Nitrilotriacetic acid (NTA): Target Organs and Levels of Evidence for TR-006
Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Nitrilotriacetic acid (NTA)
139-13-9 | 03/25/1977 | Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000,7500,15000 PPM/50 PER GROUP | Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
- Ureter: (ADENOMA OR PAPILLOMA)
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Tubular Cell: ADENOCARCINOMA
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Tubular Cell: ADENOCARCINOMA
|
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Nitrilotriacetic acid trisodium monohydrate
18662-53-8 | 03/25/1977 | Dosed-Feed
0,200,2000,20000 PPM/48 PER GROUP | SRI International |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Transitional Cell: CARCINOMA
- Kidney Tubular Cell: ADENOCARCINOMA OR CARCINOMA
- Ureter: (TRANSITIONAL CELL CARCINOMA)
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
- Ureter: (TRANSITIONAL CELL CARCINOMA)
- Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
|
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Nitrilotriacetic acid trisodium monohydrate
18662-53-8 | 03/25/1977 | Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000 PPM/50 PER GROUP | Litton Bionetics, Inc. |
Levels of Evidence
Male Rats: Equivocal
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Kidney Transitional Cell: PAPILLOMA
- Kidney Tubular Cell: ADENOCARCINOMA
|
Female Rats: Equivocal
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
|
Male Mice: Negative
Female Mice: Negative
