TDMS Study 97013-11 Pathology Tables
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 64 MG/KG
Include 004 64 MG/KG
Include 005 128 MG/KG
Include 006 128 MG/KG
Include 007 256 MG/KG
Include 008 256 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 4 1 3
Natural Death 2 1 3 1
Survivors
Terminal Sacrifice 11 10 11 11
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (1) (2) (1)
Anus, Hyperplasia 1 (50%)
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 2 (13%) 2 (13%) 3 (20%)
Inflammation, Chronic Active 13 (87%) 12 (80%) 12 (80%) 12 (80%)
Thrombosis 1 (7%)
Hepatocyte, Degeneration 1 (7%)
Hepatocyte, Fatty Change 1 (7%)
Hepatocyte, Necrosis 1 (7%) 2 (13%) 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 4 (27%) 3 (20%) 3 (20%)
Salivary Glands (1)
Atrophy 1 (100%)
Inflammation, Chronic Active 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 (7%) 2 (13%) 1 (7%) 1 (7%)
Epithelium, Hyperplasia 2 (13%) 2 (13%) 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 3 (20%) 3 (20%) 1 (7%) 1 (7%)
Subcapsular, Hyperplasia 4 (27%) 3 (20%) 5 (33%) 3 (20%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 2 (13%) 1 (7%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Cyst 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%)
Infiltration Cellular, Lymphocyte 6 (40%) 3 (20%) 12 (80%)
Follicle, Cyst 1 (7%) 1 (7%)
Follicle, Depletion Secretory 6 (40%) 11 (73%) 13 (87%) 14 (93%)
Follicular Cell, Hypertrophy 1 (7%) 9 (60%) 12 (80%) 13 (87%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Atrophy 1 (7%)
Cyst 1 (7%) 3 (20%)
Hemorrhage 1 (7%)
Pigmentation 1 (7%)
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 11 (73%) 9 (60%) 10 (67%) 10 (67%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (2)
Mediastinal, Hyperplasia, Lymphoid 1 (50%)
Lymph Node, Mandibular (15) (14) (14) (15)
Hyperplasia, Lymphoid 4 (27%) 2 (14%) 2 (14%) 3 (20%)
Lymph Node, Mesenteric (14) (14) (13) (15)
Hyperplasia, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 1 (7%)
Hematopoietic Cell Proliferation 3 (20%) 5 (33%) 9 (60%) 10 (67%)
Thymus (15) (14) (15) (15)
Atrophy 1 (7%) 3 (21%) 4 (27%) 2 (13%)
Cyst 2 (13%) 4 (29%) 2 (13%) 3 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (15) (15) (15) (15)
Hyperkeratosis 1 (7%)
Inflammation, Chronic Active 1 (7%) 1 (7%) 1 (7%)
Inflammation, Suppurative 1 (7%)
Ulcer 1 (7%)
Epidermis, Hyperplasia, Focal 2 (13%) 3 (20%) 3 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1)
Fracture 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 2 (13%)
Thrombosis 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 8 (53%) 7 (47%) 13 (87%) 15 (100%)
Renal Tubule, Dilatation 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 1
Natural Death 1 3 2
Survivors
Terminal Sacrifice 12 11 13 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Inflammation, Chronic Active 10 (67%) 6 (40%) 9 (60%) 11 (73%)
Hepatocyte, Necrosis 1 (7%) 2 (13%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 3 (20%) 6 (40%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperplasia 1 (7%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 (7%)
Hypertrophy 8 (53%) 4 (27%) 1 (7%) 3 (20%)
Subcapsular, Hyperplasia 1 (7%)
Pituitary Gland (15) (14) (15) (15)
Pars Distalis, Cyst 3 (21%) 4 (27%) 3 (20%)
Pars Distalis, Hyperplasia 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 1 (7%)
Follicle, Depletion Secretory 7 (47%) 4 (27%) 5 (33%) 11 (73%)
Follicular Cell, Hypertrophy 7 (47%) 10 (67%) 14 (93%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 1 (7%) 2 (13%)
Testes (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%)
Germinal Epithelium, Degeneration 2 (13%) 2 (13%) 3 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Necrosis, Lymphoid 1 (7%) 1 (7%)
Lymph Node, Mesenteric (15) (15) (15) (15)
Necrosis, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 2 (13%)
Thymus (14) (15) (15) (15)
Atrophy 1 (7%) 4 (27%) 1 (7%) 4 (27%)
Cyst 2 (14%) 2 (13%) 2 (13%) 5 (33%)
Ectopic Parathyroid Gland 1 (7%)
Ectopic Thyroid 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Hyperkeratosis 2 (13%) 3 (20%) 4 (27%)
Hyperkeratosis, Focal 1 (7%)
Inflammation, Chronic Active 1 (7%)
Epidermis, Hyperplasia, Focal 3 (20%) 2 (13%) 3 (20%) 4 (27%)
Site of Application - Epidermis, Hyperplasia,
Focal 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:16:13
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
Pigmentation 1 (7%)
Thrombosis 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
Alveolus, Infiltration Cellular, Histiocyte 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 8 (53%) 8 (53%) 14 (93%) 14 (93%)
Artery, Inflammation, Chronic Active 1 (7%)
Renal Tubule, Dilatation 1 (7%) 2 (13%)
Urethra (1)
Bulbourethral Gland, Cyst 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------