TDMS Study 97013-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 06/11/04
EXPERIMENT: 97013 TEST: 08 TIME: 10:50:24
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: GAVAGE NTP C#: 97013G
PATHOLOGIST: MISSING CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 25 MG/KG
INCLUDE 004 25 MG/KG
INCLUDE 005 50 MG/KG
INCLUDE 006 50 MG/KG
INCLUDE 007 100 MG/KG
INCLUDE 008 100 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 06/11/04
EXPERIMENT: 97013 TEST: 08 TIME: 10:50:24
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: GAVAGE NTP C#: 97013G
PATHOLOGIST: MISSING CAS: 75-27-4
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 182 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 1 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 98 |
| CENSORED DEATHS |
| 41 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 143 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 113 113 142 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 182 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 182 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 182 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 92.9 92.9 92.9 92.9 92.9 |
| | |
| | |
|25 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 86.7 80.0 80.0 80.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 25 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 92.9% 93.3% 80.0% 100.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.761N P=1.000N P=0.678 P=0.972N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 98.0 143.0 122.7 . |
|NATURAL DEATHS (C) | ( . ) ( . ) ( 9.7) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 167.0 179.4 170.1 182.0 |
|(STANDARD ERROR) | (10.6) ( 2.6) ( 6.6) ( 0.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 1 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 160 161 168 |
| CENSORED DEATHS |
| 41 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 143 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 104 126 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 1 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 127 |
| CENSORED DEATHS |
| 41 |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 183 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 78.6 |
| | |
| | |
|25 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 93.3 86.7 86.7 86.7 86.7 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 100.0 92.9 92.9 92.9 92.9 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 25 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.6% 93.3% 86.7% 92.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.587N P=0.565N P=0.987N P=0.616N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 163.0 143.0 115.0 127.0 |
|NATURAL DEATHS (C) | ( 2.5) ( . ) (11.0) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 169.5 180.3 173.9 169.8 |
|(STANDARD ERROR) | ( 9.4) ( 2.7) ( 6.3) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
25 MG/KG = 2
50 MG/KG = 3
100 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 3 2 4
|
|
|
98 +
|
|
|
96 +
|
|
|
P 94 +
E | 2 2
R | 1 1
C |
E 92 +
N |
T |
|
S 90 +
U |
R |
V |
I 88 +
V |
A |
L | 3 3
86 +
|
|
|
84 +
|
|
|
82 +
|
|
|
80 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0.0 2.5 5.0 7.5 10.0 12.5 15.0 17.5 20.0 22.5 25.0 27.5
WEEK
NOTE: 3 obs hidden.
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
25 MG/KG = 2
50 MG/KG = 3
100 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 + 1 3 4 2 1
|
|
|
97.5 +
|
|
|
95.0 +
|
P |
E | 3 3 4 2 2
R 92.5 +
C |
E |
N |
T 90.0 +
|
S |
U |
R 87.5 +
V | 3 3
I |
V | 1 1
A 85.0 +
L |
|
|
82.5 +
|
|
|
80.0 +
|
| 1 1
|
77.5 +
|
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
WEEK
NOTE: 4 obs hidden.