TDMS Study 93020-07 Pathology Tables
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
FINAL #1 RATS
Facility: Southern Research Institute
Chemical CAS #: 693-13-0
Lock Date: 03/14/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 13 9 10 14
Natural Death 7 9 8 10
Survivors
Terminal Sacrifice 30 32 32 25
Other 1
Animals Examined Microscopically 50 50 50 49
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ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (49) (49)
Intestine Large, Cecum (50) (50) (50) (49)
Intestine Small, Duodenum (49) (50) (50) (49)
Leiomyoma 1 (2%)
Intestine Small, Jejunum (47) (50) (50) (46)
Intestine Small, Ileum (48) (49) (50) (49)
Liver (50) (50) (50) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatocellular Adenoma 6 (12%) 1 (2%) 2 (4%) 1 (2%)
Mesentery (11) (12) (9) (9)
Fibrosarcoma 1 (11%)
Oral Mucosa (1) (2)
Squamous Cell Carcinoma 1 (100%) 1 (50%)
Pancreas (50) (50) (50) (49)
Salivary Glands (50) (50) (50) (48)
Stomach, Forestomach (50) (50) (50) (49)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (49)
Tongue (2) (1)
Squamous Cell Papilloma 2 (100%) 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adenoma 3 (6%) 1 (2%)
Adrenal Medulla (49) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 2 (4%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Adenoma 28 (56%) 32 (64%) 30 (60%) 24 (49%)
Pars Distalis, Adenoma, Multiple 5 (10%) 2 (4%) 3 (6%) 3 (6%)
Pars Distalis, Carcinoma 3 (6%) 1 (2%) 1 (2%) 4 (8%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (49)
C-Cell, Adenoma 3 (6%) 2 (4%) 6 (12%) 6 (12%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 3 (6%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (49)
Adenoma 2 (4%) 3 (6%) 5 (10%) 2 (4%)
Carcinoma 2 (4%) 6 (12%) 2 (4%)
Carcinoma, Multiple 1 (2%)
Ovary (50) (50) (50) (49)
Uterus (50) (50) (50) (49)
Carcinoma 2 (4%)
Leiomyoma 1 (2%) 1 (2%)
Polyp Stromal 10 (20%) 10 (20%) 9 (18%) 9 (18%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Vagina (6) (6) (5) (11)
Granular Cell Tumor Benign 1 (17%)
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Page 3
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Lymph Node (13) (10) (14) (8)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (8%) 1 (13%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (8%) 1 (13%)
Renal, Carcinoma, Metastatic, Thyroid Gland 1 (13%)
Lymph Node, Mandibular (3) (7) (1) (2)
Lymph Node, Mesenteric (50) (50) (50) (48)
Spleen (50) (50) (50) (49)
Thymus (50) (48) (49) (46)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (48)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 4 (8%) 2 (4%)
Fibroadenoma 10 (20%) 9 (18%) 20 (40%) 13 (27%)
Fibroadenoma, Multiple 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Skin (50) (50) (50) (49)
Keratoacanthoma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Carcinoma, Metastatic, Pituitary Gland 3 (6%) 2 (4%)
Glioma Malignant, Mixed Cell 2 (4%) 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (49)
Iris, Amelanotic Melanoma, Benign 1 (2%)
Harderian Gland (50) (50) (50) (49)
Adenoma 1 (2%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49)
Leukemia Mononuclear 9 (18%) 9 (18%) 7 (14%) 15 (31%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 45 44 45
Total Primary Neoplasms 99 89 100 103
Total Animals with Benign Neoplasms 44 41 41 39
Total Benign Neoplasms 74 70 83 74
Total Animals with Malignant Neoplasms 22 14 16 23
Total Malignant Neoplasms 25 19 17 29
Total Animals with Metastatic Neoplasms 4 3
Total Metastatic Neoplasm 6 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 12 8 8 10
Moribund Sacrifice 18 12 10 23
Survivors
Terminal Sacrifice 20 30 32 17
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Intestine Large, Cecum (50) (50) (50) (49)
Intestine Small, Duodenum (49) (49) (49) (49)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Intestine Small, Jejunum (49) (49) (48) (49)
Intestine Small, Ileum (49) (49) (50) (48)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Mesentery (9) (9) (12) (6)
Schwannoma Malignant 1 (11%) 1 (17%)
Oral Mucosa (2)
Squamous Cell Carcinoma 2 (100%)
Pancreas (50) (50) (50) (50)
Mixed Tumor Malignant 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Acinus, Adenoma 3 (6%) 1 (2%) 2 (4%)
Salivary Glands (49) (50) (50) (50)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (49)
Tongue (1) (1) (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Adrenal Medulla (50) (48) (50) (50)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 3 (6%) 4 (8%) 4 (8%) 2 (4%)
Pheochromocytoma Malignant, Multiple 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 3 (6%) 2 (4%) 8 (16%) 7 (14%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 4 (8%) 12 (24%) 9 (18%) 5 (10%)
Adenoma, Multiple 1 (2%) 1 (2%)
Carcinoma 2 (4%) 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (49) (48)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 28 (56%) 33 (66%) 38 (76%) 17 (34%)
Pars Distalis, Adenoma, Multiple 1 (2%) 4 (8%) 3 (6%)
Pars Distalis, Carcinoma 5 (10%) 1 (2%) 2 (4%)
Pars Intermedia, Adenoma 2 (4%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Sarcoma, Metastatic, Salivary Glands 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (6%) 8 (16%) 8 (16%) 4 (8%)
C-Cell, Adenoma, Multiple 1 (2%) 1 (2%)
C-Cell, Carcinoma 5 (10%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Hemangioma 1 (100%)
Lipoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Carcinoma 1 (2%) 2 (4%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 21 (42%) 27 (54%) 15 (30%) 14 (28%)
Interstitial Cell, Adenoma 15 (30%) 10 (20%) 16 (32%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (18) (14) (16) (13)
Mediastinal, Hemangiosarcoma 1 (6%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Spleen (50) (50) (50) (50)
Thymus (49) (46) (46) (49)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (48) (47) (48)
Carcinoma 1 (2%)
Fibroadenoma 4 (8%) 1 (2%) 1 (2%)
Skin (49) (50) (50) (50)
Keratoacanthoma 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 4 (8%) 2 (4%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 3 (6%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (3) (1) (1) (5)
Lipoma 1 (33%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 5 (10%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%) 2 (4%)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Harderian Gland (50) (50) (50) (50)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Page 10
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 13 (26%) 22 (44%) 13 (26%) 6 (12%)
Lymphoma Malignant 2 (4%) 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 93020-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 06/30/04
Route: SKIN APPLICATION Time: 11:19:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 33
Total Primary Neoplasms 141 154 148 89
Total Animals with Benign Neoplasms 47 48 50 32
Total Benign Neoplasms 99 117 115 70
Total Animals with Malignant Neoplasms 34 31 27 15
Total Malignant Neoplasms 42 37 33 19
Total Animals with Metastatic Neoplasms 7 2 3 1
Total Metastatic Neoplasm 7 5 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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