TDMS Study 97013-99 Pathology Tables
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 4 4 3 4
Natural Death 1 2 1
Survivors
Terminal Sacrifice 5 4 7 5
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 4 [1.0] 2 [1.0] 1 [1.0] 4 [1.3]
Inflammation 7 [1.1] 6 [1.0] 9 [1.1] 5 [1.0]
Necrosis 1 [1.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 4 [1.3] 4 [1.3] 7 [1.6] 6 [1.2]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperplasia 1 [1.0] 1 [1.0]
Tooth (4) (4) (4) (3)
Peridontal Tissue, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0]
Subcapsular, Hyperplasia 7 [1.0] 5 [1.0] 5 [1.0] 7 [1.0]
Parathyroid Gland (1)
Cyst 1 [1.0]
Pituitary Gland (10) (10) (10) (10)
Cyst 1 [1.0] 1 [1.0] 1 [1.0]
Thyroid Gland (10) (10) (10) (10)
Cyst 2 [1.0] 3 [1.0] 1 [1.0] 1 [1.0]
Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 1 [2.0] 3 [1.3] 1 [2.0]
Cyst 1 [2.0] 1 [1.0] 2 [1.5] 1 [1.0]
Inflammation 1 [3.0]
Inflammation, Suppurative 1 [2.0]
Oviduct (1)
Inflammation 1 [3.0]
Uterus (10) (10) (10) (10)
Hydrometra 1 [2.0]
Inflammation 1 [2.0]
Endometrium, Hyperplasia, Cystic 5 [1.8] 4 [1.5] 5 [1.2] 7 [1.6]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (9)
Hyperplasia 3 [2.0] 1 [1.0] 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [1.0]
Lymph Node, Mesenteric (9) (9) (10) (10)
Hyperplasia 1 [2.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 [1.0] 2 [1.0] 1 [1.0] 2 [1.0]
Lymphoid Follicle, Atrophy 1 [2.0]
Thymus (10) (10) (10) (10)
Atrophy 2 [1.5] 6 [2.2] 2 [2.0] 2 [2.0]
Cyst 3 [1.0] 2 [1.0] 2 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperplasia 2 [2.0] 1 [1.0]
Inflammation, Focal 2 [1.5] 1 [1.0] 1 [1.0]
Control Epidermis, Hyperplasia 2 [2.0] 1 [2.0]
Epidermis, Hyperplasia, Focal 1 [3.0] 1 [2.0] 1 [3.0] 1 [2.0]
Site of Application - Epidermis, Hyperplasia 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Site of Application - Epidermis, Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 [1.0]
Alveolar Epithelium, Hyperplasia 2 [1.5]
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 [2.0]
Perivascular, Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Retina, Degeneration 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Accumulation, Hyaline Droplet 1 [3.0] 1 [1.0]
Casts Protein 2 [1.0] 1 [1.0] 1 [1.0] 1 [2.0]
Cyst 1 [1.0] 2 [1.0]
Hydronephrosis 1 [1.0] 1 [1.0]
Inflammation 1 [1.0]
Mineralization 1 [1.0]
Nephropathy 2 [1.5] 1 [2.0] 4 [1.0] 1 [1.0]
Artery, Inflammation 1 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [1.0] 3 [2.0] 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 1 1
Natural Death 1 2 1
Survivors
Terminal Sacrifice 6 8 9 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Inflammation 6 [1.0] 3 [1.0] 6 [1.0] 3 [1.0]
Necrosis 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.3] 7 [1.3] 8 [1.1] 7 [1.3]
Mesentery (1)
Fat, Necrosis 1 [3.0]
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 [1.0]
Epithelium, Hyperplasia 2 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 [1.0] 3 [1.7] 4 [1.8] 4 [1.0]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0]
Pituitary Gland (10) (10) (10) (10)
Cyst 1 [1.0] 2 [1.0] 1 [1.0] 2 [1.0]
Thyroid Gland (10) (10) (10) (10)
Cyst 3 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Inflammation 1 [1.0]
Testes (10) (10) (10) (10)
Germinal Epithelium, Degeneration 1 [1.0] 2 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia 1 [2.0] 1 [2.0]
Infiltration Cellular, Plasma Cell 2 [1.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 4 [1.3] 2 [1.0] 3 [1.0] 1 [1.0]
Pigmentation 1 [1.0]
Lymphoid Follicle, Atrophy 1 [2.0]
Thymus (9) (10) (9) (9)
Atrophy 1 [3.0] 2 [2.0] 1 [3.0]
Cyst 4 [1.0] 2 [1.0] 1 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperplasia 1 [2.0] 1 [1.0]
Inflammation 1 [1.0]
Inflammation, Focal 1 [1.0] 2 [2.0] 1 [1.0]
Ulcer 1 [2.0]
Control Epidermis, Hyperplasia 1 [2.0]
Epidermis, Hyperplasia, Focal 1 [1.0] 1 [2.0]
Site of Application - Dermis, Inflammation 1 [1.0]
Site of Application - Epidermis, Hyperplasia 1 [2.0] 1 [2.0]
Site of Application - Epidermis, Hyperplasia,
Focal 1 [3.0]
Site of Application - Epidermis,
Inflammation, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 11/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:10:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 1 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [1.0]
Perivascular, Inflammation 1 [2.0] 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 [1.0] 2 [1.0] 4 [1.0] 2 [1.0]
Cyst 1 [1.0] 1 [1.0] 2 [1.0] 2 [1.0]
Hydronephrosis 2 [1.5]
Nephropathy 6 [1.0] 5 [1.0] 3 [1.0] 6 [1.0]
Artery, Inflammation 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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