TDMS Study 96017-06 Pathology Tables
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 10 13 13 11
Moribund Sacrifice 2 2 5 7
Survivors
Terminal Sacrifice 38 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (49) (48) (49)
Ulcer 1 [4.0]
Intestine Large, Cecum (47) (46) (49) (46)
Edema 2 [2.0] 1 [2.0] 3 [2.0]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Epithelium, Hyperplasia 1 [3.0]
Intestine Small, Duodenum (46) (48) (48) (45)
Epithelium, Hyperplasia 1 [3.0]
Intestine Small, Jejunum (46) (47) (49) (43)
Hyperplasia, Lymphoid 2 [3.0] 2 [3.5]
Intestine Small, Ileum (45) (47) (47) (46)
Inflammation, Chronic 1 [3.0]
Liver (49) (50) (50) (49)
Angiectasis 1 [4.0] 2 [3.0]
Basophilic Focus 1 3 3
Clear Cell Focus 3 1 8 5
Eosinophilic Focus 7 6 10 9
Hematopoietic Cell Proliferation 2 [2.5] 4 [2.5] 2 [3.0] 2 [2.5]
Hepatodiaphragmatic Nodule 2
Hyperplasia, Lymphoid 2 [3.5] 1 [2.0]
Infarct 1 [3.0]
Infiltration Cellular, Mixed Cell 7 [2.1] 7 [2.6] 4 [2.3] 9 [2.4]
Inflammation, Chronic Active 1 [1.0]
Mixed Cell Focus 2 6 3 1
Necrosis, Focal 3 [1.7] 2 [3.0] 3 [2.3] 2 [3.5]
Tension Lipidosis 1 3
Centrilobular, Necrosis 1 [3.0] 4 [2.8] 4 [2.3]
Hepatocyte, Vacuolization Cytoplasmic 2 [3.5] 7 [3.1] 4 [3.3] 2 [3.5]
Kupffer Cell, Pigmentation 3 [2.3] 3 [2.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (28) (20) (16) (19)
Fat, Necrosis 22 [3.3] 18 [3.4] 11 [3.5] 13 [2.8]
Pancreas (49) (49) (49) (47)
Atrophy 1 [3.0] 1 [3.0] 3 [2.7]
Cyst 1 [3.0] 3 [3.0]
Inflammation, Chronic 1 [3.0]
Acinus, Cytoplasmic Alteration 1 [3.0]
Salivary Glands (50) (49) (50) (50)
Hyperplasia, Lymphoid 15 [2.7] 13 [2.2] 16 [2.2] 10 [2.5]
Stomach, Forestomach (49) (50) (50) (49)
Erosion 1 [2.0]
Inflammation, Chronic 1 [3.0] 2 [2.0] 2 [1.5] 1 [2.0]
Ulcer 1 [2.0] 1 [2.0] 1 [2.0] 3 [2.3]
Epithelium, Hyperplasia 4 [1.5] 5 [2.6] 4 [2.0]
Stomach, Glandular (49) (50) (50) (49)
Erosion 1 [3.0] 1 [3.0]
Pylorus, Epithelium, Hyperplasia, Atypical 1 [4.0]
Tooth (1)
Malformation 1
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Hypertrophy 1 [4.0]
Inflammation, Chronic Active 1 [4.0]
Heart (50) (49) (50) (50)
Cardiomyopathy 1 [1.0] 1 [2.0]
Inflammation, Chronic 1 [3.0] 1 [3.0]
Inflammation, Chronic Active 1 [3.0]
Mineralization 1 [3.0] 1 [3.0] 2 [2.5]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 9 [3.0] 11 [3.0] 6 [3.0] 9 [3.0]
Hyperplasia, Focal 2 [2.5] 1 [3.0]
Hypertrophy, Focal 1 [2.0]
Capsule, Hyperplasia 1 [3.0] 1 [2.0]
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 2 [1.0] 1 [2.0] 1 [1.0]
Islets, Pancreatic (49) (49) (49) (46)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 2 [2.0] 5 [2.0] 3 [1.7] 3 [2.0]
Parathyroid Gland (45) (49) (47) (49)
Cyst 2 [3.0] 1 [3.0] 1 [3.0] 3 [3.0]
Pituitary Gland (47) (49) (49) (49)
Pars Distalis, Angiectasis 2 [2.5] 3 [2.0] 1 [2.0] 1 [2.0]
Pars Distalis, Cyst 2 [3.0] 2 [3.0] 1 [3.0] 1 [3.0]
Pars Distalis, Hyperplasia, Focal 4 [2.5] 9 [2.2] 4 [1.8] 7 [1.9]
Pars Intermedia, Hyperplasia, Focal 1 [3.0]
Thyroid Gland (50) (50) (50) (50)
Degeneration, Cystic 10 [1.7] 26 [1.9] 16 [1.8] 14 [1.9]
Follicular Cell, Hyperplasia 8 [1.1] 1 [1.0] 1 [2.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (48) (49)
Cyst 1 [3.0]
Ovary (49) (47) (47) (49)
Angiectasis 5 [2.8] 3 [2.7] 9 [2.4] 7 [2.6]
Cyst 14 [3.1] 12 [2.8] 14 [3.0] 22 [3.0]
Corpus Luteum, Hyperplasia 1 [3.0] 1 [3.0]
Granulosa Cell, Hyperplasia 1 [2.0]
Interstitial Cell, Hyperplasia 1 [3.0]
Uterus (50) (50) (50) (50)
Angiectasis 4 [3.0] 1 [2.0] 2 [2.0]
Hyperplasia, Cystic 44 [3.3] 42 [3.4] 44 [3.0] 39 [3.0]
Inflammation, Chronic 1 [2.0] 1 [2.0] 1 [3.0]
Metaplasia, Squamous 1 [3.0] 1 [3.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 20 [2.9] 26 [2.9] 24 [2.9] 20 [3.0]
Infiltration Cellular, Mast Cell 1 [3.0]
Lymph Node (12) (13) (11) (8)
Hyperplasia, Lymphoid 1 [2.0]
Bronchial, Hemorrhage 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bronchial, Hyperplasia, Lymphoid 1 [2.0]
Deep Cervical, Hemorrhage 1 [4.0]
Iliac, Hematopoietic Cell Proliferation 1 [3.0]
Iliac, Hemorrhage 1 [3.0] 1 [4.0]
Iliac, Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] 1 [3.0] 2 [2.0]
Iliac, Pigmentation 1 [3.0]
Inguinal, Hematopoietic Cell Proliferation 1 [3.0]
Inguinal, Hyperplasia, Lymphoid 2 [2.5]
Mediastinal, Hemorrhage 1 [2.0]
Mediastinal, Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] 1 [2.0] 1 [3.0]
Mediastinal, Pigmentation 1 [2.0]
Pancreatic, Hyperplasia, Lymphoid 1 [2.0]
Renal, Hyperplasia, Lymphoid 1 [2.0] 1 [3.0] 1 [2.0]
Lymph Node, Mandibular (48) (49) (47) (50)
Atrophy 1 [2.0] 1 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0] 1 [2.0] 2 [2.5]
Hemorrhage 2 [1.5] 2 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 13 [2.3] 6 [2.3] 8 [2.8] 9 [2.8]
Pigmentation 18 [2.2] 25 [2.2] 17 [2.1] 23 [2.3]
Lymph Node, Mesenteric (49) (49) (48) (45)
Angiectasis 1 [2.0]
Atrophy 2 [2.5] 1 [3.0]
Ectasia 1 [4.0]
Hematopoietic Cell Proliferation 2 [1.5] 2 [2.0] 1 [2.0]
Hemorrhage 1 [4.0] 1 [3.0] 1 [1.0] 5 [2.4]
Hyperplasia, Lymphoid 8 [2.3] 9 [2.4] 7 [2.4] 5 [2.2]
Pigmentation 1 [3.0] 1 [3.0]
Spleen (50) (50) (50) (48)
Hematopoietic Cell Proliferation 34 [2.2] 42 [2.5] 35 [2.5] 34 [2.5]
Necrosis 1 [4.0]
Pigmentation 5 [2.8] 5 [3.0] 1 [3.0] 2 [3.0]
Lymphoid Follicle, Atrophy 1 [2.0] 2 [3.0] 2 [2.5]
Lymphoid Follicle, Hyperplasia 8 [2.5] 11 [2.8] 14 [2.5] 12 [2.5]
Thymus (44) (47) (47) (48)
Atrophy 8 [3.0] 9 [3.0] 11 [2.8] 13 [2.8]
Hemorrhage 1 [3.0]
Hyperplasia, Lymphoid 3 [2.7] 3 [2.0] 2 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 5 [1.8] 6 [2.0] 2 [2.5] 5 [2.2]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50)
Edema 1 [2.0] 1 [4.0] 1 [3.0]
Erosion 1 [3.0]
Ulcer 2 [2.0] 1 [4.0] 1 [1.0] 1 [4.0]
Epidermis, Hyperplasia 2 [3.5] 1 [3.0] 2 [1.5] 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Myelofibrosis 1 [2.0] 2 [2.5] 1 [2.0] 2 [2.5]
Skeletal Muscle (3) (4) (2) (5)
Inflammation, Chronic Active 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Compression 1 [3.0] 1 [3.0] 1 [2.0]
Hemorrhage 2 [2.5]
Necrosis 1 [2.0] 1 [2.0]
Peripheral Nerve (1) (1) (1)
Atrophy 1 [3.0]
Spinal Cord (1) (1) (1)
Necrosis 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 2 [3.0]
Hemorrhage 2 [2.5] 2 [2.0] 3 [2.0]
Hyperplasia, Lymphoid 5 [2.0] 5 [2.2] 1 [2.0] 3 [2.3]
Infiltration Cellular, Histiocyte 1 [3.0] 2 [2.0] 2 [3.5] 4 [1.8]
Alveolar Epithelium, Hyperplasia 3 [1.7] 3 [2.0] 4 [2.0]
Perivascular, Inflammation, Chronic Active 1 [3.0]
Nose (50) (50) (50) (50)
Inflammation, Chronic 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Atrophy 1 [4.0]
Cataract 2 [1.5] 2 [1.5]
Inflammation, Chronic 2 [1.5] 2 [2.5] 3 [2.3] 3 [1.3]
Cornea, Hyperplasia 1 [2.0] 4 [2.3]
Cornea, Mineralization 1 [2.0]
Harderian Gland (49) (50) (50) (50)
Hyperplasia, Focal 2 [3.0] 4 [2.8] 4 [2.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Cyst 1 [3.0] 1 [3.0]
Hydronephrosis 1 [3.0] 1 [2.0]
Hyperplasia, Lymphoid 7 [2.3] 2 [2.5] 5 [2.2] 8 [2.4]
Infarct 3 [1.7] 8 [1.8] 6 [1.8] 8 [2.5]
Nephropathy 14 [1.6] 8 [1.4] 15 [1.7] 12 [1.2]
Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0] 1 [3.0] 2 [3.0] 2 [3.0]
Renal Tubule, Dilatation 2 [2.5] 1 [2.0] 1 [2.0]
Renal Tubule, Necrosis 1 [1.0] 1 [2.0]
Renal Tubule, Pigmentation 1 [4.0] 3 [2.3] 1 [3.0]
Urinary Bladder (50) (49) (50) (49)
Edema 2 [3.0]
Hyperplasia, Lymphoid 3 [3.0] 5 [2.2] 3 [2.0] 2 [2.5]
Transitional Epithelium, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 6 3 6
Natural Death 14 6 13 13
Survivors
Terminal Sacrifice 31 38 34 31
Other 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (43) (49) (48) (46)
Edema 2 [2.0] 2 [2.5] 3 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 1 [3.0]
Intestine Small, Duodenum (42) (50) (46) (48)
Hyperplasia, Lymphoid 1 [2.0]
Intestine Small, Jejunum (44) (49) (46) (45)
Hyperplasia, Lymphoid 2 [2.0] 2 [3.0]
Liver (49) (50) (50) (50)
Angiectasis 1 [3.0]
Basophilic Focus 2 1 2
Clear Cell Focus 10 13 23 13
Congestion 1 [3.0]
Cyst 1 [3.0] 1 [3.0]
Eosinophilic Focus 15 10 15 17
Hematopoietic Cell Proliferation 1 [2.0]
Hemorrhage 1 [3.0]
Hepatodiaphragmatic Nodule 1
Infarct 1 [4.0] 1 [4.0]
Infiltration Cellular, Mixed Cell 2 [2.5] 4 [2.5] 2 [2.5] 2 [2.0]
Mixed Cell Focus 3 7 8 4
Necrosis, Focal 8 [2.9] 7 [2.7] 3 [2.0] 5 [2.6]
Tension Lipidosis 1 1 2
Bile Duct, Cyst 1 [1.0]
Bile Duct, Cyst Multilocular 1
Centrilobular, Necrosis 4 [3.0] 4 [2.3] 5 [2.8]
Hepatocyte, Vacuolization Cytoplasmic 8 [2.8] 9 [3.1] 4 [3.3] 10 [3.0]
Kupffer Cell, Pigmentation 1 [3.0] 1 [2.0] 1 [3.0] 1 [2.0]
Mesentery (7) (7) (10) (7)
Inflammation, Chronic 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 5 [3.4] 6 [2.8] 7 [3.1] 4 [2.8]
Pancreas (46) (50) (50) (49)
Necrosis 1 [4.0]
Acinus, Cytoplasmic Alteration 2 [3.0] 2 [3.0] 2 [3.0]
Salivary Glands (49) (50) (50) (50)
Atrophy 1 [2.0] 2 [2.0]
Hyperplasia, Lymphoid 3 [2.0] 4 [2.0] 6 [2.5] 1 [2.0]
Stomach, Forestomach (49) (50) (50) (50)
Diverticulum 2 1
Erosion 1 [2.0] 1 [2.0] 2 [1.5]
Inflammation, Chronic 3 [2.0] 1 [3.0] 3 [2.3] 6 [2.5]
Ulcer 2 [1.0] 2 [2.5] 2 [2.5] 2 [2.0]
Epithelium, Hyperplasia 4 [2.3] 3 [3.0] 4 [2.8] 7 [2.4]
Epithelium, Hyperplasia, Focal 1 [3.0] 1 [3.0]
Stomach, Glandular (47) (50) (50) (50)
Erosion 2 [3.0] 2 [2.0] 1 [3.0]
Glands, Hyperplasia 1 [2.0]
Tooth (5) (6)
Malformation 5 6
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 1 [2.0] 1 [1.0]
Inflammation, Chronic 1 [2.0]
Mineralization 3 [2.3] 2 [2.0] 1 [2.0]
Myocardium, Necrosis 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 7 [3.0] 5 [3.0] 4 [3.0] 6 [3.0]
Hyperplasia, Focal 4 [1.8] 7 [2.3] 5 [1.8] 1 [2.0]
Hypertrophy 1 [3.0] 1 [2.0]
Hypertrophy, Focal 12 [1.8] 11 [1.5] 13 [1.8] 6 [1.7]
Capsule, Hyperplasia 7 [2.3] 4 [2.8] 1 [2.0] 5 [2.4]
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 1 [2.0] 1 [1.0] 1 [1.0]
Islets, Pancreatic (46) (50) (50) (49)
Atrophy 1 [4.0]
Hyperplasia 34 [2.2] 32 [2.4] 26 [2.3] 13 [1.8]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (45) (47) (49) (47)
Cyst 2 [2.5] 3 [3.0] 4 [3.0]
Pituitary Gland (45) (50) (48) (48)
Pars Distalis, Cyst 7 [3.0] 7 [3.0] 7 [3.0] 5 [3.0]
Pars Distalis, Hyperplasia, Focal 1 [3.0] 1 [1.0]
Thyroid Gland (48) (50) (50) (50)
Degeneration, Cystic 5 [2.0] 8 [1.6] 3 [1.7] 6 [1.8]
Follicular Cell, Hyperplasia 3 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Atypia Cellular 5 [2.4] 4 [2.5] 2 [2.0] 6 [2.3]
Granuloma Sperm 1 [4.0] 2 [3.5] 2 [3.5] 2 [2.5]
Spermatocele 1 [3.0] 1 [3.0]
Preputial Gland (49) (50) (50) (50)
Cyst 25 [2.9] 26 [3.0] 33 [3.0] 33 [3.0]
Inflammation, Chronic 21 [2.1] 30 [2.3] 24 [2.3] 28 [2.2]
Prostate (48) (50) (50) (49)
Inflammation, Chronic 4 [2.8] 1 [3.0]
Seminal Vesicle (49) (50) (50) (50)
Degeneration 3 [3.0] 5 [3.0] 1 [3.0]
Inflammation, Chronic 1 [3.0]
Testes (49) (50) (50) (50)
Germinal Epithelium, Atrophy 9 [2.1] 4 [2.0] 4 [1.5] 8 [1.9]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (50) (50) (50)
Angiectasis 1 [2.0]
Depletion Cellular 1 [2.0]
Hyperplasia 22 [2.5] 22 [2.7] 28 [2.7] 32 [2.6]
Lymph Node (1) (2) (5) (1)
Bronchial, Hyperplasia, Lymphoid 1 [3.0]
Iliac, Ectasia 1 [2.0]
Inguinal, Hyperplasia, Lymphoid 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
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HEMATOPOIETIC SYSTEM - CONT
Inguinal, Pigmentation 1 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0]
Mediastinal, Pigmentation 1 [3.0]
Pancreatic, Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mandibular (48) (50) (48) (48)
Atrophy 5 [2.4] 2 [2.5] 3 [2.0] 7 [2.1]
Hematopoietic Cell Proliferation 1 [2.0]
Hemorrhage 1 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 15 [2.5] 14 [2.2] 6 [2.5] 7 [2.3]
Pigmentation 7 [2.1] 8 [2.0] 1 [2.0] 7 [2.1]
Lymph Node, Mesenteric (46) (49) (49) (47)
Atrophy 4 [2.5] 2 [2.5] 1 [2.0] 9 [2.3]
Hematopoietic Cell Proliferation 1 [2.0] 1 [1.0] 3 [1.7] 3 [2.0]
Hemorrhage 8 [1.9] 5 [2.0] 9 [1.7] 7 [2.0]
Hyperplasia, Lymphoid 2 [2.5] 8 [2.5] 3 [2.7] 6 [2.5]
Hyperplasia, Plasma Cell 1 [3.0]
Spleen (47) (50) (50) (50)
Angiectasis 1 [2.0]
Hematopoietic Cell Proliferation 18 [3.1] 20 [2.6] 28 [2.8] 38 [2.9]
Pigmentation 1 [2.0] 1 [3.0] 1 [2.0]
Lymphoid Follicle, Atrophy 4 [2.5] 7 [2.7] 3 [2.7] 8 [2.8]
Lymphoid Follicle, Hyperplasia 3 [2.3] 6 [2.5] 6 [2.7] 6 [2.3]
Thymus (42) (45) (46) (47)
Atrophy 14 [3.1] 16 [2.9] 12 [2.8] 22 [3.0]
Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 1 [4.0]
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INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Cyst Epithelial Inclusion 2 [3.0]
Ulcer 3 [4.0] 2 [4.0] 3 [4.0]
Epidermis, Hyperplasia 3 [2.0] 2 [2.5] 3 [3.3]
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MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Hyperostosis 1 [2.0]
Cranium, Hyperostosis 1 [3.0] 1 [3.0]
Skeletal Muscle (1) (1) (1)
Atrophy 1 [1.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (2) (2) (1)
Atrophy 1 [1.0] 1 [3.0]
Spinal Cord (2) (2) (1)
Gliosis 1 [3.0]
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RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Edema 2 [2.0] 1 [3.0] 2 [2.0]
Hemorrhage 2 [2.5] 4 [1.5]
Hyperplasia, Lymphoid 3 [2.7] 1 [2.0]
Infiltration Cellular, Histiocyte 2 [1.0] 6 [2.3] 3 [2.3] 6 [3.2]
Metaplasia, Osseous 1 [1.0] 2 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 2 [1.5] 6 [1.7] 6 [2.3] 7 [1.9]
Bronchiole, Hyperplasia 1 [1.0]
Nose (48) (50) (50) (50)
Foreign Body 1
Inflammation, Chronic 1 [2.0] 1 [3.0] 3 [2.0]
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SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (50)
Atrophy 1 [4.0]
Cataract 1 [2.0] 1 [1.0] 5 [1.4]
Inflammation, Chronic 2 [1.5] 2 [2.0]
Bilateral, Cataract 1 [3.0]
Cornea, Hyperplasia 1 [2.0] 1 [2.0]
Harderian Gland (49) (50) (50) (50)
Cyst 1 [3.0]
Hyperplasia, Focal 5 [2.6] 1 [4.0] 1 [3.0] 1 [3.0]
Lacrimal Gland (1)
Cyst 1 [3.0]
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URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 9 [3.0] 13 [3.0] 14 [3.0] 11 [3.0]
Hydronephrosis 4 [2.0] 2 [2.5] 4 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/19/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 09:37:47
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia, Lymphoid 5 [2.6] 5 [2.0] 6 [2.3] 5 [2.4]
Infarct 3 [1.7] 7 [2.3] 4 [2.0] 5 [1.8]
Inflammation, Suppurative 1 [3.0] 1 [4.0]
Metaplasia, Osseous 6 [2.2] 3 [2.3] 2 [2.0] 2 [3.0]
Nephropathy 36 [1.8] 44 [1.5] 42 [1.7] 39 [1.8]
Papilla, Necrosis 1 [3.0]
Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0]
Renal Tubule, Dilatation 1 [3.0] 3 [2.3] 1 [3.0]
Renal Tubule, Hyperplasia 1 [2.0] 1 [1.0] 1 [1.0] 3 [1.7]
Renal Tubule, Necrosis 1 [2.0]
Renal Tubule, Pigmentation 1 [4.0] 3 [2.7] 2 [2.5] 7 [3.0]
Transitional Epithelium, Hyperplasia 1 [2.0]
Urethra (3)
Angiectasis 3 [4.0]
Inflammation, Chronic Active 3 [2.7]
Urinary Bladder (49) (50) (50) (49)
Edema 1 [3.0]
Hemorrhage 1 [2.0]
Hyperplasia, Lymphoid 1 [2.0] 1 [3.0]
Inflammation, Chronic 1 [2.0]
Transitional Epithelium, Hyperplasia 1 [1.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
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