TDMS Study 93020-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 04/04/03
EXPERIMENT: 93020 TEST: 07 TIME: 07:50:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES 05451 ROUTE: SKIN APPLICATION NTP C#: 93020D
PATHOLOGIST: HEATH, JAMES CAS: 693-13-0
------------------------------------------------------------------------------------------------------------------------------------
DRAFT RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 04/04/03
EXPERIMENT: 93020 TEST: 07 TIME: 07:50:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES 05451 ROUTE: SKIN APPLICATION NTP C#: 93020D
PATHOLOGIST: HEATH, JAMES CAS: 693-13-0
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 463 522 533 533 533 535 582 593 593 599 |
| 606 608 612 637 637 657 662 676 677 677 |
| 687 688 690 692 697 701 705 714 716 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 444 485 522 542 546 571 575 593 593 600 |
| 601 603 617 621 654 673 676 682 703 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 444 491 556 563 615 645 647 649 652 660 |
| 663 676 686 688 694 696 703 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 204 237 237 266 273 277 277 278 278 278 |
| 281 285 290 290 298 298 319 325 513 553 |
| 606 607 617 623 630 634 667 669 676 683 |
| 691 704 706 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 88.0 80.0 66.0 40.0 |
| | |
| | |
|10 MG/KG | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 76.0 70.0 60.0 |
| | |
| | |
|20 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 78.0 64.0 |
| | |
| | |
|40 MG/KG | 100.0 100.0 92.0 64.0 64.0 64.0 62.0 60.0 48.0 34.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.0% 60.0% 64.0% 34.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.056 P=0.135N P=0.025N P=0.141 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.4 600.9 636.0 441.5 |
|NATURAL DEATHS (C) | (12.8) (16.0) (17.8) (32.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.4 677.7 695.5 539.3 |
|(STANDARD ERROR) | (10.3) (11.0) ( 9.0) (28.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 241 359 394 437 535 550 556 606 621 626 |
| 632 632 654 667 673 676 682 703 710 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 248 327 347 513 522 522 554 570 593 595 |
| 621 652 669 677 703 712 723 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 384 465 535 535 536 570 606 641 646 649 |
| 682 684 686 690 701 703 712 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 446 456 469 559 587 593 593 601 617 617 |
| 627 646 662 663 667 670 673 691 697 703 |
| 703 705 713 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 98.0 96.0 94.0 92.0 90.0 86.0 74.0 60.0 |
| | |
| | |
|10 MG/KG | 100.0 100.0 98.0 94.0 94.0 94.0 88.0 80.0 76.0 64.0 |
| | |
| | |
|20 MG/KG | 100.0 100.0 100.0 100.0 98.0 96.0 90.0 88.0 80.0 64.0 |
| | |
| | |
|40 MG/KG | 100.0 100.0 100.0 100.0 100.0 93.9 93.9 83.7 71.4 51.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 64.0% 64.0% 51.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.415 P=0.838N P=0.710N P=0.562 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 583.9 570.9 619.3 628.5 |
|NATURAL DEATHS (C) | (29.3) (33.3) (22.5) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.9 672.1 689.5 679.8 |
|(STANDARD ERROR) | (15.4) (16.0) (11.0) (10.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIISOPROPYLCARBODIIMIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
10 MG/KG = 2
20 MG/KG = 3
40 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1
| 4 4 2 1 23 1
| 4 4 23 1 12 33
| 44 3 3
90 + 44 2 2 3 3
| 1 221
P | 21 1 33
E | 11 3 3
R 80 + 44 11
C | 22 3 3
E | 44 112 1 333
N | 44 2 2 33
T 70 + 1 1 2
| 4 4 1 1 33
S | 44 4 1 12 2 3 3
U | 4 4 2 2
R 60 + 4 4 1 1 2 2
V |
I | 4 4
V | 44 11
A 50 + 44 11
L | 4 4
| 44 111
| 44
40 + 44 1 1
| 4 4
| 4 4
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
DIISOPROPYLCARBODIIMIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
10 MG/KG = 2
20 MG/KG = 3
40 MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 12 3 4
|
| 12 2 1 3 4 43
| 2 2 1 1 43 3
95 +
| 2 1 1 4 2 4
| 1 2 2 1
| 4 4
90 + 1 1 3 4 4
|
| 2 11 3 3
| 1 2 441 3
P 85 +
E | 2 241 1 33
R | 11
C |
E 80 + 2 211 3 3
N |
T | 24 42
| 1 1 2
S 75 + 4 4
U | 1 1233
R | 11 3 2
V | 44
I 70 + 22
V |
A | 411 32 2
L | 1 13 3
65 + 4 4
| 4411 2 2
| 1 1
| 44
60 + 1 1
|
|
|
55 + 44
|
| 4 4
| 4 4
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.