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Isophosphamide: Target Organs and Levels of Evidence for TR-032

Bioassay of Isophosphamide for Possible Carcinogenicity (CASRN 3778-73-2)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
09/26/1977Intraperitoneal Injection
R: 0,6,12, M: 0,10,20 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Uterus/Cervix: (LEIOMYOSARCOMA)
  • Mammary Gland: (FIBROADENOMA)
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA)