https://ntp.niehs.nih.gov/go/7114

Pivalolactone: Target Organs and Levels of Evidence for TR-140

Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Pivalolactone
1955-45-9
06/29/1978 Gavage
R: 0,150,300, M: 0,75,150 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR CARCINOMA)
Male Mice: Negative
Female Mice: Negative