TDMS Study 97013-08 Pathology Tables
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 25 MG/KG
Include 006 50 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 25 MG/KG
Include 005 50 MG/KG
Include 007 100 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Dosing Accident 1 1
Natural Death 2 1 2
Survivors
Terminal Sacrifice 11 14 13 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1) (1)
Perforation 1 1
Liver (15) (15) (15) (15)
Basophilic Focus 1
Cyst 1 [2.0]
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0]
Hemorrhage 1 [2.0]
Hepatodiaphragmatic Nodule 1
Inflammation 11 [1.0] 13 [1.0] 13 [1.1] 13 [1.1]
Necrosis 1 [1.0] 4 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 5 [1.0] 8 [1.0] 7 [1.1]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.0] 4 [1.3] 3 [1.0]
Salivary Glands (1) (1)
Atrophy 1 [2.0]
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 [1.0]
Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Mineralization 1 [1.0]
Subcapsular, Hyperplasia 7 [1.0] 10 [1.0] 8 [1.0] 6 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (1)
Cyst 1 [1.0]
Pituitary Gland (15) (15) (15) (15)
Angiectasis 1 [2.0]
Cyst 1 [1.0] 1 [1.0] 2 [1.0]
Thyroid Gland (15) (15) (15) (15)
Cyst 2 [1.0] 2 [1.0] 3 [1.3] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Atrophy 1 [2.0]
Cyst 4 [1.3] 2 [1.0] 4 [1.5] 4 [1.3]
Uterus (15) (15) (15) (15)
Atrophy 1 [2.0]
Inflammation 1 [1.0]
Endometrium, Hyperplasia, Cystic 12 [1.0] 9 [1.0] 12 [1.0] 13 [1.1]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (14) (15) (15) (15)
Hyperplasia 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [2.0] 1 [1.0]
Lymph Node, Mesenteric (14) (15) (15) (15)
Atrophy 1 [3.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0] 1 [1.0]
Lymphoid Follicle, Atrophy 3 [1.7] 1 [2.0]
Thymus (13) (15) (15) (15)
Atrophy 2 [3.0] 3 [2.0] 1 [2.0] 3 [2.7]
Cyst 2 [1.0] 5 [1.0] 5 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 2 [1.0]
Thrombosis 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 4 [1.0] 5 [1.0] 5 [1.0] 4 [1.0]
Cyst 1 [1.0] 2 [1.0]
Mineralization 1 [1.0]
Nephropathy 1 [1.0] 3 [1.0] 3 [1.0] 1 [1.0]
Renal Tubule, Degeneration 1 [1.0]
Renal Tubule, Dilatation 1 [1.0]
Renal Tubule, Hypertrophy 1 [1.0] 1 [1.0] 1 [1.0] 8 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Dosing Accident 1
Moribund Sacrifice 1 1 3
Survivors
Terminal Sacrifice 13 14 12 14
Natural Death 1
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Inflammation 1 [2.0]
Liver (15) (15) (15) (15)
Cyst 1 [2.0]
Hematopoietic Cell Proliferation 1 [2.0]
Inflammation 6 [1.0] 7 [1.0] 9 [1.0] 8 [1.0]
Necrosis 1 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 3 [1.3] 1 [1.0] 3 [1.0] 3 [1.0]
Mesentery (1) (1)
Fat, Necrosis 1 [4.0] 1 [3.0]
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 [1.0]
Tooth (3) (2) (3) (3)
Inflammation 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 6 [1.3] 8 [1.1] 5 [1.0] 7 [1.0]
Subcapsular, Hyperplasia 2 [1.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 2 [1.0] 2 [1.5] 1 [2.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (15) (15) (15) (15)
Cyst 2 [1.0] 2 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Inflammation 1 [1.0]
Preputial Gland (2)
Cyst 1 [2.0]
Duct, Ectasia 1 [2.0]
Testes (15) (15) (15) (15)
Germinal Epithelium, Degeneration 1 [2.0] 4 [2.5] 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Atrophy 1 [2.0]
Hyperplasia 1 [1.0] 2 [1.0]
Infiltration Cellular, Plasma Cell 2 [2.0]
Lymph Node, Mesenteric (15) (14) (15) (15)
Atrophy 1 [3.0] 1 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 1 [2.0] 2 [1.0]
Lymphoid Follicle, Atrophy 1 [2.0] 1 [2.0]
Thymus (14) (15) (15) (15)
Atrophy 2 [2.0] 1 [2.0] 3 [2.7] 2 [2.5]
Cyst 7 [1.0] 5 [1.0] 4 [1.0] 8 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:49:14
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Edema 1 [2.0]
Inflammation 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 [1.3] 6 [1.3]
Cyst 1 [1.0]
Hydronephrosis 1 [1.0]
Nephropathy 2 [1.0] 8 [1.0] 3 [1.0] 4 [1.0]
Artery, Inflammation 1 [1.0]
Renal Tubule, Degeneration 4 [1.0]
Renal Tubule, Dilatation 2 [1.0] 1 [1.0] 5 [1.0] 4 [1.0]
Renal Tubule, Hypertrophy 4 [1.0] 1 [1.0]
Renal Tubule, Necrosis 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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