https://ntp.niehs.nih.gov/go/13431

5-Nitro-o-anisidine: Target Organs and Levels of Evidence for TR-127

Bioassay of 5-Nitro-o-anisidine for Possible Carcinogenicity (CASRN 99-59-2)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
5-Nitro-o-anisidine
99-59-2		 06/29/1978 Dosed-Feed
R: 0,.4,.8, M: 0,.4,.8,1.6 %/50 PER GROUP		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA)
  • Zymbal Gland: (CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: (ADENOMA, CARCINOMA)
  • Zymbal Gland: (CARCINOMA)
Male Mice: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)