TDMS Study 97013-09 Pathology Tables
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 MG/L
Include 002 0 MG/L
Include 003 80 MG/L
Include 004 80 MG/L
Include 005 400 MG/L
Include 006 400 MG/L
Include 007 800 MG/L
Include 008 800 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 3 5 5 3
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 10 9 10 12
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0]
Inflammation, Chronic Active 11 [1.1] 9 [1.4] 10 [1.2] 12 [1.1]
Necrosis 1 [2.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 5 [1.8] 5 [1.0] 5 [1.4]
Mesentery (1)
Fat, Congestion 1 [3.0]
Fat, Hemorrhage 1 [2.0]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 4 [1.3] 3 [1.0] 3 [1.3] 7 [1.3]
Epithelium, Hyperplasia 5 [2.0] 3 [1.3] 3 [1.3] 8 [1.9]
Tooth (1) (3) (2) (4)
Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation, Chronic 1 [4.0]
Necrosis, Fibrinoid 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Mineralization 1 [2.0]
Necrosis 1 [2.0]
Subcapsular, Hyperplasia 4 [1.0] 6 [1.2] 2 [1.0] 2 [1.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hypertrophy 6 [2.2]
Thyroid Gland (15) (13) (13) (15)
Infiltration Cellular, Lymphocyte 5 [1.0] 11 [1.5]
Inflammation, Chronic Active 1 [1.0]
Follicle, Depletion Secretory 7 [1.1] 7 [1.6] 11 [1.8] 14 [3.1]
Follicular Cell, Hypertrophy 2 [1.0] 2 [1.0] 11 [1.9] 13 [3.2]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (14) (15)
Cyst 1 [2.0] 1 [2.0]
Mineralization 1 [2.0]
Pigmentation, Hemosiderin 1 [2.0] 1 [2.0]
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 4 [1.5] 7 [1.1] 6 [1.3] 3 [1.7]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [2.0]
Hyperplasia, Lymphoid 4 [2.0] 2 [3.0] 5 [2.8]
Necrosis, Lymphoid 1 [1.0]
Lymph Node, Mesenteric (15) (15) (14) (14)
Hyperplasia, Lymphoid 1 [3.0]
Necrosis, Lymphoid 1 [2.0]
Spleen (15) (15) (15) (15)
Atrophy 1 [2.0] 1 [3.0] 1 [3.0] 2 [3.0]
Hematopoietic Cell Proliferation 2 [2.0] 3 [2.0] 1 [2.0] 4 [2.5]
Necrosis 1 [3.0]
Thymus (15) (15) (15) (15)
Atrophy 3 [2.7] 3 [3.0] 3 [3.0] 4 [2.3]
Cyst 1 [1.0]
Thymocyte, Necrosis 2 [4.0] 2 [3.5]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (5) (2) (7)
Epidermis, Hyperkeratosis 2 [2.0]
Epidermis, Hyperplasia, Focal 2 [3.0]
Subcutaneous Tissue, Edema 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Hemorrhage 1 [3.0]
Inflammation, Chronic Active 3 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 [3.0]
Nephropathy 2 [1.0] 2 [1.0] 10 [1.0] 13 [1.8]
Artery, Inflammation, Chronic 2 [1.5]
Renal Tubule, Degeneration 2 [1.0] 8 [1.9]
Renal Tubule, Dilatation 1 [1.0] 2 [1.5] 1 [1.0]
Renal Tubule, Hypertrophy 1 [1.0] 5 [1.0] 12 [1.8]
Renal Tubule, Necrosis 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 2 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 13 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 9 [1.0] 4 [1.0] 10 [1.0] 7 [1.0]
Necrosis 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.0] 4 [1.0] 7 [1.0] 4 [1.0]
Mesentery (1) (1)
Fat, Fibrosis 1 [2.0]
Fat, Inflammation, Chronic 1 [3.0]
Fat, Necrosis 1 [4.0]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 [1.0] 1 [2.0] 2 [1.5]
Epithelium, Hyperplasia 1 [1.0] 1 [2.0] 2 [2.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 4 [1.3] 6 [1.5] 6 [1.3] 4 [1.0]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Parathyroid Gland (1) (2)
Cyst 1 [1.0] 2 [2.0]
Pituitary Gland (15) (14) (15) (15)
Pars Distalis, Cyst 4 [1.0]
Thyroid Gland (15) (14) (15) (15)
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [1.0] 2 [1.0]
Follicle, Depletion Secretory 4 [1.0] 6 [1.0] 15 [1.1] 15 [1.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hypertrophy 1 [2.0] 2 [1.5] 12 [1.6] 15 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 [4.0] 2 [4.0]
Preputial Gland (1) (1)
Duct, Ectasia 1 [2.0] 1 [2.0]
Testes (15) (15) (15) (15)
Cyst 3 [2.0]
Germinal Epithelium, Degeneration 1 [1.0] 3 [2.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Necrosis, Lymphoid 1 [2.0]
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 3 [2.3] 1 [2.0] 3 [3.0] 1 [3.0]
Necrosis, Lymphoid 1 [2.0]
Lymph Node, Mesenteric (15) (15) (15) (15)
Necrosis, Lymphoid 1 [3.0]
Spleen (15) (15) (15) (15)
Atrophy 1 [2.0] 1 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0] 3 [2.0]
Lymphoid Follicle, Necrosis, Lymphoid 1 [2.0]
Thymus (15) (15) (14) (15)
Atrophy 2 [2.0] 1 [3.0] 1 [3.0] 2 [3.0]
Cyst 2 [1.0]
Ectopic Parathyroid Gland 1 [2.0]
Thymocyte, Necrosis 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (2) (4) (3)
Epidermis, Hyperkeratosis 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 11:10:54
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia, Focal 1 [3.0] 2 [2.5]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 [1.0]
Nephropathy 1 [1.0] 7 [1.0] 10 [1.0] 14 [1.6]
Renal Tubule, Degeneration 10 [1.3]
Renal Tubule, Dilatation 1 [2.0]
Renal Tubule, Hypertrophy 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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