TDMS Study 97013-99 Pathology Tables
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 4 4 3 4
Natural Death 1 2 1
Survivors
Terminal Sacrifice 5 4 7 5
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 4 (40%) 2 (20%) 1 (10%) 4 (40%)
Inflammation 7 (70%) 6 (60%) 9 (90%) 5 (50%)
Necrosis 1 (10%) 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 4 (40%) 4 (40%) 7 (70%) 6 (60%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperplasia 1 (10%) 1 (10%)
Tooth (4) (4) (4) (3)
Peridontal Tissue, Hyperplasia 1 (25%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Subcapsular, Hyperplasia 7 (70%) 5 (50%) 5 (50%) 7 (70%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Cyst 2 (20%) 3 (30%) 1 (10%) 1 (10%)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 1 (10%) 3 (30%) 1 (10%)
Cyst 1 (10%) 1 (10%) 2 (20%) 1 (10%)
Inflammation 1 (10%)
Inflammation, Suppurative 1 (10%)
Oviduct (1)
Inflammation 1 (100%)
Uterus (10) (10) (10) (10)
Hydrometra 1 (10%)
Inflammation 1 (10%)
Endometrium, Hyperplasia, Cystic 5 (50%) 4 (40%) 5 (50%) 7 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (9)
Hyperplasia 3 (30%) 1 (10%) 1 (11%)
Infiltration Cellular, Plasma Cell 1 (10%)
Lymph Node, Mesenteric (9) (9) (10) (10)
Hyperplasia 1 (11%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 2 (20%) 1 (10%) 2 (20%)
Lymphoid Follicle, Atrophy 1 (10%)
Thymus (10) (10) (10) (10)
Atrophy 2 (20%) 6 (60%) 2 (20%) 2 (20%)
Cyst 3 (30%) 2 (20%) 2 (20%) 3 (30%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperplasia 2 (20%) 1 (10%)
Inflammation, Focal 2 (20%) 1 (10%) 1 (10%)
Control Epidermis, Hyperplasia 2 (20%) 1 (10%)
Epidermis, Hyperplasia, Focal 1 (10%) 1 (10%) 1 (10%) 1 (10%)
Site of Application - Epidermis, Hyperplasia 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Site of Application - Epidermis, Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 (10%)
Alveolar Epithelium, Hyperplasia 2 (20%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (10%)
Perivascular, Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Retina, Degeneration 1 (100%)
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URINARY SYSTEM
Kidney (10) (10) (10) (10)
Accumulation, Hyaline Droplet 1 (10%) 1 (10%)
Casts Protein 2 (20%) 1 (10%) 1 (10%) 1 (10%)
Cyst 1 (10%) 2 (20%)
Hydronephrosis 1 (10%) 1 (10%)
Inflammation 1 (10%)
Mineralization 1 (10%)
Nephropathy 2 (20%) 1 (10%) 4 (40%) 1 (10%)
Artery, Inflammation 1 (10%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%) 3 (30%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 1 1
Natural Death 1 2 1
Survivors
Terminal Sacrifice 6 8 9 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 1 (10%) 1 (10%) 1 (10%)
Inflammation 6 (60%) 3 (30%) 6 (60%) 3 (30%)
Necrosis 1 (10%) 1 (10%) 1 (10%) 1 (10%)
Hepatocyte, Fatty Change 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 6 (60%) 7 (70%) 8 (80%) 7 (70%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%)
Epithelium, Hyperplasia 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 (50%) 3 (30%) 4 (40%) 4 (40%)
Subcapsular, Hyperplasia 1 (10%) 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Cyst 1 (10%) 2 (20%) 1 (10%) 2 (20%)
Thyroid Gland (10) (10) (10) (10)
Cyst 3 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Inflammation 1 (10%)
Testes (10) (10) (10) (10)
Germinal Epithelium, Degeneration 1 (10%) 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia 1 (10%) 1 (10%)
Infiltration Cellular, Plasma Cell 2 (20%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 4 (40%) 2 (20%) 3 (30%) 1 (10%)
Pigmentation 1 (10%)
Lymphoid Follicle, Atrophy 1 (10%)
Thymus (9) (10) (9) (9)
Atrophy 1 (11%) 2 (22%) 1 (11%)
Cyst 4 (44%) 2 (20%) 1 (11%) 3 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperplasia 1 (10%) 1 (10%)
Inflammation 1 (10%)
Inflammation, Focal 1 (10%) 2 (20%) 1 (10%)
Ulcer 1 (10%)
Control Epidermis, Hyperplasia 1 (10%)
Epidermis, Hyperplasia, Focal 1 (10%) 1 (10%)
Site of Application - Dermis, Inflammation 1 (10%)
Site of Application - Epidermis, Hyperplasia 1 (10%) 1 (10%)
Site of Application - Epidermis, Hyperplasia,
Focal 1 (10%)
Site of Application - Epidermis,
Inflammation, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/05/03
Route: SKIN APPLICATION Time: 10:04:18
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 (10%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Perivascular, Inflammation 1 (10%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 (10%) 2 (20%) 4 (40%) 2 (20%)
Cyst 1 (10%) 1 (10%) 2 (20%) 2 (20%)
Hydronephrosis 2 (20%)
Nephropathy 6 (60%) 5 (50%) 3 (30%) 6 (60%)
Artery, Inflammation 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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