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Estradiol mustard: Target Organs and Levels of Evidence for TR-059

Bioassay of Estradiol Mustard for Possible Carcinogenicity (CASRN 22966-79-6)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Estradiol mustard 22966-79-6	04/26/1978	Gavage R: 0,.62,1.25, M: 0,15,30 MG/KG/35 PER GROUP	Southern Research Institute

Levels of Evidence

Male Rats: Negative

Female Rats: Negative

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Hematopoietic System: (LYMPHOMA OR LEUKEMIA) Heart: (SARCOMA) Forestomach: (SQUAMOUS CELL CARCINOMA)

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Hematopoietic System: (LYMPHOMA) Heart: (SARCOMA) Forestomach: (SQUAMOUS CELL CARCINOMA)