TDMS Study 54591-09 Pathology Tables
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
Facility: BIORELIANCE
Chemical CAS #: 156-60-5
Lock Date: 02/14/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 5 5 3 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (2) (1) (1)
Hepatodiaphragmatic Nodule 1 (10%) 2 (20%) 1 (50%) 1 (100%)
Inflammation, Chronic 1 (10%)
Pancreas (10) (10)
Acinus, Atrophy, Focal 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%) 1 (10%)
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10)
Inflammation, Chronic 1 (10%) 3 (30%)
Bilateral, Inflammation, Chronic 2 (20%) 3 (30%)
Ovary (10) (10) (2) (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 2 (100%) 1 (100%) 1 (100%)
Uterus (10) (10) (1) (4) (2) (1)
Hydrometra 2 (20%) 3 (30%) 1 (100%) 4 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10)
Atrophy 1 (10%)
Inflammation, Granulomatous 4 (40%) 2 (20%)
Myelofibrosis 1 (10%)
Lymph Node, Mandibular (10) (10)
Hemorrhage 1 (10%)
Lymph Node, Mesenteric (10) (10)
Hyperplasia, Lymphoid 1 (10%)
Infiltration Cellular, Histiocyte 5 (50%) 2 (20%)
Spleen (10) (10) (1)
Capsule, Fibrosis 1 (100%)
Thymus (10) (10)
Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Interstitium, Inflammation, Chronic 1 (10%)
Nose (10) (10)
Inflammation, Chronic 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy, Chronic 2 (20%)
Bilateral, Mineralization, Focal 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10)
Hepatodiaphragmatic Nodule 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10)
Cardiomyopathy 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10)
Infiltration Cellular, Chronic 1 (10%)
Inflammation, Chronic 1 (10%)
Bilateral, Inflammation, Chronic 2 (20%)
Ovary (10)
Cyst 1 (10%)
Uterus (10)
Hydrometra 4 (40%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10)
Inflammation, Granulomatous 2 (20%)
Myelofibrosis 3 (30%)
Lymph Node, Mesenteric (10)
Infiltration Cellular, Histiocyte 3 (30%)
Thymus (10)
Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10)
Hemorrhage 1 (10%)
Interstitium, Inflammation, Chronic 4 (40%)
Nose (10)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Bilateral, Mineralization, Focal 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 1 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (1) (2)
Hepatodiaphragmatic Nodule 1 (100%) 1 (50%)
Inflammation, Chronic 1 (10%)
Pancreas (10) (10)
Acinus, Atrophy, Focal 3 (30%) 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 9 (90%) 6 (60%)
Pigmentation 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10)
Ultimobranchial Cyst 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10)
Inflammation, Chronic 6 (60%) 2 (20%)
Inflammation, Chronic Active 1 (10%)
Bilateral, Inflammation, Chronic 2 (20%) 3 (30%)
Testes (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Germinal Epithelium, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (10) (10)
Infiltration Cellular, Histiocyte 1 (10%)
Spleen (10) (10)
Capsule, Inflammation, Chronic, Focal 1 (10%)
Thymus (10) (10)
Hemorrhage 3 (30%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage 2 (20%) 1 (10%)
Interstitium, Inflammation, Chronic 1 (10%) 1 (10%)
Interstitium, Inflammation, Chronic Active 1 (10%)
Nose (10) (10)
Fungus 1 (10%)
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy, Chronic 3 (30%)
Bilateral, Nephropathy, Chronic 9 (90%) 7 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10)
Cardiomyopathy 7 (70%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (9)
Inflammation, Chronic 1 (11%)
Bilateral, Inflammation, Chronic 2 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10)
Hemorrhage 2 (20%)
Lymph Node, Mesenteric (10)
Infiltration Cellular, Histiocyte 3 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 54591-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:56:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 50000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (9)
Hemorrhage 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10)
Hemorrhage 3 (30%)
Interstitium, Inflammation, Chronic 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Nephropathy, Chronic 4 (40%)
Bilateral, Nephropathy, Chronic 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------