Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Aspirin, phenacetin, and caffeine: Target Organs and Levels of Evidence for TR-067

Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity (CASRN 8003-03-0)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
Aspirin, phenacetin, and caffeine
0,0.7,1.4 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: PAPILLOMA
  • Kidney Tubular Cell: ADENOCARCINOMA
Male Mice: Negative
Female Mice: Negative