Procarbazine hydrochloride: Target Organs and Levels of Evidence for TR-019
Bioassay of Procarbazine for Possible Carcinogenicity (CASRN 366-70-1)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Procarbazine hydrochloride
366-70-1 | NA | Intraperitoneal Injection
R: 0,15,30, M: 0,6,12 MG/KG/35 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
(LYMPHOMA OR LEUKEMIA)
- Mammary Gland:
(ADENOCARCINOMA)
- Brain:
(ADENOCARCINOMA, NEUROBLASTOMA, CARCINOMA)
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
(LYMPHOMA)
- Mammary Gland:
(ADENOCARCINOMA)
- Brain:
(NEUROBLASTOMA)
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
(LYMPHOMA OR LEUKEMIA)
- Brain:
(NEUROBLASTOMA)
- Lung:
(ALVEOLAR/BRONCHIOLAR ADENOMA)
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Hematopoietic System:
(LYMPHOMA OR LEUKEMIA)
- Lung:
(ALVEOLAR/BRONCHIOLAR ADENOMA)
- Brain:
(NEUROBLASTOMA)
- Uterus/Cervix:
(ADENOCARCINOMA)
|
