary Glands (49) (50) (50) (50) Atrophy 1 [2.0] 2 [2.0] Hyperplasia, Lymphoid 3 [2.0] 4 [2.0] 6 [2.5] 1 [2.0] Stomach, Forestomach (49) (50) (50) (50) Diverticulum 2 1 Erosion 1 [2.0] 1 [2.0] 2 [1.5] Inflammation, Chronic 3 [2.0] 1 [3.0] 3 [2.3] 6 [2.5] Ulcer 2 [1.0] 2 [2.5] 2 [2.5] 2 [2.0] Epithelium, Hyperplasia 4 [2.3] 3 [3.0] 4 [2.8] 7 [2.4] Epithelium, Hyperplasia, Focal 1 [3.0] 1 [3.0] Stomach, Glandular (47) (50) (50) (50) Erosion 2 [3.0] 2 [2.0] 1 [3.0] Glands, Hyperplasia 1 [2.0] Tooth (5) (6) Malformation 5 6 ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) (50) (50) Cardiomyopathy 1 [2.0] 1 [1.0] Inflammation, Chronic 1 [2.0] Mineralization 3 [2.3] 2 [2.0] 1 [2.0] Myocardium, Necrosis 1 [3.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Accessory Adrenal Cortical Nodule 7 [3.0] 5 [3.0] 4 [3.0] 6 [3.0] Hyperplasia, Focal 4 [1.8] 7 [2.3] 5 [1.8] 1 [2.0] Hypertrophy 1 [3.0] 1 [2.0] Hypertrophy, Focal 12 [1.8] 11 [1.5] 13 [1.8] 6 [1.7] Capsule, Hyperplasia 7 [2.3] 4 [2.8] 1 [2.0] 5 [2.4] Adrenal Medulla (49) (50) (50) (50) Hyperplasia 1 [2.0] 1 [1.0] 1 [1.0] Islets, Pancreatic (46) (50) (50) (49) Atrophy 1 [4.0] Hyperplasia 34 [2.2] 32 [2.4] 26 [2.3] 13 [1.8] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 9 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Parathyroid Gland (45) (47) (49) (47) Cyst 2 [2.5] 3 [3.0] 4 [3.0] Pituitary Gland (45) (50) (48) (48) Pars Distalis, Cyst 7 [3.0] 7 [3.0] 7 [3.0] 5 [3.0] Pars Distalis, Hyperplasia, Focal 1 [3.0] 1 [1.0] Thyroid Gland (48) (50) (50) (50) Degeneration, Cystic 5 [2.0] 8 [1.6] 3 [1.7] 6 [1.8] Follicular Cell, Hyperplasia 3 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (49) (50) (50) (50) Atypia Cellular 5 [2.4] 4 [2.5] 2 [2.0] 6 [2.3] Granuloma Sperm 1 [4.0] 2 [3.5] 2 [3.5] 2 [2.5] Spermatocele 1 [3.0] 1 [3.0] Preputial Gland (49) (50) (50) (50) Cyst 25 [2.9] 26 [3.0] 33 [3.0] 33 [3.0] Inflammation, Chronic 21 [2.1] 30 [2.3] 24 [2.3] 28 [2.2] Prostate (48) (50) (50) (49) Inflammation, Chronic 4 [2.8] 1 [3.0] Seminal Vesicle (49) (50) (50) (50) Degeneration 3 [3.0] 5 [3.0] 1 [3.0] Inflammation, Chronic 1 [3.0] Testes (49) (50) (50) (50) Germinal Epithelium, Atrophy 9 [2.1] 4 [2.0] 4 [1.5] 8 [1.9] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (47) (50) (50) (50) Angiectasis 1 [2.0] Depletion Cellular 1 [2.0] Hyperplasia 22 [2.5] 22 [2.7] 28 [2.7] 32 [2.6] Lymph Node (1) (2) (5) (1) Bronchial, Hyperplasia, Lymphoid 1 [3.0] Iliac, Ectasia 1 [2.0] Inguinal, Hyperplasia, Lymphoid 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 10 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Inguinal, Pigmentation 1 [3.0] Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] Mediastinal, Pigmentation 1 [3.0] Pancreatic, Hyperplasia, Lymphoid 1 [3.0] Lymph Node, Mandibular (48) (50) (48) (48) Atrophy 5 [2.4] 2 [2.5] 3 [2.0] 7 [2.1] Hematopoietic Cell Proliferation 1 [2.0] Hemorrhage 1 [2.0] 1 [2.0] Hyperplasia, Lymphoid 15 [2.5] 14 [2.2] 6 [2.5] 7 [2.3] Pigmentation 7 [2.1] 8 [2.0] 1 [2.0] 7 [2.1] Lymph Node, Mesenteric (46) (49) (49) (47) Atrophy 4 [2.5] 2 [2.5] 1 [2.0] 9 [2.3] Hematopoietic Cell Proliferation 1 [2.0] 1 [1.0] 3 [1.7] 3 [2.0] Hemorrhage 8 [1.9] 5 [2.0] 9 [1.7] 7 [2.0] Hyperplasia, Lymphoid 2 [2.5] 8 [2.5] 3 [2.7] 6 [2.5] Hyperplasia, Plasma Cell 1 [3.0] Spleen (47) (50) (50) (50) Angiectasis 1 [2.0] Hematopoietic Cell Proliferation 18 [3.1] 20 [2.6] 28 [2.8] 38 [2.9] Pigmentation 1 [2.0] 1 [3.0] 1 [2.0] Lymphoid Follicle, Atrophy 4 [2.5] 7 [2.7] 3 [2.7] 8 [2.8] Lymphoid Follicle, Hyperplasia 3 [2.3] 6 [2.5] 6 [2.7] 6 [2.3] Thymus (42) (45) (46) (47) Atrophy 14 [3.1] 16 [2.9] 12 [2.8] 22 [3.0] Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 1 [4.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (49) (50) (50) (50) Cyst Epithelial Inclusion 2 [3.0] Ulcer 3 [4.0] 2 [4.0] 3 [4.0] Epidermis, Hyperplasia 3 [2.0] 2 [2.5] 3 [3.3] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (49) (50) (50) (50) Hyperostosis 1 [2.0] Cranium, Hyperostosis 1 [3.0] 1 [3.0] Skeletal Muscle (1) (1) (1) Atrophy 1 [1.0] ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 11 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Peripheral Nerve (2) (2) (1) Atrophy 1 [1.0] 1 [3.0] Spinal Cord (2) (2) (1) Gliosis 1 [3.0] ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Edema 2 [2.0] 1 [3.0] 2 [2.0] Hemorrhage 2 [2.5] 4 [1.5] Hyperplasia, Lymphoid 3 [2.7] 1 [2.0] Infiltration Cellular, Histiocyte 2 [1.0] 6 [2.3] 3 [2.3] 6 [3.2] Metaplasia, Osseous 1 [1.0] 2 [1.0] 1 [1.0] Alveolar Epithelium, Hyperplasia 2 [1.5] 6 [1.7] 6 [2.3] 7 [1.9] Bronchiole, Hyperplasia 1 [1.0] Nose (48) (50) (50) (50) Foreign Body 1 Inflammation, Chronic 1 [2.0] 1 [3.0] 3 [2.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (49) (50) (50) (50) Atrophy 1 [4.0] Cataract 1 [2.0] 1 [1.0] 5 [1.4] Inflammation, Chronic 2 [1.5] 2 [2.0] Bilateral, Cataract 1 [3.0] Cornea, Hyperplasia 1 [2.0] 1 [2.0] Harderian Gland (49) (50) (50) (50) Cyst 1 [3.0] Hyperplasia, Focal 5 [2.6] 1 [4.0] 1 [3.0] 1 [3.0] Lacrimal Gland (1) Cyst 1 [3.0] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Cyst 9 [3.0] 13 [3.0] 14 [3.0] 11 [3.0] Hydronephrosis 4 [2.0] 2 [2.5] 4 [2.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 12 NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000 MG/L ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Hyperplasia, Lymphoid 5 [2.6] 5 [2.0] 6 [2.3] 5 [2.4] Infarct 3 [1.7] 7 [2.3] 4 [2.0] 5 [1.8] Inflammation, Suppurative 1 [3.0] 1 [4.0] Metaplasia, Osseous 6 [2.2] 3 [2.3] 2 [2.0] 2 [3.0] Nephropathy 36 [1.8] 44 [1.5] 42 [1.7] 39 [1.8] Papilla, Necrosis 1 [3.0] Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0] Renal Tubule, Dilatation 1 [3.0] 3 [2.3] 1 [3.0] Renal Tubule, Hyperplasia 1 [2.0] 1 [1.0] 1 [1.0] 3 [1.7] Renal Tubule, Necrosis 1 [2.0] Renal Tubule, Pigmentation 1 [4.0] 3 [2.7] 2 [2.5] 7 [3.0] Transitional Epithelium, Hyperplasia 1 [2.0] Urethra (3) Angiectasis 3 [4.0] Inflammation, Chronic Active 3 [2.7] Urinary Bladder (49) (50) (50) (49) Edema 1 [3.0] Hemorrhage 1 [2.0] Hyperplasia, Lymphoid 1 [2.0] 1 [3.0] Inflammation, Chronic 1 [2.0] Transitional Epithelium, Hyperplasia 1 [1.0] 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------