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Cupferron: Target Organs and Levels of Evidence for TR-100

Bioassay of Cupferron for Possible Carcinogenicity (CASRN 135-20-6)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Cupferron
135-20-6		06/29/1978Dosed-Feed
R: 0,.15,.30 M: 0,.2,.4 %/50 PER GROUP		T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
  • Liver: CARCINOMA
  • Forestomach: SQUAMOUS CELL CARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
  • Liver: CARCINOMA
  • Forestomach: SQUAMOUS CELL CARCINOMA
  • Zymbal Gland: CARCINOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Zymbal Gland: CARCINOMA
  • Vascular System (Unspecified): HEMANGIOMA OR HEMANGIOSARCOMA
  • Harderian Gland: ADENOMA