TDMS Study 97013-08 Pathology Tables
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 75-27-4 Lock Date: 07/19/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 002 0 MG/KG Include 004 25 MG/KG Include 006 50 MG/KG Include 008 100 MG/KG Include 001 0 MG/KG Include 003 25 MG/KG Include 005 50 MG/KG Include 007 100 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Moribund Sacrifice 1 1 Dosing Accident 1 1 Natural Death 2 1 2 Survivors Terminal Sacrifice 11 14 13 13 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Salivary Glands (1) (1) Duct, Carcinoma 1 (100%) 1 (100%) Stomach, Forestomach (15) (15) (15) (15) Squamous Cell Papilloma 3 (20%) 3 (20%) 4 (27%) Squamous Cell Papilloma, Multiple 3 (20%) 5 (33%) 6 (40%) 11 (73%) Tooth (4) (3) (2) Odontogenic Tumor 4 (100%) 3 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Adrenal Medulla (15) (15) (15) (15) Pituitary Gland (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Uterus (15) (15) (15) (15) Polyp Stromal 1 (7%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Lymph Node, Mandibular (14) (15) (15) (15) Lymph Node, Mesenteric (14) (15) (15) (15) Spleen (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (1) (3) (6) (2) Squamous Cell Papilloma 1 (100%) 1 (33%) 5 (83%) 2 (100%) Squamous Cell Papilloma, Multiple 2 (67%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Adenoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) Leukemia Erythrocytic 2 (13%) 2 (13%) 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 10 10 12 13 Total Primary Neoplasms 14 14 20 16 Total Animals with Benign Neoplasms 7 9 12 12 Total Benign Neoplasms 7 12 16 13 Total Animals with Malignant Neoplasms 3 2 1 1 Total Malignant Neoplasms 3 2 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 4 3 2 Total Uncertain Neoplasms 4 3 2 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Dosing Accident 1 Moribund Sacrifice 1 1 3 Survivors Terminal Sacrifice 13 14 12 14 Natural Death 1 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Stomach, Forestomach (15) (15) (15) (15) Squamous Cell Papilloma 4 (27%) 2 (13%) 2 (13%) 5 (33%) Squamous Cell Papilloma, Multiple 5 (33%) 3 (20%) 9 (60%) 7 (47%) Tooth (3) (2) (3) (3) Odontogenic Tumor 2 (67%) 2 (100%) 3 (100%) 2 (67%) Sarcoma 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Adrenal Medulla (15) (15) (15) (15) Pituitary Gland (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (1) (1) (1) (5) Squamous Cell Papilloma 1 (100%) 4 (80%) Squamous Cell Papilloma, Multiple 1 (100%) 1 (20%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Page 7 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) Leukemia Erythrocytic 1 (7%) 1 (7%) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04 Route: GAVAGE Time: 08:47:29 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 11 6 13 14 Total Primary Neoplasms 14 9 15 21 Total Animals with Benign Neoplasms 9 5 11 13 Total Benign Neoplasms 10 6 12 18 Total Animals with Malignant Neoplasms 2 1 1 Total Malignant Neoplasms 2 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 2 2 3 2 Total Uncertain Neoplasms 2 2 3 2 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------