TDMS Study 54591-09 Pathology Tables
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
Facility: BIORELIANCE
Chemical CAS #: 156-60-5
Lock Date: 02/14/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 5 5 3 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Uterus (10) (10) (1) (4) (2) (1)
Endometrium, Polyp Stromal 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 3
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1
Total Primary Neoplasms 1
Total Animals with Benign Neoplasms 1
Total Benign Neoplasms 1
Total Animals with Malignant Neoplasms
Total Malignant Neoplasms
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 4
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 6
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 1 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 8
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:57:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 50000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 10
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