1,2-Dichloroethane: Target Organs and Levels of Evidence for TR-055
Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
1,2-Dichloroethane
107-06-2 | 03/06/1978 | Gavage
R: 0,47,95 (AVG), MM: 0,97,195 (AVG), FM: 0,149,299 (AVG) MG/KG/50 PER GROUP | Hazleton, Vienna |
Levels of Evidence
Male Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
(SQUAMOUS CELL CARCINOMA)
- Vascular System (Unspecified):
(HEMANGIOSARCOMA)
- Subcutaneous Tissue:
(FIBROMA)
|
Female Rats: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Mammary Gland:
(ADENOCARCINOMA)
|
Male Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
(ALVEOLAR/BRONCHIOLAR ADENOMA)
|
Female Mice: Positive
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Lung:
(ALVEOLAR/BRONCHIOLAR ADENOMA)
- Mammary Gland:
(ADENOCARCINOMA)
- Uterus/Cervix:
(POLYP, SARCOMA)
|
