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3,3'-Dimethoxybenzidine-4,4'-diisocyanate: Target Organs and Levels of Evidence for TR-128

Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CASRN 91-93-0)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
3,3'-Dimethoxybenzidine-4,4'-diisocyanate 91-93-0	08/31/1978	Dosed-Feed 0,22000,44000 PPM/50 PER GROUP	Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Skin: (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA) Hematopoietic System: (LYMPHOMA OR LEUKEMIA) Zymbal Gland: (CARCINOMA)

Female Rats: Positive

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Hematopoietic System: (LYMPHOMA OR LEUKEMIA) Uterus/Cervix: (POLYP) Zymbal Gland: (CARCINOMA)

3,3'-Dimethoxybenzidine-4,4'-diisocyanate: Target Organs and Levels of Evidence for TR-128

Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CASRN 91-93-0)

Levels of Evidence

Male Rats: Positive

Female Rats: Positive

Male Mice: Negative

Female Mice: Negative