TDMS Study 97013-06 Pathology Tables
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 64 MG/KG
Include 006 128 MG/KG
Include 008 256 MG/KG
Include 001 0 MG/KG
Include 003 64 MG/KG
Include 005 128 MG/KG
Include 007 256 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 3 1 4
Natural Death 2 2 2 1
Survivors
Terminal Sacrifice 11 10 12 10
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0] 3 [1.0]
Inflammation 14 [1.1] 11 [1.0] 14 [1.1] 11 [1.1]
Necrosis 3 [1.0] 2 [1.0] 4 [1.0] 2 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 3 [1.0] 7 [1.0] 5 [1.0] 5 [1.0]
Mesentery (1)
Necrosis 1 [3.0]
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 [1.0]
Epithelium, Hyperkeratosis 1 [2.0]
Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 8 [1.0] 8 [1.0] 11 [1.0] 5 [1.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 4 [1.0] 1 [1.0] 1 [1.0] 2 [1.0]
Thyroid Gland (15) (15) (15) (15)
Cyst 2 [1.5] 1 [2.0] 1 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (14) (15) (15)
Cyst 1 [1.0] 2 [1.0]
Uterus (15) (15) (15) (15)
Inflammation, Suppurative 2 [1.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 7 [1.3] 6 [1.2] 10 [1.3] 6 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hyperplasia 1 [1.0]
Lymph Node, Mandibular (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [2.0] 1 [1.0] 1 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0] 1 [1.0] 1 [1.0] 4 [1.3]
Thymus (15) (15) (15) (14)
Atrophy 3 [2.7] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [4.0]
Artery, Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Retina, Degeneration 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 6 [1.0] 5 [1.0] 5 [1.0] 4 [1.0]
Cyst 2 [1.0] 2 [1.0] 1 [1.0]
Hydronephrosis 1 [1.0]
Mineralization 1 [1.0]
Nephropathy 2 [1.0] 3 [1.0]
Artery, Inflammation 1 [2.0] 1 [1.0]
Renal Tubule, Hypertrophy 1 [1.0] 1 [1.0] 4 [1.0]
Renal Tubule, Necrosis 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 1
Natural Death 2
Survivors
Terminal Sacrifice 13 14 15 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0]
Inflammation 8 [1.1] 8 [1.0] 5 [1.0] 6 [1.0]
Necrosis 1 [1.0] 1 [1.0] 1 [1.0] 2 [1.5]
Hepatocyte, Fatty Change 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 4 [1.0] 2 [1.0] 5 [1.0] 4 [1.0]
Mesentery (1)
Fat, Necrosis 1 [2.0]
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 1 [1.0]
Hypertrophy 9 [1.1] 9 [1.1] 6 [1.5] 8 [1.1]
Vacuolization Cytoplasmic 1 [1.0]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0] 2 [1.0]
Thyroid Gland (15) (15) (15) (15)
Cyst 1 [2.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (15) (15) (15) (15)
Germinal Epithelium, Degeneration 3 [1.7] 1 [2.0] 2 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (14) (14)
Atrophy 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [2.0]
Lymph Node, Mesenteric (14) (15) (15) (15)
Atrophy 1 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 2 [1.0] 1 [1.0] 1 [1.0]
Lymphoid Follicle, Atrophy 1 [2.0]
Lymphoid Follicle, Hyperplasia 1 [2.0]
Thymus (15) (15) (15) (15)
Atrophy 1 [3.0] 1 [1.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia, Focal 1 [1.0]
Subcutaneous Tissue, Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:41:45
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 [1.0] 1 [1.0]
Thrombosis 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 [1.0] 1 [1.0] 2 [1.0]
Cyst 1 [1.0] 1 [1.0]
Hydronephrosis 1 [1.0] 1 [1.0]
Inflammation 1 [2.0]
Nephropathy 7 [1.0] 6 [1.0] 7 [1.0] 6 [1.0]
Artery, Inflammation 1 [1.0] 1 [1.0]
Renal Tubule, Dilatation 1 [1.0] 1 [1.0]
Renal Tubule, Hypertrophy 1 [1.0]
Renal Tubule, Necrosis 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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