TDMS Study 97013-08 Pathology Tables
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 25 MG/KG
Include 006 50 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 25 MG/KG
Include 005 50 MG/KG
Include 007 100 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Dosing Accident 1 1
Natural Death 2 1 2
Survivors
Terminal Sacrifice 11 14 13 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1) (1)
Perforation 1 (100%) 1 (100%)
Liver (15) (15) (15) (15)
Basophilic Focus 1 (7%)
Cyst 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 1 (7%)
Hemorrhage 1 (7%)
Hepatodiaphragmatic Nodule 1 (7%)
Inflammation 11 (73%) 13 (87%) 13 (87%) 13 (87%)
Necrosis 1 (7%) 4 (27%) 1 (7%)
Hepatocyte, Fatty Change 5 (33%) 8 (53%) 7 (47%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 3 (20%)
Salivary Glands (1) (1)
Atrophy 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 (7%)
Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Mineralization 1 (7%)
Subcapsular, Hyperplasia 7 (47%) 10 (67%) 8 (53%) 6 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (15) (15) (15) (15)
Angiectasis 1 (7%)
Cyst 1 (7%) 1 (7%) 2 (13%)
Thyroid Gland (15) (15) (15) (15)
Cyst 2 (13%) 2 (13%) 3 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Atrophy 1 (7%)
Cyst 4 (27%) 2 (13%) 4 (27%) 4 (27%)
Uterus (15) (15) (15) (15)
Atrophy 1 (7%)
Inflammation 1 (7%)
Endometrium, Hyperplasia, Cystic 12 (80%) 9 (60%) 12 (80%) 13 (87%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (14) (15) (15) (15)
Hyperplasia 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%) 1 (7%)
Lymph Node, Mesenteric (14) (15) (15) (15)
Atrophy 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 1 (7%)
Lymphoid Follicle, Atrophy 3 (20%) 1 (7%)
Thymus (13) (15) (15) (15)
Atrophy 2 (15%) 3 (20%) 1 (7%) 3 (20%)
Cyst 2 (15%) 5 (33%) 5 (33%) 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 2 (13%)
Thrombosis 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 4 (27%) 5 (33%) 5 (33%) 4 (27%)
Cyst 1 (7%) 2 (13%)
Mineralization 1 (7%)
Nephropathy 1 (7%) 3 (20%) 3 (20%) 1 (7%)
Renal Tubule, Degeneration 1 (7%)
Renal Tubule, Dilatation 1 (7%)
Renal Tubule, Hypertrophy 1 (7%) 1 (7%) 1 (7%) 8 (53%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Dosing Accident 1
Moribund Sacrifice 1 1 3
Survivors
Terminal Sacrifice 13 14 12 14
Natural Death 1
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Inflammation 1 (100%)
Liver (15) (15) (15) (15)
Cyst 1 (7%)
Hematopoietic Cell Proliferation 1 (7%)
Inflammation 6 (40%) 7 (47%) 9 (60%) 8 (53%)
Necrosis 1 (7%) 1 (7%)
Hepatocyte, Fatty Change 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 1 (7%) 3 (20%) 3 (20%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 (7%)
Tooth (3) (2) (3) (3)
Inflammation 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 6 (40%) 8 (53%) 5 (33%) 7 (47%)
Subcapsular, Hyperplasia 2 (13%)
Pituitary Gland (15) (15) (15) (15)
Cyst 2 (13%) 2 (13%) 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (15) (15) (15) (15)
Cyst 2 (13%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Inflammation 1 (7%)
Preputial Gland (2)
Cyst 1 (50%)
Duct, Ectasia 1 (50%)
Testes (15) (15) (15) (15)
Germinal Epithelium, Degeneration 1 (7%) 4 (27%) 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Atrophy 1 (7%)
Hyperplasia 1 (7%) 2 (13%)
Infiltration Cellular, Plasma Cell 2 (13%)
Lymph Node, Mesenteric (15) (14) (15) (15)
Atrophy 1 (7%) 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 2 (13%)
Lymphoid Follicle, Atrophy 1 (7%) 1 (7%)
Thymus (14) (15) (15) (15)
Atrophy 2 (14%) 1 (7%) 3 (20%) 2 (13%)
Cyst 7 (50%) 5 (33%) 4 (27%) 8 (53%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:45:50
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Edema 1 (7%)
Inflammation 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 (20%) 6 (40%)
Cyst 1 (7%)
Hydronephrosis 1 (7%)
Nephropathy 2 (13%) 8 (53%) 3 (20%) 4 (27%)
Artery, Inflammation 1 (7%)
Renal Tubule, Degeneration 4 (27%)
Renal Tubule, Dilatation 2 (13%) 1 (7%) 5 (33%) 4 (27%)
Renal Tubule, Hypertrophy 4 (27%) 1 (7%)
Renal Tubule, Necrosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
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