TDMS Study 97013-09 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 09 TIME: 11:08:07
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013A
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/L
INCLUDE 002 0 MG/L
INCLUDE 003 80 MG/L
INCLUDE 004 80 MG/L
INCLUDE 005 400 MG/L
INCLUDE 006 400 MG/L
INCLUDE 007 800 MG/L
INCLUDE 008 800 MG/L
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 09 TIME: 11:08:07
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013A
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 29 171 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 154 182 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 144 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 800 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 156 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 183 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 183 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 93.3 93.3 93.3 93.3 93.3 93.3 93.3 93.3 86.7 |
| | |
| | |
|80 MG/L | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 86.7 |
| | |
| | |
|400 MG/L | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 93.3 |
| | |
| | |
|800 MG/L | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.7% 86.7% 93.3% 93.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.620N P=1.000N P=0.984N P=0.984N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 100.0 168.0 144.0 156.0 |
|NATURAL DEATHS (C) | (71.0) (14.0) ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 171.9 181.0 180.4 181.2 |
|(STANDARD ERROR) | (10.2) ( 1.9) ( 2.6) ( 1.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 184 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 28 49 123 171 177 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 49 51 91 100 140 144 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 28 92 153 161 181 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 184 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 800 MG/L |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 9 28 142 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 184 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 19 38 57 76 95 114 133 152 171 184 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 93.3 86.7 86.7 86.7 86.7 80.0 80.0 80.0 66.7 |
| | |
| | |
|80 MG/L | 100.0 100.0 86.7 86.7 80.0 73.3 73.3 60.0 60.0 60.0 |
| | |
| | |
|400 MG/L | 100.0 93.3 93.3 93.3 86.7 86.7 86.7 86.7 73.3 66.7 |
| | |
| | |
|800 MG/L | 93.3 86.7 86.7 86.7 86.7 86.7 86.7 80.0 80.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.7% 60.0% 66.7% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.414N P=0.905 P=1.000N P=0.728N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 109.6 95.8 123.0 59.7 |
|NATURAL DEATHS (C) | (30.7) (16.8) (28.0) (41.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 159.2 148.7 163.7 159.1 |
|(STANDARD ERROR) | (13.3) (13.2) (11.6) (15.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
80 MG/L = 2
400 MG/L = 3
800 MG/L = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 5 obs hidden.)
P |
E |
R 100.00 + 1 1 3 2 4
C |
E |
N |
T 93.33 + 1 3 2 4 1 2 3
|
S |
U |
R 86.67 + 1 2 1
V |
I ---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
V 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
A
WEEK
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
80 MG/L = 2
400 MG/L = 3
800 MG/L = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 + 1 4 1 2
|
|
|
P 93.33 + 4 1 1 2 3
E |
R |
C |
E 86.67 + 4 1 2 2 3 1 4 3
N |
T |
|
S 80.00 + 2 2 1 4 3 3 1 4
U |
R |
V |
I 73.33 + 2 2 3 1 1
V |
A |
L |
66.67 + 2 2 1 1
|
|
|
60.00 + 2 2
|
---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+---+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
WEEK
NOTE: 10 obs hidden.