TDMS Study 97013-08 Pathology Tables
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 25 MG/KG
Include 006 50 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 25 MG/KG
Include 005 50 MG/KG
Include 007 100 MG/KG
Page 1
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 6| 4| 8| 8| 8| 8| 8| 8| 6| 8| 6| | |
| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 1| 3| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Perforation | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Basophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 6| 4| 8| 8| 8| 8| 8| 8| 6| 8| 6| | |
| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 1| 3| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + | 14 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Lymphoid Follicle, Atrophy | 1 3 1 | 3 1.7|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + M | 13 |
Atrophy | 4 2 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 6| 4| 8| 8| 8| 8| 8| 8| 6| 8| 6| | |
| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 1| 3| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 1 1 1 | 4 1.0|
Nephropathy | 1 | 1 1.0|
Renal Tubule, Dilatation | 1 | 1 1.0|
Renal Tubule, Hypertrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
Hepatocyte, Fatty Change | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Mineralization | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 | 1 1.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 1 2 3 | 3 2.0|
Cyst | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 1 1 1 1 | 5 1.0|
Nephropathy | 1 1 1 | 3 1.0|
Renal Tubule, Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 2| 8| 0| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 4| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 1 | 13 1.1|
Necrosis | 1 1 1 1 | 4 1.0|
Hepatocyte, Fatty Change | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 | 4 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 2| 8| 0| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 4| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Angiectasis | 2 | 1 2.0|
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 2 2 1 | 4 1.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Cyst | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 2| 8| 0| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 3| 6| 3| 4| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 1 1 1 1 | 5 1.0|
Cyst | 1 | 1 1.0|
Nephropathy | 1 1 1 | 3 1.0|
Renal Tubule, Degeneration | 1 | 1 1.0|
Renal Tubule, Hypertrophy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Perforation | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 2 1 1 1 1 1 1 1 | 13 1.1|
Necrosis | 1 | 1 1.0|
Hepatocyte, Fatty Change | 1 1 1 1 1 1 2 | 7 1.1|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Cyst | 1 1 1 2 | 4 1.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 2 1 1 1 | 13 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 3 3 | 3 2.7|
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 1 1 1 | 4 1.0|
Cyst | 1 1 | 2 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 | 1 1.0|
Renal Tubule, Hypertrophy | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 1 1 1 1 1 | 6 1.0|
Necrosis | 1 | 1 1.0|
Hepatocyte, Fatty Change | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy | 1 1 1 2 1 2 | 6 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + | 14 |
Atrophy | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 4| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| | |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Cyst | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 1 2 | 3 1.3|
Nephropathy | 1 1 | 2 1.0|
Renal Tubule, Dilatation | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation | 1 1 1 1 1 1 1 | 7 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 2 1 1 1 1 1 1 | 8 1.1|
Subcapsular, Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration | 4 2 2 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Plasma Cell | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Cyst | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Edema | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 | 1 1.0|
Hydronephrosis | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0|
Artery, Inflammation | 1 | 1 1.0|
Renal Tubule, Dilatation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 1| 8| 8| 8| 4| 1| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Necrosis | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 1| 8| 8| 8| 4| 1| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Cyst | 2 | 1 2.0|
Duct, Ectasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 3 2 | 3 2.7|
Cyst | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 1| 8| 8| 8| 4| 1| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 | 3 1.0|
Renal Tubule, Dilatation | 1 1 1 1 1 | 5 1.0|
Renal Tubule, Hypertrophy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 1 1 1 1 1 1 | 7 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 2 | 2 2.5|
Cyst | 1 1 1 1 1 1 1 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 97013-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:48:22
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Casts Protein | 1 3 1 1 1 1 | 6 1.3|
Nephropathy | 1 1 1 1 | 4 1.0|
Renal Tubule, Degeneration | 1 1 1 1 | 4 1.0|
Renal Tubule, Dilatation | 1 1 1 1 | 4 1.0|
Renal Tubule, Hypertrophy | 1 | 1 1.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
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