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tris(2,3-Dibromopropyl) phosphate: Target Organs and Levels of Evidence for TR-076

Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CASRN 126-72-7)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
tris(2,3-Dibromopropyl) phosphate 126-72-7	03/06/1978	Dosed-Feed R: 0,50,100, M: 0,500,1000 PPM/55 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA, ADENOMA OR ADENOCARCINOMA

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA

Male Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA Forestomach: (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)

Female Mice: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL CARCINOMA) Liver: (ADENOMA, CARCINOMA) Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)