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https://ntp.niehs.nih.gov/go/13350

Nitrilotriacetic acid (NTA): Target Organs and Levels of Evidence for TR-006

Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O)

Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid (NTA)
139-13-9 		03/25/1977 Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000,7500,15000 PPM/50 PER GROUP		 Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
  • Ureter: (ADENOMA OR PAPILLOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOCARCINOMA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOCARCINOMA


Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid trisodium monohydrate
18662-53-8 		03/25/1977 Dosed-Feed
0,200,2000,20000 PPM/48 PER GROUP		 SRI International

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA
  • Kidney Tubular Cell: ADENOCARCINOMA OR CARCINOMA
  • Ureter: (TRANSITIONAL CELL CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
  • Ureter: (TRANSITIONAL CELL CARCINOMA)
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)


Chemical (Study Title)
CASRN 		Peer Review Date Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid trisodium monohydrate
18662-53-8 		03/25/1977 Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000 PPM/50 PER GROUP		 Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: PAPILLOMA
  • Kidney Tubular Cell: ADENOCARCINOMA
Female Rats: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
Male Mice: Negative
Female Mice: Negative