https://ntp.niehs.nih.gov/go/10937

Procarbazine hydrochloride: Target Organs and Levels of Evidence for TR-019

Bioassay of Procarbazine for Possible Carcinogenicity (CASRN 366-70-1)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Procarbazine hydrochloride
366-70-1
NA Intraperitoneal Injection
R: 0,15,30, M: 0,6,12 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Brain: (ADENOCARCINOMA, NEUROBLASTOMA, CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Brain: (NEUROBLASTOMA)
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Brain: (NEUROBLASTOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
  • Brain: (NEUROBLASTOMA)
  • Uterus/Cervix: (ADENOCARCINOMA)