TDMS Study 97013-11 Pathology Tables
NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 1 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION TIME: 10:44:32 EIS REPORT 37 FACILITY: Battelle Columbus Laboratory NTP C#: 97013B CONTRACT NUMBER: N01-ES-65406 CAS NUMBER: 7789-38-0 ANIMAL SUPPLIER: TACONIC FARMS CAGE RANGE: ALL DATE RANGE: ALL REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 2 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 2 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: 0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 3 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 4 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: 64 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 4 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 6 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: 128 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 5 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 8 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: 256 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 6 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 10 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: TPA PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 536 536 64 12/31/99 71 01/07/00 2/11 Papilloma Site Of Application Small 20 64 12/31/99 71 01/07/00 2/11 Papilloma Site Of Application Medium 4 REMOVED ** CID 536 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 537 537 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 15 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 16 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 8 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 9 REMOVED ** CID 537 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 538 538 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 10 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 15 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 19 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 6 REMOVED ** CID 538 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 539 539 64 12/31/99 71 01/07/00 2/12 Papilloma Site Of Application Small 12 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 20 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 5 REMOVED ** CID 539 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 540 540 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 20 64 12/31/99 71 01/07/00 2/12 Papilloma Site Of Application Small 9 REMOVED ** CID 540 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 541 541 64 12/31/99 64 12/31/99 1/18 Papilloma Site Of Application Small 10 71 01/07/00 71 01/07/00 1/18 Papilloma Site Of Application Small 15 99 02/04/00 106 02/11/00 2/18 Papilloma Site Of Application Small 2 120 02/25/00 120 02/25/00 1/18 Papilloma Site Of Application Small 20 85 01/21/00 92 01/28/00 2/18 Papilloma Site Of Application Small 5 113 02/18/00 113 02/18/00 1/18 Papilloma Site Of Application Small 6 REMOVED ** CID 541 ** REASON - Other NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 7 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 10 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: TPA PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 541 541 120 02/25/00 Papilloma Site Of Application Small 20 542 542 57 12/24/99 57 12/24/99 1/11 Papilloma Site Of Application Small 12 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 15 50 12/17/99 50 12/17/99 1/11 Papilloma Site Of Application Medium 2 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 57 12/24/99 57 12/24/99 1/11 Papilloma Site Of Application Medium 3 50 12/17/99 50 12/17/99 1/11 Papilloma Site Of Application Small 6 REMOVED ** CID 542 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 543 543 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 16 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 543 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 544 544 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Small 15 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Medium 7 REMOVED ** CID 544 ** REASON - Other 54 12/21/99 Papilloma Site Of Application Small 20 545 545 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 19 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 545 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 546 546 50 12/17/99 64 12/31/99 3/11 Papilloma Site Of Application Small 13 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 546 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 547 547 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 12 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 547 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 8 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 10 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: FEMALE TRT: TPA PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 548 548 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 13 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 15 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 17 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 5 REMOVED ** CID 548 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 549 549 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Small 17 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Medium 2 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Large 2 REMOVED ** CID 549 ** REASON - Other 54 12/21/99 Papilloma Site Of Application Small 20 550 550 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 15 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 16 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 18 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Large 6 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 8 REMOVED ** CID 550 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 9 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 1 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: 0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 10 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 3 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: 64 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 11 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 5 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: 128 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 12 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 7 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: 256 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 13 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 9 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: TPA PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 521 521 50 12/17/99 57 12/24/99 2/12 Papilloma Site Of Application Medium 2 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 20 50 12/17/99 57 12/24/99 2/12 Papilloma Site Of Application Small 3 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 5 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 6 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 8 REMOVED ** CID 521 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 522 522 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Medium 1 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 11 50 12/17/99 71 01/07/00 4/11 Papilloma Site Of Application Large 4 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 4 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Medium 5 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Small 6 REMOVED ** CID 522 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 74 01/10/00 Papilloma Site Of Application Medium 4 523 523 64 12/31/99 64 12/31/99 1/12 Papilloma Site Of Application Small 1 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Small 14 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 4 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 8 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Large 9 REMOVED ** CID 523 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 524 524 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Large 2 50 12/17/99 50 12/17/99 1/8 Papilloma Site Of Application Small 20 REMOVED ** CID 524 ** REASON - Other 54 12/21/99 Papilloma Site Of Application Small 20 525 525 99 02/04/00 99 02/04/00 1/16 Papilloma Site Of Application Small 14 106 02/11/00 106 02/11/00 1/16 Papilloma Site Of Application Small 15 71 01/07/00 71 01/07/00 1/16 Papilloma Site Of Application Medium 2 85 01/21/00 85 01/21/00 1/16 Papilloma Site Of Application Small 4 78 01/14/00 78 01/14/00 1/16 Papilloma Site Of Application Large 4 92 01/28/00 99 02/04/00 2/16 Papilloma Site Of Application Medium 5 78 01/14/00 78 01/14/00 1/16 Papilloma Site Of Application Small 5 71 01/07/00 71 01/07/00 1/16 Papilloma Site Of Application Small 6 NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 14 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 9 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: TPA PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS ANIMAL DATA - 525 525 85 01/21/00 85 01/21/00 1/16 Papilloma Site Of Application Large 6 64 12/31/99 64 12/31/99 1/16 Papilloma Site Of Application Small 7 78 01/14/00 85 01/21/00 2/16 Papilloma Site Of Application Medium 7 106 02/11/00 106 02/11/00 1/16 Papilloma Site Of Application Medium 8 REMOVED ** CID 525 ** REASON - Other 109 02/14/00 Papilloma Site Of Application Small 15 109 02/14/00 Papilloma Site Of Application Medium 7 526 526 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Large 3 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 4 50 12/17/99 71 01/07/00 3/11 Papilloma Site Of Application Medium 4 57 12/24/99 57 12/24/99 1/11 Papilloma Site Of Application Medium 8 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Small 9 REMOVED ** CID 526 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 527 527 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 12 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 527 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 528 528 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Large 1 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 10 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Small 11 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 50 12/17/99 57 12/24/99 2/11 Papilloma Site Of Application Medium 3 64 12/31/99 71 01/07/00 2/11 Papilloma Site Of Application Medium 6 REMOVED ** CID 528 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 529 529 50 12/17/99 57 12/24/99 2/12 Papilloma Site Of Application Large 1 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 13 64 12/31/99 71 01/07/00 2/12 Papilloma Site Of Application Medium 3 50 12/17/99 50 12/17/99 1/12 Papilloma Site Of Application Small 6 64 12/31/99 78 01/14/00 3/12 Papilloma Site Of Application Small 8 57 12/24/99 57 12/24/99 1/12 Papilloma Site Of Application Small 9 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Large 9 REMOVED ** CID 529 ** REASON - Other NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 15 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 9 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: TPA PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 529 529 83 01/19/00 Papilloma Site Of Application Small 20 530 530 64 12/31/99 71 01/07/00 2/11 Papilloma Site Of Application Small 20 REMOVED ** CID 530 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 531 531 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 16 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 531 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 532 532 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 14 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 REMOVED ** CID 532 ** REASON - Other 74 01/10/00 Papilloma Site Of Application Small 20 533 533 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Large 10 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 10 50 12/17/99 57 12/24/99 2/12 Papilloma Site Of Application Medium 2 50 12/17/99 71 01/07/00 4/12 Papilloma Site Of Application Large 3 64 12/31/99 71 01/07/00 2/12 Papilloma Site Of Application Medium 6 50 12/17/99 71 01/07/00 3/12 Papilloma Site Of Application Small 6 REMOVED ** CID 533 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 534 534 64 12/31/99 78 01/14/00 2/12 Papilloma Site Of Application Small 10 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Medium 13 71 01/07/00 71 01/07/00 1/12 Papilloma Site Of Application Small 15 78 01/14/00 78 01/14/00 1/12 Papilloma Site Of Application Large 6 REMOVED ** CID 534 ** REASON - Other 83 01/19/00 Papilloma Site Of Application Small 20 535 535 71 01/07/00 71 01/07/00 1/11 Papilloma Site Of Application Small 20 64 12/31/99 64 12/31/99 1/11 Papilloma Site Of Application Small 5 REMOVED ** CID 535 ** REASON - Other NTP EXP/TEST: 97013-11 WATER DISINFECTION MODEL (SODIUM BROMATE) PAGE: 16 TEST TYPE: SUBCHRON 26-WEEK DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 06/21/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 10:44:32 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 9 ROOM/AREA: 218 FIRST DOSE: 10/29/99 SEX: MALE TRT: TPA PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 535 535 74 01/10/00 Papilloma Site Of Application Small 20 ----------------------------------- ---------- END-OF-REPORT ---------- -----------------------------------