TDMS Study 97013-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 11/05/03
EXPERIMENT: 97013 TEST: 99 TIME: 10:08:09
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 97013F
PATHOLOGIST: MISSING CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) DATE: 11/05/03
EXPERIMENT: 97013 TEST: 99 TIME: 10:08:09
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 97013F
PATHOLOGIST: MISSING CAS: 75-27-4
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 153 202 211 233 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 64 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 91 145 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 128 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 260 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 256 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 166 260 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 274 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 90.0 90.0 70.0 60.0 60.0 |
| | |
| | |
|64 MG/KG | 100.0 100.0 100.0 90.0 90.0 80.0 80.0 80.0 80.0 80.0 |
| | |
| | |
|128 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 |
|MG/KG | |
| | |
|256 | 100.0 100.0 100.0 100.0 100.0 100.0 90.0 90.0 90.0 80.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 64 MG/KG 128 256 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 80.0% 90.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.424N P=0.730N P=0.242N P=0.556N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 199.8 118.0 260.0 213.0 |
|NATURAL DEATHS (C) | (16.9) (27.0) ( . ) (47.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 244.3 242.8 272.6 261.8 |
|(STANDARD ERROR) | (13.6) (21.2) ( 1.4) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 51 96 98 117 254 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 64 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 83 94 96 104 190 196 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 128 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 226 229 233 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 256 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 37 99 133 184 217 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 274 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 274 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 90.0 90.0 70.0 60.0 60.0 60.0 60.0 60.0 50.0 |
| | |
| | |
|64 MG/KG | 100.0 100.0 100.0 60.0 60.0 60.0 50.0 40.0 40.0 40.0 |
| | |
| | |
|128 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 70.0 70.0 |
|MG/KG | |
| | |
|256 | 100.0 90.0 90.0 80.0 70.0 70.0 60.0 50.0 50.0 50.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 64 MG/KG 128 256 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 40.0% 70.0% 50.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.849N P=0.879 P=0.472N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 123.2 127.2 229.3 134.0 |
|NATURAL DEATHS (C) | (34.4) (21.0) ( 2.0) (31.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 198.6 185.9 260.6 204.0 |
|(STANDARD ERROR) | (29.9) (26.9) ( 6.8) (27.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
64 MG/KG = 2
128 MG/KG = 3
256 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
P 100 + 1 2 1 4 3
E |
R |
C |
E 90 + 2 2 1 4 1 3 3
N |
T |
|
S 80 + 2 1 1 4 2
U |
R |
V |
I 70 + 1 1
V |
A |
L |
60 + 1 1
|
---+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
WEEK
NOTE: 5 obs hidden.
WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
64 MG/KG = 2
128 MG/KG = 3
256 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
|
|
|
P 90 + 4 1 2 1 4
E |
R |
C |
E 80 + 4 4 3 3
N |
T |
|
S 70 + 1 2 1 4 4 3 3
U |
R |
V |
I 60 + 2 1 4 2 4 1
V |
A |
L |
50 + 4 1 1
|
|
|
40 + 2 2
|
---+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+--
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40
WEEK
NOTE: 6 obs hidden.