TDMS Study 97013-09 Pathology Tables
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 MG/L
Include 002 0 MG/L
Include 003 80 MG/L
Include 004 80 MG/L
Include 005 400 MG/L
Include 006 400 MG/L
Include 007 800 MG/L
Include 008 800 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 3 5 5 3
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 10 9 10 12
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 1 (7%)
Inflammation, Chronic Active 11 (73%) 9 (60%) 10 (67%) 12 (80%)
Necrosis 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 5 (33%) 5 (33%) 5 (33%)
Mesentery (1)
Fat, Congestion 1 (100%)
Fat, Hemorrhage 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 4 (27%) 3 (20%) 3 (20%) 7 (47%)
Epithelium, Hyperplasia 5 (33%) 3 (20%) 3 (20%) 8 (53%)
Tooth (1) (3) (2) (4)
Inflammation, Chronic Active 1 (33%)
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CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation, Chronic 1 (100%)
Necrosis, Fibrinoid 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Mineralization 1 (7%)
Necrosis 1 (7%)
Subcapsular, Hyperplasia 4 (27%) 6 (40%) 2 (13%) 2 (13%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 (7%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hypertrophy 6 (40%)
Thyroid Gland (15) (13) (13) (15)
Infiltration Cellular, Lymphocyte 5 (38%) 11 (73%)
Inflammation, Chronic Active 1 (7%)
Follicle, Depletion Secretory 7 (47%) 7 (54%) 11 (85%) 14 (93%)
Follicular Cell, Hypertrophy 2 (13%) 2 (15%) 11 (85%) 13 (87%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (14) (15)
Cyst 1 (7%) 1 (7%)
Mineralization 1 (7%)
Pigmentation, Hemosiderin 1 (7%) 1 (7%)
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 4 (27%) 7 (47%) 6 (40%) 3 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%)
Hyperplasia, Lymphoid 4 (27%) 2 (13%) 5 (33%)
Necrosis, Lymphoid 1 (7%)
Lymph Node, Mesenteric (15) (15) (14) (14)
Hyperplasia, Lymphoid 1 (7%)
Necrosis, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 1 (7%) 2 (13%)
Hematopoietic Cell Proliferation 2 (13%) 3 (20%) 1 (7%) 4 (27%)
Necrosis 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 3 (20%) 3 (20%) 3 (20%) 4 (27%)
Cyst 1 (7%)
Thymocyte, Necrosis 2 (13%) 2 (13%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (5) (2) (7)
Epidermis, Hyperkeratosis 2 (29%)
Epidermis, Hyperplasia, Focal 2 (29%)
Subcutaneous Tissue, Edema 1 (20%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Hemorrhage 1 (7%)
Inflammation, Chronic Active 3 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 (7%)
Nephropathy 2 (13%) 2 (13%) 10 (67%) 13 (87%)
Artery, Inflammation, Chronic 2 (13%)
Renal Tubule, Degeneration 2 (13%) 8 (53%)
Renal Tubule, Dilatation 1 (7%) 2 (13%) 1 (7%)
Renal Tubule, Hypertrophy 1 (7%) 5 (33%) 12 (80%)
Renal Tubule, Necrosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 2 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 13 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 9 (60%) 4 (27%) 10 (67%) 7 (47%)
Necrosis 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 7 (47%) 4 (27%)
Mesentery (1) (1)
Fat, Fibrosis 1 (100%)
Fat, Inflammation, Chronic 1 (100%)
Fat, Necrosis 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 (7%) 1 (7%) 2 (13%)
Epithelium, Hyperplasia 1 (7%) 1 (7%) 2 (13%) 2 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 4 (27%) 6 (40%) 6 (40%) 4 (27%)
Subcapsular, Hyperplasia 1 (7%) 1 (7%) 1 (7%)
Parathyroid Gland (1) (2)
Cyst 1 (100%) 2 (100%)
Pituitary Gland (15) (14) (15) (15)
Pars Distalis, Cyst 4 (27%)
Thyroid Gland (15) (14) (15) (15)
Infiltration Cellular, Lymphocyte 1 (7%) 1 (7%) 2 (13%)
Follicle, Depletion Secretory 4 (27%) 6 (43%) 15 (100%) 15 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hypertrophy 1 (7%) 2 (14%) 12 (80%) 15 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 (13%) 2 (13%)
Preputial Gland (1) (1)
Duct, Ectasia 1 (100%) 1 (100%)
Testes (15) (15) (15) (15)
Cyst 3 (20%)
Germinal Epithelium, Degeneration 1 (7%) 3 (20%) 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Necrosis, Lymphoid 1 (100%)
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 3 (20%) 1 (7%) 3 (20%) 1 (7%)
Necrosis, Lymphoid 1 (7%)
Lymph Node, Mesenteric (15) (15) (15) (15)
Necrosis, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 3 (20%)
Lymphoid Follicle, Necrosis, Lymphoid 1 (7%)
Thymus (15) (15) (14) (15)
Atrophy 2 (13%) 1 (7%) 1 (7%) 2 (13%)
Cyst 2 (13%)
Ectopic Parathyroid Gland 1 (7%)
Thymocyte, Necrosis 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (2) (4) (3)
Epidermis, Hyperkeratosis 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:02:42
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia, Focal 1 (25%) 2 (67%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 (7%)
Nephropathy 1 (7%) 7 (47%) 10 (67%) 14 (93%)
Renal Tubule, Degeneration 10 (67%)
Renal Tubule, Dilatation 1 (7%)
Renal Tubule, Hypertrophy 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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