https://ntp.niehs.nih.gov/go/10513

4-Chloro-o-phenylenediamine: Target Organs and Levels of Evidence for TR-063

Bioassay of 4-Chloro-o-phenylenediamine for Possible Carcinogenicity (CASRN 95-83-0)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
4-Chloro-o-phenylenediamine
95-83-0		 03/06/1978 Dosed-Feed
R: 0,.5,1.0 (AVG), M: 0,.7,1.4 (AVG) %DIET/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)