TDMS Study 97013-97 Pathology Tables
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Natural Death 2 1 1 1
Moribund Sacrifice 1 2
Survivors
Terminal Sacrifice 7 9 9 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Salivary Glands (3)
Duct, Carcinoma 3 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 3 (30%) 1 (10%) 3 (30%) 1 (10%)
Squamous Cell Papilloma, Multiple 1 (10%) 6 (60%) 5 (50%) 9 (90%)
Tooth (4) (3) (3) (2)
Odontogenic Tumor 4 (100%) 3 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Squamous Cell Carcinoma,
Metastatic, Skin 1 (100%)
Lymph Node, Mandibular (10) (10) (10) (9)
Squamous Cell Carcinoma, Metastatic, Skin 1 (11%)
Spleen (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (5) (7) (7)
Squamous Cell Carcinoma 1 (14%)
Squamous Cell Papilloma 3 (50%) 2 (40%) 2 (29%) 3 (43%)
Squamous Cell Papilloma, Multiple 3 (50%) 2 (40%) 4 (57%) 4 (57%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 7 9 10
Total Primary Neoplasms 14 15 17 23
Total Animals with Benign Neoplasms 8 7 9 10
Total Benign Neoplasms 10 11 14 17
Total Animals with Malignant Neoplasms 1 4
Total Malignant Neoplasms 1 4
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 3 3 2
Total Uncertain Neoplasms 4 3 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 1 4 2
Accidently Killed 1
Dosing Accident 3
Survivors
Terminal Sacrifice 6 6 6 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (1) (1) (1) (1)
Anus, Squamous Cell Papilloma 1 (100%)
Liver (10) (10) (10) (10)
Salivary Glands (2) (2) (1)
Duct, Carcinoma 2 (100%) 2 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 1 (10%) 4 (40%) 1 (10%)
Squamous Cell Papilloma, Multiple 6 (60%) 5 (50%) 5 (50%) 5 (50%)
Tooth (4) (2) (4) (4)
Odontogenic Tumor 4 (100%) 2 (100%) 4 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (5) (6) (5) (7)
Squamous Cell Papilloma 1 (20%) 2 (33%) 4 (57%)
Squamous Cell Papilloma, Multiple 4 (80%) 4 (67%) 4 (80%) 2 (29%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 97013-97 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:01:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 7 10 10
Total Primary Neoplasms 19 14 21 18
Total Animals with Benign Neoplasms 8 6 10 7
Total Benign Neoplasms 13 12 14 13
Total Animals with Malignant Neoplasms 2 3 1
Total Malignant Neoplasms 2 3 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 2 4 4
Total Uncertain Neoplasms 4 2 4 4
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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