TDMS Study 97013-07 Pathology Tables
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 75-27-4 Lock Date: 07/19/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Moribund Sacrifice 1 1 Dosing Accident 1 Survivors Terminal Sacrifice 15 14 14 14 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (2) Lumbar, Osteosarcoma, Metastatic, Uncertain Primary Site 1 (50%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (2) Subcutaneous Tissue, Osteosarcoma 1 (50%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None Page 3 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 1 Total Primary Neoplasms 1 Total Animals with Benign Neoplasms Total Benign Neoplasms Total Animals with Malignant Neoplasms 1 Total Malignant Neoplasms 1 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 3 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Survivors Terminal Sacrifice 15 15 15 15 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) Histiocytic Sarcoma 1 (7%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Alveolar/Bronchiolar Carcinoma 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) Histiocytic Sarcoma 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:43:26 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 2 Total Primary Neoplasms 2 Total Animals with Benign Neoplasms Total Benign Neoplasms Total Animals with Malignant Neoplasms 2 Total Malignant Neoplasms 2 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------