Chlordecone: Target Organs and Levels of Evidence for TR-000
Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0) and Chloroform (CASRN 67-66-3)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Chlordecone (kepone)
143-50-0 | NA | Dosed-Feed
FR: 0,18,26 (AVG), MR: 0,8,24 (AVG), FM: 0,20,40 (AVG), MM: 0,20,23 (AVG) PPM | Gulf South Research Institute |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Liver: CARCINOMA; HYPERPLASIA
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Liver: CARCINOMA; HYPERPLASIA
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Liver: CARCINOMA; HYPERPLASIA
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Liver: CARCINOMA; HYPERPLASIA
|
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Chloroform
67-66-3 | 09/00/1976 | Gavage
MR:0,90,180 FR:0,125,250 (WK 1-22) 0,90,180 (WK23-SAC) FM:0,7,14 MM:0,4,8 MG/KG/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA COMBINED
|
Female Rats: Negative
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | |
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | |
