TDMS Study 97013-97 Pathology Tables
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 2 1 1 1
Moribund Sacrifice 1 2
Survivors
Terminal Sacrifice 7 9 9 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (1)
Inflammation, Chronic Active 1 (100%)
Intestine Large, Colon (10) (10) (10) (10)
Inflammation 1 (10%)
Intestine Large, Cecum (10) (10) (10) (10)
Edema 1 (10%)
Inflammation 1 (10%)
Intestine Small, Ileum (10) (10) (10) (10)
Ulcer 1 (10%)
Liver (10) (10) (10) (10)
Cytomegaly 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 3 (30%)
Inflammation 8 (80%) 9 (90%) 10 (100%) 6 (60%)
Necrosis 2 (20%) 2 (20%) 1 (10%) 1 (10%)
Hepatocyte, Fatty Change 2 (20%) 8 (80%) 5 (50%)
Hepatocyte, Vacuolization Cytoplasmic 6 (60%) 9 (90%) 10 (100%) 9 (90%)
Mesentery (1)
Hemorrhage 1 (100%)
Artery, Inflammation 1 (100%)
Artery, Thrombosis 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%) 2 (20%) 4 (40%) 4 (40%)
Epithelium, Hyperplasia 1 (10%) 2 (20%) 4 (40%) 4 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Subcapsular, Hyperplasia 5 (50%) 6 (60%) 4 (40%) 7 (70%)
Islets, Pancreatic (1)
Hyperplasia 1 (100%)
Pituitary Gland (10) (10) (10) (10)
Cyst 2 (20%) 1 (10%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Cyst 2 (20%) 5 (50%) 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Amyloid Deposition 1 (10%)
Atrophy 1 (10%)
Cyst 1 (10%) 3 (30%) 1 (10%)
Inflammation, Suppurative 1 (10%)
Oviduct (1)
Inflammation, Suppurative 1 (100%)
Uterus (10) (10) (10) (10)
Inflammation 1 (10%) 1 (10%)
Inflammation, Granulomatous 1 (10%)
Endometrium, Hyperplasia, Cystic 7 (70%) 10 (100%) 9 (90%) 8 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (9)
Hyperplasia 1 (10%)
Infiltration Cellular, Plasma Cell 2 (20%) 1 (10%) 2 (22%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Ectasia 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 2 (20%) 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (10) (10) (10) (9)
Atrophy 2 (20%) 1 (10%) 4 (44%)
Cyst 3 (30%) 2 (20%) 5 (50%) 3 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1)
Inflammation, Granulomatous 1 (100%)
Skin (6) (5) (7) (7)
Hyperplasia 1 (17%) 3 (60%) 2 (29%)
Epidermis, Hyperplasia, Focal 1 (20%) 1 (14%)
Subcutaneous Tissue, Hemorrhage 1 (14%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 (10%)
Perivascular, Inflammation 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Amyloid Deposition 1 (10%)
Casts Protein 1 (10%) 2 (20%) 6 (60%)
Cyst 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (10%)
Nephropathy 3 (30%) 4 (40%) 5 (50%)
Renal Tubule, Hypertrophy 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 1 4 2
Accidently Killed 1
Dosing Accident 3
Survivors
Terminal Sacrifice 6 6 6 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 1 (10%) 1 (10%)
Inflammation 7 (70%) 6 (60%) 8 (80%) 5 (50%)
Necrosis 2 (20%)
Hepatocyte, Fatty Change 2 (20%)
Hepatocyte, Vacuolization Cytoplasmic 6 (60%) 3 (30%) 7 (70%) 7 (70%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 2 (20%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 2 (20%) 3 (30%) 2 (20%)
Epithelium, Hyperplasia 2 (20%) 3 (30%) 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 7 (70%) 3 (30%) 6 (60%) 7 (70%)
Subcapsular, Hyperplasia 1 (10%) 2 (20%)
Pituitary Gland (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Cyst 2 (20%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Preputial Gland (1)
Inflammation, Suppurative 1 (100%)
Testes (10) (10) (10) (10)
Germinal Epithelium, Degeneration 2 (20%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9) (9) (10)
Hematopoietic Cell Proliferation 1 (10%)
Hyperplasia 1 (10%) 1 (11%) 1 (11%) 1 (10%)
Infiltration Cellular, Plasma Cell 1 (10%) 2 (22%) 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Hyperplasia 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 4 (40%) 2 (20%) 1 (10%)
Thymus (9) (10) (10) (10)
Atrophy 3 (33%) 3 (30%) 3 (30%) 2 (20%)
Cyst 4 (44%) 2 (20%) 2 (20%) 3 (30%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (5) (6) (5) (7)
Hyperplasia 1 (17%) 2 (40%) 4 (57%)
Inflammation 1 (14%)
Subcutaneous Tissue, Fibrosis 1 (14%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:00:46
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 (10%) 1 (10%) 2 (20%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Perivascular, Inflammation 1 (10%) 1 (10%)
Pleura (3)
Inflammation, Suppurative 3 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 3 (30%) 1 (10%) 1 (10%)
Cyst 1 (10%) 2 (20%)
Nephropathy 3 (30%) 4 (40%) 6 (60%) 6 (60%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%)
Renal Tubule, Degeneration 6 (60%)
Renal Tubule, Dilatation 2 (20%) 2 (20%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
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