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https://ntp.niehs.nih.gov/go/8240

1,4-Dioxane: Target Organs and Levels of Evidence for TR-080

Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
1,4-Dioxane
123-91-1		03/07/1978Dosed-Water
0,0.5,1.0 %/70R - 100M PER GROUP		IIT Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: (SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA)
  • Nasal Cavity: (SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)